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Cheminformatics in Anti-Infective Agents Discovery
Mini-Reviews in Medicinal Chemistry, 2007The existing chemical data such as those created by high throughput screening (HTS), structure-activity relationship (SAR) studies are converted into information as a result of storage and registration. Accessibility, manipulation, and data mining of such information make up the knowledge for drug development.
Mohammad Haj Dezfulian, Soroush Sardari
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Pharmacogenomics of Anti-Infective Agents
2020Ever since we know that the dissimilarities of medications are influenced by the in vivo process of the body, including absorption, distribution, metabolization, and excretion, great attentions have been paid on pharmacogenomic issues, trying to figure out the underlying mechanisms of drug response deviations.
Qian Zhang, Xianmin Meng, Ping Dong
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Anti-infective agents and hepatic disease
Medical Clinics of North America, 1995Numerous factors such as changes in plasma protein binding, tissue binding, hepatic blood flow, hepatic metabolism, and distribution may occur in hepatic disease. The impact of these physiologic changes on pharmacokinetic and pharmacodynamic parameters of anti-infective agents is likely to be clinically significant. Unfortunately, these issues have not
Kyle Vance-Bryan +2 more
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Benzothiazole Derivatives as Potential Anti-Infective Agents
Current Topics in Medicinal Chemistry, 2016Severity of microbial infections and escalating resistance towards antibiotics has created a deep necessity for discovery of novel anti-infective agents. Heterocyclic chemistry of benzothiazole has become one of the most prolific areas in the field of drug discovery and development that has attracted great attention in recent time due to its increasing
Sharma, Prabodh Chander +3 more
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Ferrocene derivatives as anti-infective agents
Coordination Chemistry Reviews, 2019Abstract Infectious diseases like malaria, tuberculosis or HIV are among the leading causes of death worldwide according to WHO estimations. Nevertheless, the fight against infectious diseases is aggravated through growing development of resistance towards current drugs and due to their severe adverse effects.
Fritz E. Kühn +2 more
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Inhaled Anti-infective Agents: Emphasis on Colistin
Infection, 2010The administration of antibiotics by the inhaled route is a widely recognized treatment in patients with cystic fibrosis (CF) and bronchiectasis. Tobramycin solution for inhalation (TOBI) has been available for many years and is licensed in the USA and Europe. While strong data support the use of aerosolized antibiotics for the treatment of respiratory
A. Michalopoulos, E. Papadakis
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Trends in development of anti‐infective agents in Japan
Pediatrics International, 1997AbstractNewly developed anti‐infective agents have been continuously supplied in the clinics of Japan over the past 50 years, and were beneficial in saving patients from life‐threatening infections. However, the emergence of resistant bacteria and uncommon pathogens has caused complications in chemotherapy.
Keisuke Sunakawa, Morimasa Yagisawa
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Vitamin D: a new anti‐infective agent?
Annals of the New York Academy of Sciences, 2014Before the antibiotic era, treatment of tuberculosis patients was restricted to sun exposure in sanatoria. Years later, it was found that 1,25‐dihydroxyvitamin D3 stimulates production of cathelicidins, a family of polypeptides found in lysosomes of macrophages and polymorphonuclear leukocytes.
Eitan Israeli +5 more
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