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Pharmacokinetics of Non‐Steroidal Anti‐Inflammatory Agents
Australian and New Zealand Journal of Medicine, 1978Summary: Pharmacokinetics of non‐steroidal anti‐inflammatory agents. G. D. Champion and G. G. Graham, Aust. N.Z. J. Med., 1978, 8, Suppl. 1, pp 94–100. The non‐steroidal anti‐inflammatory drugs (NSAID) are well absorbed from the gastrointestinal tract. The only known exception is aspirin.
G D, Champion, G G, Graham
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Pain control: Non-steroidal anti-inflammatory agents
Seminars in Fetal and Neonatal Medicine, 2006The non-steroidal anti-inflammatory drugs (NSAIDs) and acetaminophen (paracetamol) are the most common analgesic drugs used in neonates and infants despite limited pharmacodynamic data. Both drugs act through inhibition of cyclooxygenase enzymes. Neonatal acetaminophen clearance is reduced in premature neonates (0.7 L h(-1) x 70 kg(-1)) and increases ...
Evelyne, Jacqz-Aigrain +1 more
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Non Steroidal Anti-Inflammatory and Anti-Allergy Agents
Current Medicinal Chemistry, 2002Non steroidal anti-inflammatory drugs (NSAIDs) are among the most commonly used for inflammation therapy. The major drawback in using the NSAIDs is in their tendency to cause gastrointestinal toxicity. Since the roles of arachidonic acid (A.A) metabolites, as leukotrienes (Lts), prostaglandins (PGs) and thromboxanes (TXA(2)) as mediators of the ...
C A, Kontogiorgis +1 more
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Comparative toxicity of non-steroidal anti-inflammatory agents
Pharmacology & Therapeutics, 1994Comparative toxicity of non-steroidal anti-inflammatory drugs was assessed using the Stanford Toxicity Index consisting of weighted symptoms, laboratory abnormalities and hospitalizations in 2976 consecutively enrolled rheumatoid arthritis patients from eight data bank centers with 27,936 patient-years of observation.
G, Singh +3 more
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The chemistry of non-steroidal anti-inflammatory agents
Pure and Applied Chemistry, 1969Abstract
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[Non-steroidal anti-inflammatory agents].
La Revue du praticien, 2003Non steroidal anti-inflammatory drugs have the highest rate of prescription in the world due to their efficacy in counteracting inflammation, pain, fever and blood clot (with low-dose aspirin). This therapeutic class has been recently widen by a new family of NSAID, namely COX-2 selective inhibitors or coxibs.
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The regulatory control of non-steroidal anti-inflammatory agents
European Journal of Clinical Pharmacology, 1981The number of marketed non-steroidal anti-inflammatory agents varies widely from one European country to another, partly as a consequence of differing regulatory policies. During a four-year period, nine of 18 applications to market such drugs in the Netherlands failed; the remaining nine compounds were all licenced; in all, 22 single drug entities of ...
M N, Dukes, I, Lunde
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Chapter 19. Non-steroidal Anti-inflammatory Agents
1969Publisher Summary This chapter elaborates studies analyzing non-steroidal anti-inflammatory agents. The importance of the circulating lymphocyte in association with the auto-immune component of adjuvant disease was shown by studies with heterologous antirat lymphocyte serum which prevents secondary responses to complete adjuvant. The RNA/DNA ratio of
Karl J. Doebel +5 more
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