Results 101 to 110 of about 696,361 (266)

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

EVALUATION OF ANTI-INFLAMMATORY ACTIVITY OF MESALAMINE BY GRBC STABILISATION ASSAY METHOD

The objective of the study is to evaluate the anti-inflammatory potential of Mesalamine using the Goat Red Blood Cell membrane stabilization assay. Inflammation is a complex biological response to harmful stimuli and NSAIDs play a crucial role in managing inflammatory conditions.
Sruthi K., Fahida T., Faseela Thasni K. F., Nandana Unnikrishnan C. K.*   +3 more
openaire   +1 more source

A Systematic Review and Meta‐Analysis of the Recurrence of Autoimmune Encephalitis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Autoimmune encephalitis (AE) is a disease with a potential for recurrence, and patients receive immunotherapy to prevent it. However, there is no consensus on the duration of immunotherapy. This study aimed to determine the recurrence rate and identify the risk factors for AE to provide guidance on the duration of immunotherapy ...
Shangkai Bai, Sen Zhang, Haipei Zhang, Yating Zhang, Junhong Guo, Xiaoyan Yang   +5 more
wiley   +1 more source

Green synthesis of silver nanoparticles using Nigella sativa with 0.1% of thymoquinone and evaluation of its anti-inflammatory and antioxidant activities – An in vitro study

Journal of Indian Society of Periodontology
Background: The therapeutic potential of herbs in treating various diseases is gaining recognition due to their promising outcomes and minimal side effects.
Leslie Rani Sthanislas, Bagavad Gita Jayaraman, Gautham Kumar Nandhakumar, C. S. Krishnan, Gowri Shankar Nattuthurai, Menaka Vasudevan, Savithri Nediyaparambu Krishnakumar, Noblin Shyma   +7 more
doaj   +1 more source

ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan, Yan Jiang, Yuxuan Yong, Tianshuo Zhang, Niannian Zhang, Qianqian Zeng, Xue Gong, Li Meng, Fangfang Bi, Yongmin Liu   +9 more
wiley   +1 more source

Anti-inflammatory activity of Curcuma wanenlueanga Saensouk, Thomudtha & Boonma rhizomes and the search for its bioactive markers by harmonizing bioassay-guided isolation and network pharmacology

BMC Complementary Medicine and Therapies
Background Rhizomes of Curcuma wanenlueanga Saensouk, Thomudtha & Boonma have been used in Thai traditional medicine and are included as an ingredient in a Thai traditional liniment formula listed by the Ministry of Public Health of Thailand for treating
Wisuwat Thongphichai, Hasriadi Hasriadi, Peththa Wadu Dasuni Wasana, Sanith Sri Jayashan, Boonchoo Sritularak, Pasarapa Towiwat, Suchada Sukrong   +6 more
doaj   +1 more source

Erythroxylum argentinum: Assays for anti-inflammatory activity

Journal of Ethnopharmacology, 1988
Zuanazzi, José Angelo Silveira, Chaves, Celia Machado Gervasio, Schapoval, Elfrides Eva Scherman, Diehl, Eliana Elisabeth, SIQUEIRA, N.C.S. DE, Henriques, Amelia Teresinha   +5 more
openaire   +3 more sources

[18F]Fluorodeprenyl‐D2 PET as a Tool to Monitor Disease Activity in GAD65‐Ab Autoimmune Encephalitis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To evaluate [18F]fluorodeprenyl‐D2 ([18F]F‐DED) positron‐emission tomography (PET) imaging as a biomarker of disease activity in autoimmune encephalitis (AIE) associated with glutamic acid decarboxylase 65 (GAD65) antibodies. Methods [18F]F‐DED PET was performed in 25 GAD65‐AIE patients and 8 controls using dynamic (0–60 min) and ...
Julia S. Dorneich, Jonathan A. Gernert, Hanna Zimmermann, Lisa Tagnin, Marianthi Zeinaki, Laura Sanzo, Letizia Vogler, Elisabeth Kaufmann, Justina Dargvainiene, Frank Leypoldt, Gérard N. Bischof, Robert Perneczky, Boris‐Stephan Rauchmann, Simon Lindner, Günter U. Höglinger, Rudolf A. Werner, Martin Kerschensteiner, Tania Kümpfel, Matthias Brendel, Franziska S. Thaler   +19 more
wiley   +1 more source

Understanding Further the Phenotypic Spectrum of Central Nervous System Inflammatory Demyelinating Disorders Using Unsupervised Clustering

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Central nervous system (CNS) inflammatory demyelinating syndromes, including multiple sclerosis (MS), aquaporin‐4 antibody–positive neuromyelitis optica spectrum disorder (AQP4 + NMOSD), and myelin oligodendrocyte glycoprotein (MOG) antibody–associated disease (MOGAD), occasionally overlap.
Bade Gulec, Elif Everest, Melih Tutuncu, Ugur Bilge, Sabahattin Saip, Ugur Uygunoglu, Aksel Siva   +6 more
wiley   +1 more source

Fucosterol’s modulatory effects on interleukin-6 and interleukin-1β: insights from molecular docking and lipopolysaccharide-induced HEK293 cells and zebrafish embryos

Fisheries and Aquatic Sciences
Chronic inflammatory diseases remain among the leading causes of death worldwide, highlighting the need for safer and more cost-effective anti-inflammatory agents from natural resources.
Rickson Gaspe, Junie Billones, Agnes Llamasares-Castillo   +2 more
doaj   +1 more source