Results 281 to 290 of about 112,322 (317)
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Anti-infective agents and hepatic disease
Medical Clinics of North America, 1995Numerous factors such as changes in plasma protein binding, tissue binding, hepatic blood flow, hepatic metabolism, and distribution may occur in hepatic disease. The impact of these physiologic changes on pharmacokinetic and pharmacodynamic parameters of anti-infective agents is likely to be clinically significant. Unfortunately, these issues have not
Kyle Vance-Bryan +2 more
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Benzothiazole Derivatives as Potential Anti-Infective Agents
Current Topics in Medicinal Chemistry, 2016Severity of microbial infections and escalating resistance towards antibiotics has created a deep necessity for discovery of novel anti-infective agents. Heterocyclic chemistry of benzothiazole has become one of the most prolific areas in the field of drug discovery and development that has attracted great attention in recent time due to its increasing
Sharma, Prabodh Chander +3 more
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Ferrocene derivatives as anti-infective agents
Coordination Chemistry Reviews, 2019Abstract Infectious diseases like malaria, tuberculosis or HIV are among the leading causes of death worldwide according to WHO estimations. Nevertheless, the fight against infectious diseases is aggravated through growing development of resistance towards current drugs and due to their severe adverse effects.
Fritz E. Kühn +2 more
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Inhaled Anti-infective Agents: Emphasis on Colistin
Infection, 2010The administration of antibiotics by the inhaled route is a widely recognized treatment in patients with cystic fibrosis (CF) and bronchiectasis. Tobramycin solution for inhalation (TOBI) has been available for many years and is licensed in the USA and Europe. While strong data support the use of aerosolized antibiotics for the treatment of respiratory
A. Michalopoulos, E. Papadakis
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Vitamin D: a new anti‐infective agent?
Annals of the New York Academy of Sciences, 2014Before the antibiotic era, treatment of tuberculosis patients was restricted to sun exposure in sanatoria. Years later, it was found that 1,25‐dihydroxyvitamin D3 stimulates production of cathelicidins, a family of polypeptides found in lysosomes of macrophages and polymorphonuclear leukocytes.
Eitan Israeli +5 more
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1984
In the 50-year period since Fleming made his monumental discovery of penicillin, a vast array of anti-infective agents have been developed to combat the plethora of infectious microorganisms plaguing mankind. While once the ophthalmologist had only penicillin to resort to when faced with ocular infection, his choice now includes myriads of antibiotics.
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In the 50-year period since Fleming made his monumental discovery of penicillin, a vast array of anti-infective agents have been developed to combat the plethora of infectious microorganisms plaguing mankind. While once the ophthalmologist had only penicillin to resort to when faced with ocular infection, his choice now includes myriads of antibiotics.
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Trends in development of anti‐infective agents in Japan
Pediatrics International, 1997AbstractNewly developed anti‐infective agents have been continuously supplied in the clinics of Japan over the past 50 years, and were beneficial in saving patients from life‐threatening infections. However, the emergence of resistant bacteria and uncommon pathogens has caused complications in chemotherapy.
Keisuke Sunakawa, Morimasa Yagisawa
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1995
Chemotherapeutic agents are intended to eliminate foreign organisms or abnormal cells from healthy tissues of the patient. An essential property of all chemotherapeutic drugs is selective toxicity; deleterious actions directed against the target cells without comparable effects on the tissue of the host.
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Chemotherapeutic agents are intended to eliminate foreign organisms or abnormal cells from healthy tissues of the patient. An essential property of all chemotherapeutic drugs is selective toxicity; deleterious actions directed against the target cells without comparable effects on the tissue of the host.
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Pharmacokinetic/ pharmacodynamic evaluation of anti-infective agents
Expert Review of Anti-infective Therapy, 2005Pharmacokinetic/pharmacodynamic modeling has become an extremely important tool in evaluating and optimizing anti-infective therapy. By systematically linking the pharmacokinetic and pharmacodynamic properties of the anti-infective agent, it is possible to make educated decisions about the correct drug to be used, correct dosing regimen and to estimate
Hartmut Derendorf, Edgar L. Schuck
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Minor groove binders as anti-infective agents
Pharmacology & Therapeutics, 2013Minor groove binders are small molecules that form strong complexes with the minor groove of DNA. There are several structural types of which distamycin and netropsin analogues, oligoamides built from heterocyclic and aromatic amino acids, and bis-amidines separated by aromatic and heterocyclic rings are of particular pharmaceutical interest.
Barrett, M.P. +2 more
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