Results 291 to 300 of about 119,511 (340)
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1984
In the 50-year period since Fleming made his monumental discovery of penicillin, a vast array of anti-infective agents have been developed to combat the plethora of infectious microorganisms plaguing mankind. While once the ophthalmologist had only penicillin to resort to when faced with ocular infection, his choice now includes myriads of antibiotics.
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In the 50-year period since Fleming made his monumental discovery of penicillin, a vast array of anti-infective agents have been developed to combat the plethora of infectious microorganisms plaguing mankind. While once the ophthalmologist had only penicillin to resort to when faced with ocular infection, his choice now includes myriads of antibiotics.
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1995
Chemotherapeutic agents are intended to eliminate foreign organisms or abnormal cells from healthy tissues of the patient. An essential property of all chemotherapeutic drugs is selective toxicity; deleterious actions directed against the target cells without comparable effects on the tissue of the host.
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Chemotherapeutic agents are intended to eliminate foreign organisms or abnormal cells from healthy tissues of the patient. An essential property of all chemotherapeutic drugs is selective toxicity; deleterious actions directed against the target cells without comparable effects on the tissue of the host.
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Pharmacokinetic/ pharmacodynamic evaluation of anti-infective agents
Expert Review of Anti-infective Therapy, 2005Pharmacokinetic/pharmacodynamic modeling has become an extremely important tool in evaluating and optimizing anti-infective therapy. By systematically linking the pharmacokinetic and pharmacodynamic properties of the anti-infective agent, it is possible to make educated decisions about the correct drug to be used, correct dosing regimen and to estimate
Hartmut Derendorf, Edgar L. Schuck
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Antimicrobial peptides: Possible anti-infective agents
Peptides, 2015Multidrug-resistant bacterial, fungal, viral, and parasitic infections are major health threats. The Infectious Diseases Society of America has expressed concern on the decrease of pharmaceutical companies working on antibiotic research and development.
Jayaram Lakshmaiah Narayana +2 more
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Minor groove binders as anti-infective agents
Pharmacology & Therapeutics, 2013Minor groove binders are small molecules that form strong complexes with the minor groove of DNA. There are several structural types of which distamycin and netropsin analogues, oligoamides built from heterocyclic and aromatic amino acids, and bis-amidines separated by aromatic and heterocyclic rings are of particular pharmaceutical interest.
Barrett, M.P. +2 more
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Clinical Use of Anti-infective Agents
2012clinical use of anti-infective agents , clinical use of anti-infective agents , کتابخانه دیجیتالی دانشگاه علوم پزشکی و خدمات درمانی شهید ...
Roy Guharoy, Robert W. Finberg
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Pharmacokinetics of Anti-Infective Agents in Paediatric Patients
Clinical Pharmacokinetics, 1994Various differences in drug disposition exist between children and adults. For example, the volume of distribution (Vd) for many drugs is larger in children than in adults. Other parameters, including excretion and elimination may be altered in children compared with adults.
Mary H. H. Chandler +2 more
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Hyperbaric oxygen therapy as an anti-infective agent
Expert Review of Anti-infective Therapy, 2009Hyperbaric oxygen therapy (HBOT) involves inhalation of 100% oxygen at supra-atmospheric ambient pressure. HBOT is used as either a primary or adjunctive treatment in the management of infections such as gas gangrene, necrotizing fasciitis, diabetic foot infections, refractory osteomyelitis, neurosurgical infections and fungal infections.
Guenalp Uzun, Senol Yildiz, Maide Cimsit
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Defensins as anti-infective and immunomodulatory agents
Expert Opinion on Therapeutic Patents, 2006Defensins are a large family of polypeptides occuring in most animals and plants. Since the first description of a defensin in 1985, the members of this peptide class are considered to play an important role in the innate immune defence of organisms, protecting against invading pathogens by killing bacteria and other microbes.
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Antibody-based therapies as anti-infective agents
Expert Opinion on Investigational Drugs, 1998Antibody-based therapies are effective against a wide variety of pathogens. Historically, antibody-based therapies were largely abandoned with the advent of antimicrobial chemotherapy, due to the toxicity associated with the administration of heterologous immune sera.
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