Results 181 to 190 of about 96,642 (272)

Primary non-response in inflammatory arthritis treated with biologics and targeted therapies in daily clinical practice. [PDF]

open access: yesTher Adv Musculoskelet Dis
Leon L   +7 more
europepmc   +1 more source

A Retrospective Analysis of PK and Response of Oral Ibuprofen in the Treatment of a Patent Ductus Arteriosus in Extremely Low Gestational Age Neonates

open access: yesThe Journal of Clinical Pharmacology, EarlyView.
Abstract Oral ibuprofen is the preferred pharmacotherapeutic option for treatment of a persistent patent ductus arteriosus (PDA), but evidence for its optimal use in extremely low gestational age newborns (ELGANs) remains limited. In the current study, we aimed to investigate the pharmacokinetics and exposure‐response relationship of oral ibuprofen in ...
Mohd Asif   +6 more
wiley   +1 more source

Serum vitamin D concentration is inversely associated with matrix metalloproteinase‐9 level in periodontal diseases

open access: yesJournal of Periodontology, EarlyView.
Abstract Background The aim of this study was to investigate the potential association between vitamin D deficiency and matrix metalloproteinase‐9 (MMP‐9) levels in gingival crevicular fluid (GCF) across various periodontal health and disease statuses.
Yeşim Ayhan Yıldırım   +4 more
wiley   +1 more source

Have we hit the JAK‐pot? Success of selective JAK 1 inhibitor following failure of pan‐JAK inhibitor in refractory pediatric ulcerative colitis

open access: yesJPGN Reports, EarlyView.
Abstract The treatment options available for pediatric ulcerative colitis (UC) are challenging due to few with Federal Drug Administration approval. Newer medications approved for adults include additional biologics with differing mechanisms of action and small molecule drugs, such as Janus kinase (JAK) inhibitors.
Jessica A. Black, Brad Pasternak
wiley   +1 more source

Upadacitinib for difficult‐to‐treat paediatric Crohn's disease

open access: yesJPGN Reports, EarlyView.
Abstract Paediatric‐onset inflammatory bowel disease (IBD) has an enormous impact on healthcare systems as it translates to a lifetime of healthcare. Since the approval of anti‐tumour necrosis factor‐alpha agents, it has become evident that in the long journey of paediatric IBD, there is an absolute need for more treatment options.
N. Nedelkopoulou   +3 more
wiley   +1 more source

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