Results 81 to 90 of about 6,619,911 (229)

Increased renal integrin αvβ3 expression in anti-GBM disease.

, 2013
(a–c) IHC staining of mouse kidney sections with an anti-integrin αvβ3 antibody (1:500 dilution). (a) Normal control kidney; (b) nephritic kidney subjected to anti-GBM disease; (c) Semi-quantitative analysis of integrin αvβ3 expression (N = 6 for each ...
Xin J. Zhou (305431), Shion An (305429), Chandra Mohan (157054), Li Liu (75607), Yong Du (86188), Ralph P. Mason (131100), Li Li (14993)   +6 more
core   +1 more source

Retransplantation in Alport post-transplant anti-GBM disease [PDF]

, 2004
Post transplant anti-glomerular basement membrane (GBM) disease affects up to 5% of patients with Alport's syndrome. Defects in the COL4A5 gene are responsible for most cases, and alpha 5(IV)NC1 is the usual target for alloantibodies.
Rees, Andrew J., Tomson, Charles R V, Herriot, Richard, Brown, Paul A J, Brown, Paul A.J., Turner, A. Neil, Browne, Gemma, Pusey, Charles D., Fleming, Stewart, Rees, Andrew J, Allen, Andrew, Turner, A Neil, Pusey, Charles D, Tomson, Charles R.V.   +13 more
core   +1 more source

Magneto‐NIR‐II‐Programmed Cascade Nanozymes Unlocking Blood–Brain Barrier Translocation and Autophagic Resistance in Glioblastoma

Advanced Science, EarlyView.
Magneto‐NIR‐II‐programmed NFSH nanozymes integrate magnetic blood–brain barrier (BBB) translocation, CD44 targeting, multimodal imaging, and cascade catalytic therapy for glioblastoma. Alternating magnetic fields and NIR‐II irradiation amplify ferroptosis, release H2S, suppress autophagic and mitophagic repair, and reshape the immune microenvironment ...
Ruocan Liu, Yundi Wu, Shuai Zhang, Hongjuan Zhao, Jiping Zheng, Shiyang Shao, Jianqiang Chen, Xilong Wu   +7 more
wiley   +1 more source

TAB2 Causes Neuronal Damage by Aggravating Microglia‐Mediated Neuroinflammation in Parkinson's Disease

Advanced Science, EarlyView.
In microglia, STAT3 upregulates TAB2, which promotes NF‐κB activation through its NZF domain‐mediated recognition of K63‐linked ubiquitin chains, leading to inflammatory cytokine release and subsequent neuronal injury. Lumacaftor suppresses TAB2 expression and directly binds the TAB2‐NZF domain to interrupt K63 ubiquitin recognition, thereby blocking ...
Yanhao Zhao, Zimeng Huang, Jianing Gao, Aolan Li, Huizhi Wang, Yingchuan Chen, Guanyu Zhu, Xin Zhang, Yin Jiang, Moxuan Zhang, Fangang Meng, Jianguo Zhang, Tingting Du   +12 more
wiley   +1 more source

Complement in anti-glomerular basement membrane glomerulonephritis

Frontiers in Immunology
Anti-glomerular basement membrane glomerulonephritis (anti-GBM GN) is a rare autoimmune disease that often progresses to end-stage renal disease (ESRD).
Pei Zhang, Kai-li Shi, Chun-lin Gao, Feng Xu, Li-li Jia, Ji-chao Sun   +5 more
doaj   +1 more source

GBM-specific significant network.

, 2019
(A) The SM pairs and interconnecting paths between them that have a significant impact on EGFR-mediated GBM were filtered from the GBM-specific network using the mathematical model of Fig 5 and combined to generate the final signaling-metabolic ...
Arup K. Bag (7140053), Chitra Mandal (148111), Peter Walden (58355), Saikat Chakrabarti (5065), Chhabinath Mandal (194022), Sapan Mandloi (2805019), Saulius Jarmalavicius (194019), Susmita Mondal (174649), Krishna Kumar (385545)   +8 more
core   +1 more source

Renal antigens in mercuric chloride induced, anti-GBM autoantibody glomerular disease [PDF]

, 1990
Renal antigens in mercuric chloride induced, anti-GBM autoantibody glomerular disease. Two antibody probes were used to characterize the putative renal antigens of HgCl2-induced antiglomerular basement membrane renal disease in Brown Norway (BN) rat. The
Kanalas, John J., Makker, Sudesh P.
core   +1 more source

SPARC Drives Podocyte Mitochondrial Damage and Ferroptosis in Diabetic Kidney Disease Following Klotho Deficiency

Advanced Science, EarlyView.
Klotho deficiency promotes podocyte mitochondrial dysfunction and ferroptosis through activation of the PKCα/CUX1/SPARC/TGFβ‐RII axis. SPARC emerges as a key mediator linking Klotho loss to podocyte injury in DKD and other kidney injury models, suggesting broader implications for CKD progression.
Qing Yang, Huimin Jiang, Chenyang Xiong, Xindi Zhou, Qinqin Tan, Han Xiao, Lan Qiu, Chun Gan, Yaxi Chen, Haiping Yang, Wei Jiang, Qiu Li   +11 more
wiley   +1 more source

ruoyusun/GBM-Hg-ISO-EPME: GBM-Hg-ISO-EPME

, 2023
We develop a global box model of Hg isotopes (GBM-Hg-ISO-EPME) to investigate the mechanism of Hg enrichment and Hg isotopic variations across the EPME. Full Changelog: https://github.com/ruoyusun/GBM-Hg-ISO-EPME/commits/v1.
Ruoyu SUN
core   +1 more source

Lactate‐Induced K370 Lactylation of STING Inhibits STING‐TBK1 Signaling and Dampens Anti‐Tumor Immunity

Advanced Science, EarlyView.
Lactate accumulation in glioblastoma drives lactylation of STING at lysine 370, a primate‐conserved residue. K370 lactylation weakens STING‐TBK1 binding, destabilizes STING, and disrupts ER‐to‐Golgi trafficking, blunting type I interferon signaling. LDHA inhibition reverses K370 lactylation and improves the antitumor efficacy of STING agonism combined ...
Yueyao Wu, Jingzhe Wang, Xu Chen, Yuntong Yang, Ping Wei, Han Xie, Honghao Wang, Chunyu Zhang, Siyi Xu, Qi Wang, Chunlong Zhong, Jing Zhang   +11 more
wiley   +1 more source