Results 61 to 70 of about 6,619,911 (229)

Anti-GBM disease and ANCA during dengue infection

, 2015
Anti-glomerular basement membrane (GBM) disease is a severe inflammatory renal disorder due to pathogenic autoantibodies directed mainly against the α3 chain of type IV collagen.
Contreras, Gabriel N, Lizarraga, Karlo J, Nayer, Ali, Daftarian, Pirouz, Andrews, David M, Ortega, Luis M, Mendoza, Jair Munoz, Florindez, Jorge A   +7 more
core   +1 more source

Engineered Microvascular Model of the Blood–Brain–Tumor Barrier Reveals Endothelial Remodeling in Diffuse Midline Glioma

Advanced Healthcare Materials, EarlyView.
We developed a patient‐derived, functional microfluidic model of the diffuse midline glioma (DMG) blood–brain–tumor barrier (BBTB) comprised of endothelial cells, astrocytes, pericytes, and tumor cells. The system forms perfusable microvasculature, reveals the BBTB retains vascular integrity, identifies DMG‐specific transcriptomic changes distinct from
Kimberly R. Bennett, Yann S. Vanrobaeys, Tessy Teboh, Zakiya Smith, Anderson Scott, Cynthia Hajal, Paula T. Hammond, Joelle P. Straehla   +7 more
wiley   +1 more source

From Cell‐Derived Vesicles to Hybrid Nanovectors: Biological Membranes as Functional Blueprints for Gene Delivery

Advanced Healthcare Materials, EarlyView.
Biologically derived and hybrid nonviral nanovectors are examined as distinct but convergent design approaches. Integrating synthetic components with biologically functionalized membranes allows efficient interactions with complex cellular environments.
Clara Baldari, Claudia Leone, Gabriella Leccese, Claudia De Stradis, Alessandra Invidia, Concetta Quintarelli, Biagio De Angelis, Franco Locatelli, Giuseppe Gigli, Gabriele Maiorano, Ilaria Elena Palamà   +10 more
wiley   +1 more source

IgA Vasculitis and Anti-GBM disease: two ends of a spectrum of immune complex vasculitis [PDF]

, 2020
Two immune complex vasculitides, IgA vasculitis (IgAV) and anti-GBM disease, represent polar extremes with regard to our understanding of disease pathogenesis, standardized management protocols and outcomes.
Salama, A
core   +1 more source

Advanced Materials for Biologics Delivery to Brain Tumors

Advanced Materials, EarlyView.
Material innovation is central to unlocking the therapeutic potential of biologics against many central nervous system diseases, including brain cancer. By engineering carriers with controlled transport, targeting, and release properties, advanced materials can overcome the blood–brain barrier and tumor microenvironment, improving the delivery of ...
Yuran Feng, Yuxue Cao, Maria Kavallaris, Taskeen Janjua, Amirali Popat   +4 more
wiley   +1 more source

Renal-Limited Antiglomerular Basement Membrane Disease Related To Alemtuzumab: A Case Report

Canadian Journal of Kidney Health and Disease, 2020
Rationale: Alemtuzumab is a monoclonal antibody approved for the treatment of relapsing-remitting multiple sclerosis (RRMS). Many autoimmune-mediated adverse events have been associated with alemtuzumab, including renal-limited anti-glomerular basement ...
Amye M. Harrigan, Michael L. West, Laurette Geldenhuys, Penelope Poyah   +3 more
doaj   +1 more source

LF15-0195 prevents the induction and inhibits the progression of rat anti-GBM disease [PDF]

, 2001
LF15-0195 prevents the induction and inhibits the progression of rat anti-GBM disease.BackgroundLF15-0195 is a novel immunosuppressant that is currently in phase II clinical trials for the treatment of vasculitis.
Wei, Mu, Hill, Prudence A., Tesch, Gregory H., Dutartre, Patrick, Atkins, Robert C., Nikolic-Paterson, David J.   +5 more
core   +1 more source

32. Age and time-dependent increase in incident anti-glomerular basement membrane (anti-GBM) disease-a nation-wide cohort study

, 2022
Background: Anti-GBM disease is a rare type of severe small vessel vasculitis that can lead to pulmonary haemorrhage and kidney failure. Epidemiologic studies of unselected patients have been challenged due to the low disease incidence and non-relapsing ...
Szpirt, Wladimir, Egfjord, Martin, Rigshospitalet, Copenhagen University Hospital, Carlsson, Nicholas, The Faculty of Medicine, Nelveg-Kristensen, Karl Emil, Department of Clinical Medicine, McClure, Mark, Torp-Pedersen, Christian, University of Cambridge   +9 more
core   +1 more source

TET1 Inhibition Promotes Therapeutic Sensitivity in TP53‐Mutant GBM by Influencing Genome Fragility and Altering TAMs Biology

Advanced Science, EarlyView.
In TP53mut GBM cells, reduced P53 function is associated with increased TET1 expression. Genetic or pharmacological inhibition of TET1 correlates with genome fragility, including DNA damage, cellular senescence, telomere shortening, and reactive oxygen species accumulation, which may contribute to increased efficacy of antitumor therapy.
Zhuonan Pu, Jinqiu Liu, Yuxuan Deng, Shuyu Hao, Xiaoli Zhang, Mingxu Yang, Chao Guo, Chao Du, Yingdan Chen, Tai Sun, Nan Ji, Zhengping Zhuang, Jie Feng   +12 more
wiley   +1 more source

Anti-glomerular Basement Membrane Disease: A Rare Case Report of Changing Clinical Phenotype and Atypicalities

Saudi Journal of Kidney Diseases and Transplantation, 2021
A man in his late 20s, a smoker, presented with nephrotic-range proteinuria and mild renal failure. He had no macroscopic hematuria or decreased urine output.
Kaaviya Ramesh, Balasubramanian Thoppalan, R Venkatraman, Sugan Gandhi   +3 more
doaj   +1 more source