Results 51 to 60 of about 9,467,496 (262)

Applicability of Escherichia coli As an Indicator for Assessing Quality of Disinfectants and Antiseptic During the COVID-19 Pandemic

Journal of Environmental Health and Sustainable Development, 2021
Introduction: The application of disinfectant agents is a common way to fight against microorganisms. Although there are different types of disinfectant agents to fight COVID-19, many of them do not have the required quality and efficiency.
Reza Ali Fallahzadeh, Fariborz Omidi, Davoud Ghadirian, Azimeh Fallahzadeh, Mohammad Reza Nafisi   +4 more
doaj  

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Anti-infective ophthalmic preparations in general practice [PDF]

, 2012
CITATION: Smit, D. 2012. Anti-infective ophthalmic preparations in general practice. South African Family Practice, 54(4):302-307.The original publication is available at http://www.safpj.co.zaOcular infections may be bacterial, viral, fungal or ...
D Smit, D. Smit, Smit, Derrick
core   +1 more source

A PERSPECTIVE ON ANTIINFECTIVE AGENTS INTERACTION IN HUMAN IMMUNODEFICIENCY VIRUS PATIENTS WITH MALARIAL INFECTION [PDF]

, 2016
Despite recent research advances in anti-infective agents (achievements), Human immunodeficiency virus (HIV), and malaria infection are currentlyconsidered two main global human health problems. Given the considerable geographical overlap between malaria
Bhopale, Girish M
core   +1 more source

Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy

Molecular Oncology, EarlyView.
LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir, Elena Haro‐Martínez, Sandra Blasco‐Benito, Chiara Cannatà, José Ángel Palomeque, Anna López‐Plana, Maria Sanz‐Flores, Marc Sabartés, Cristina Fornaguera, Toni Celià‐Terrassa   +9 more
wiley   +1 more source

Can a New Antiseptic Agent Reduce the Bacterial Colonization Rate of Central Venous Lines in Post- Cardiac Surgery Patients?

Journal of Tehran University Heart Center, 2015
Background: Central venous (CV) catheters play an essential role in the management of critically ill patients in the Intensive Care Unit (ICU). CV lines are, however, allied to catheter-associated blood stream infections.
Fardin Yousefshahi, Khashayar Azimpour, MohammadAli Boroumand, Mahdi Najafi, Khosro Barkhordari, Mitra Vaezi, Nahid Rouhipour   +6 more
doaj  

Microbiological evaluation of different antiseptic povidone-iodine and chlorhexidine formulations after intentional contamination of containers Evaluación microbiológica de las diferentes formulaciones antisépticas, polivinil-pirrolidona-yodo y clorexidina, después de la contaminación intencional de los recipientes Avaliação microbiológica das diferentes formulações anti-sépticas, polivinilpirrolidona-iodo e clorexidina, após contaminação intencional das almotolias

Revista Latino-Americana de Enfermagem, 2008
This study aimed to evaluate the survival rate of microorganisms within different antiseptic formulations - povidone-iodine (PVP-I) and chlorhexidine (CHX) - after intentional contamination, and to establish the minimum care necessary to ensure ...
Christiane Moreira Padovani, Kazuko Uchikawa Graziano, Vânia Regina Goveia   +2 more
doaj   +1 more source

Dactolisib outperforms Rapamycin in potentiating apoptosis induced by XPO1, Bcl‐2 and Mcl‐1 blockade in preclinical glioblastoma models

FEBS Open Bio, EarlyView.
The PAM pathway and its impact on cellular metabolism. Color‐coded key symbols represent Rapamycin (R, orange, targeting mTOR) and Dactolisib (D, green, targeting PI3K/mTOR), indicating their sites of action. Created with BioRenders.com. Glioblastoma resists therapy through interconnected survival programs.
Kai Zhao, Leonie Meyer, Madita Braun, Katharina Otte, Celine Bitter, Maite Pawlik, Hartmann Raifer, Frederik Helmprobst, Axel Pagenstecher, Hans Urban, Michael C. Burger, Michael W. Ronellenfitsch, Joachim P. Steinbach, Jarmila Jedelská, Shamim Bagheri, Behrooz H. Yousefi, Pietro Di Fazio, Markus Luster, Andreas H. Mahnken, Andreas Neubauer, Andreas Burchert, Christopher Nimsky, Jörg W. Bartsch, Tillmann Rusch   +23 more
wiley   +1 more source

Secretory Profile of Selected Gut Bacteria of Cockroaches: A Potential Source of Anti-Infective Agents

, 2022
Pests, such as cockroaches, thrive in polluted conditions that are detrimental to Homo sapiens, suggesting that such species possess mechanisms to protect themselves against pathogens.
Ruqaiyyah Siddiqui, Akbar, Noor, Naveed Ahmed Khan, Mohamed Yehia Abouleish, Abouleish, Mohamed Yehia, Jibran Sualeh Muhammad, Siddiqui, Ruqaiyyah, Muhammad, Jibran Sualeh; id_orcid, Khan, Naveed Ahmed, Muhammad, Jibran Sualeh, Noor Akbar, Khan, Naveed Ahmed *   +11 more
core   +1 more source

Long‐Term Efficacy of Immunotherapy in Autoimmune Autonomic Ganglionopathy—A 10‐Year Follow Up Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Autoimmune autonomic ganglionopathy (AAG) is a rare but potentially treatable cause of severe autonomic failure. Evidence guiding long‐term immunotherapy, treatment sequencing, and residual autonomic impairment is limited. We evaluated long‐term treatment response, residual autonomic dysfunction, and relapse patterns in patients with
Giacomo Chiaro, Shiwen Koay, Gordon T. Ingle, Patricia McNamara, Laura Watson, Fion Bremner, Valeria Iodice   +6 more
wiley   +1 more source