Results 191 to 200 of about 5,527,968 (391)

Soman induces endoplasmic reticulum stress and apoptosis of cerebral organoids via the GRP78‐ATF6‐CHOP signaling pathway

FEBS Open Bio, EarlyView.
Cerebral organoids were employed as a novel model to explore the neurotoxicity of soman. Soman inhibited acetylcholinesterase activity, increased cell apoptosis and upregulated endoplasmic reticulum (ER) stress markers glucose‐regulated protein 78 (GRP78), activating transcription factor 6 (ATF6) and C/EBP homologous protein (CHOP).
Yue Wei, Zhanbiao Liu, Jingjing Shi, Qian Jin, Wenqian Chen, Xuejun Chen, Liqin Li, Hui Chen   +7 more
wiley   +1 more source

Lianhuaqingwen exerts anti-viral and anti-inflammatory activity against novel coronavirus (SARS-CoV-2)

Pharmacological Research, 2020
Run-feng Li, Yunlong Hou, Jicheng Huang, Pan Weiqi, Qinhai Ma, Yongxia Shi, Chufang Li, Zhao Jin, Z. Jia, Haiming Jiang, Zheng Kui, Shuxiang Huang, Dai Jun, Xiaobo Li, Xiaotao Hou, Wang Lin, Nanshan Zhong, Zi-feng Yang   +17 more
semanticscholar   +1 more source

Long non‐coding RNAs as therapeutic targets in head and neck squamous cell carcinoma and clinical application

FEBS Open Bio, EarlyView.
Long non‐coding RNAs (lncRNAs) occupy an abundant fraction of the eukaryotic transcriptome and an emerging area in cancer research. Regulation by lncRNAs is based on their subcellular localization in HNSCC. This cartoon shows the various functions of lncRNAs in HNSCC discussed in this review.
Ellen T. Tran, Ruchi A. Patel, Amogh Chariyamane, Ratna B. Ray   +3 more
wiley   +1 more source

Nitric oxide-induced activation of the AMP-activated protein kinase alpha2 subunit attenuates IKappaB kinase activity and inflammatory responses in endothelial cells [PDF]

, 2011
Background: In endothelial cells, activation of the AMP-activated protein kinase (AMPK) has been linked with anti-inflammatory actions but the events downstream of kinase activation are not well understood.
Beß, Elke, Fißlthaler, Beate, Fleming, Ingrid, Frömel, Timo   +3 more
core  

Non-steroidal anti-inflammatory drugs (NSAIDs) and organ damage: A current perspective

Biochemical Pharmacology, 2020
Samik Bindu, Somnath Mazumder, U. Bandyopadhyay   +2 more
semanticscholar   +1 more source

Neurotoxic amyloid β‐peptide and tau produce cytokine‐like effects on PMCA in glioblastoma cell lines, enhancing its activity and isoforms expression

FEBS Open Bio, EarlyView.
Two biomarkers of Alzheimer's disease, amyloid β‐peptide (Aβ) and tau, induce the transformation of U‐251 and other glioblastoma cell lines into neurotoxic A1‐like reactive astrocytes. This transformation is produced by cytokines and is followed by upregulation of PMCA activity and isoform expression, and is closely associated with inflammation, as ...
María Berrocal, Alberto Alvarez‐Barrientos, Ana M. Mata   +2 more
wiley   +1 more source

Ginsenoside Rg1 protects against aging-induced renal interstitial fibrosis due to inhibition of tubular epithelial cells endoplasmic reticulum stress in SAMP8 mice

Journal of Functional Foods, 2020
Aging has become a primary cause of chronic kidney diseases, which ultimately progress to renal interstitial fibrosis. Endoplasmic reticulum (ER) stress has been reported to participate in tubular epithelial cells injury.
Shixin Ding, Han Zhang, Zhenghao Sun, Yuli Han, Yan Li, Xianan Dong, Yanyan Yin, Weiping Li, Weizu Li   +8 more
doaj  

Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1

Nature, 2018
E. Mills, D. Ryan, H. Prag, D. Dikovskaya, Deepthi Menon, Z. Zaslona, Mark P. Jedrychowski, Ana S. H. Costa, M. Higgins, E. Hams, John Szpyt, M. Runtsch, M. King, J. McGouran, R. Fischer, B. Kessler, A. F. Mcgettrick, M. Hughes, R. Carroll, Lee M. Booty, Elena V. Knatko, P. Meakin, M. Ashford, Louise K Modis, Gino Brunori, D. Sévin, P. Fallon, S. Caldwell, Edmund R. S. Kunji, Edward T. Chouchani, C. Frezza, A. Dinkova-Kostova, R. Hartley, M. Murphy, L. O’Neill   +34 more
semanticscholar   +1 more source

Pharmacology of 1, 3-diphenyl-5-(2-dimethylaminopropionylamino) pyrazole _??_AP. 14_??_, a new potent analgesic anti-inflammatory agent

, 1969
Tsutom KAMEYAMA, Kyoko OYANAGI, Ken‐ichi Sasaki, Kensuke Kisara   +3 more
openalex   +2 more sources

The impact of frailty syndrome on skeletal muscle histology: preventive effects of exercise

FEBS Open Bio, EarlyView.
Frailty syndrome exacerbates skeletal muscle degeneration via increased ECM deposition and myofiber loss. This study, using a murine model, demonstrates that endurance exercise attenuates these histopathological alterations, preserving muscle integrity. Findings support exercise as a viable strategy to counteract frailty‐induced musculoskeletal decline
Fujue Ji, Hae Sung Lee, Haesung Lee, Jong‐Hee Kim   +3 more
wiley   +1 more source