Results 201 to 210 of about 65,156 (262)
Serum Levels and Genetic Variants of CC16: Associations With Asthma and Lung Function Development
Clinical &Experimental Allergy, EarlyView.
Hans Jacob L. Koefoed +7 more
wiley +1 more source
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Immunology and Allergy Clinics of North America, 2004
IgE has a central role in the initiation of allergic hypersensitivity reactions. Pioneered by the development of humanized monoclonal antibodies directed against IgE, anti-IgE therapy represents an original approach to the treatment of allergic disease and has demonstrated promise in preventing the symptoms of asthma, allergic rhinitis, and food ...
Jaine, Brownell, Thomas B, Casale
openaire +2 more sources
IgE has a central role in the initiation of allergic hypersensitivity reactions. Pioneered by the development of humanized monoclonal antibodies directed against IgE, anti-IgE therapy represents an original approach to the treatment of allergic disease and has demonstrated promise in preventing the symptoms of asthma, allergic rhinitis, and food ...
Jaine, Brownell, Thomas B, Casale
openaire +2 more sources
2023
From the published studies of E25, it is now clear that this approach to treating atopic disease can be successful. But there remain many issues, both practical and biological. For the study of atopic disease, a potentially excellent new tool has been provided that could allow IgE to be effectively eliminated, given the correct-dosing regimen, and ...
openaire +2 more sources
From the published studies of E25, it is now clear that this approach to treating atopic disease can be successful. But there remain many issues, both practical and biological. For the study of atopic disease, a potentially excellent new tool has been provided that could allow IgE to be effectively eliminated, given the correct-dosing regimen, and ...
openaire +2 more sources
Current Opinion in Immunology, 1995
Controlling the IgE response at either the synthesis level or the effector phase should have a profound impact on the allergic cascade. For more than a decade, researchers have focused on ways of interfering with the binding of IgE to its high-affinity receptor on proinflammatory cells.
openaire +2 more sources
Controlling the IgE response at either the synthesis level or the effector phase should have a profound impact on the allergic cascade. For more than a decade, researchers have focused on ways of interfering with the binding of IgE to its high-affinity receptor on proinflammatory cells.
openaire +2 more sources
Anti‐IgE in allergic sensitization
Immunology & Cell Biology, 1996SummaryAnti‐IgE autoantibodies exist predominantly in the sera of patients with atopic disease. For some time such anti‐IgE autoantibodies have been considered a phenomenon that may not be of clinical importance. The cloning of such anti‐IgE autoantibodies has eliminated doubts of whether these antibodies exist, but it is still unclear whether such ...
B M, Stadler +4 more
openaire +2 more sources
Anti-IgE – emerging opportunities for Omalizumab
Expert Opinion on Biological Therapy, 2013Omalizumab is a recombinant DNA-derived humanized IgG1 monoclonal antibody that selectively binds to free and membrane-bound immunoglobulin E (IgE) antibodies. Omalizumab has been licensed for use in severe allergic asthma. A search on the website clinicaltrials.gov reveals there are currently 109 clinical trials with Omalizumab of which 46 are for ...
Babu K. Suresh +2 more
openaire +2 more sources
2016
The propensity to develop an exaggerated antibody response to inhaled antigens operated by immunoglobulin E (IgE), which is defined as atopy, plays a central role in the pathobiology of allergic asthma [1]. The pleiotropic effects of IgE are mediated by activation of specific IgE receptors expressed by both immune-inflammatory and airway structural ...
Pelaia, Girolamo +2 more
openaire +1 more source
The propensity to develop an exaggerated antibody response to inhaled antigens operated by immunoglobulin E (IgE), which is defined as atopy, plays a central role in the pathobiology of allergic asthma [1]. The pleiotropic effects of IgE are mediated by activation of specific IgE receptors expressed by both immune-inflammatory and airway structural ...
Pelaia, Girolamo +2 more
openaire +1 more source
Annali di igiene : medicina preventiva e di comunita, 1989
The production of the five classes of immunoglobulins represents the highest grade of the various system of defence the man puts in act against the microbial attack. So bacteria fight in several levels across the different stages of human antibodies synthesis processes and action, trying for cancelling the effect.
DEL PIANO, Massimo +4 more
openaire +2 more sources
The production of the five classes of immunoglobulins represents the highest grade of the various system of defence the man puts in act against the microbial attack. So bacteria fight in several levels across the different stages of human antibodies synthesis processes and action, trying for cancelling the effect.
DEL PIANO, Massimo +4 more
openaire +2 more sources
2002
Omalizumab is a recombinant humanised monoclonal antibody directed against immunoglobulin E (IgE) to inhibit the immune system's response to allergen exposure. Omalizumab is directed against the binding site of IgE for its high affinity Fc receptor.
S, Walker +4 more
openaire +2 more sources
Omalizumab is a recombinant humanised monoclonal antibody directed against immunoglobulin E (IgE) to inhibit the immune system's response to allergen exposure. Omalizumab is directed against the binding site of IgE for its high affinity Fc receptor.
S, Walker +4 more
openaire +2 more sources
Combining anti‐IgE with oral immunotherapy
Pediatric Allergy and Immunology, 2017AbstractFood allergy is a significant medical problem that affects up to 8% of children in developed countries. At present, there are no curative therapies available in routine practice and management of food allergy involves strict allergen avoidance, education, and prompt treatment upon accidental exposure.
Chunrong Lin +6 more
openaire +4 more sources