Results 1 to 10 of about 2,225,872 (191)

CP-25 exerts a protective effect against ConA-induced hepatitis via regulating inflammation and immune response

Frontiers in Pharmacology, 2022
Hepatitis is a complex multifactorial pathological disorder, which can eventually lead to liver failure and even potentially be life threatening. Paeoniflorin-6′-O-benzene sulfonate (CP-25) has proven to have critical anti-inflammatory effects in ...
Nan Li, Jing-Jing Wu, Jing-Jing Wu, Meng Qi, Zi-Ying Wang, Sheng-Nan Zhang, Xiu-Qin Li, Ting-Ting Chen, Mei-Fang Wang, Ling-Ling Zhang, Wei Wei, Wu-Yi Sun   +11 more
doaj   +1 more source

sTNFRII-Fc modification protects human UC-MSCs against apoptosis/autophagy induced by TNF-α and enhances their efficacy in alleviating inflammatory arthritis

Stem Cell Research & Therapy, 2021
Background Tumor necrosis factor (TNF)-α inhibitors represented by Etanercept (a fusion protein containing soluble TNF receptor II (sTNFRII) and the Fc segment of human IgG1) play a pivotal role in Rheumatoid arthritis (RA) treatment.
Yingjie Zhao, Xuezhi Yang, Siyu Li, Bingjie Zhang, Susu Li, Xinwei Wang, Yueye Wang, Chengyan Jia, Yan Chang, Wei Wei   +9 more
doaj   +1 more source

CP-25 inhibits the hyperactivation of rheumatic synoviocytes by suppressing the switch in Gαs-Gαi coupling to the β2-adrenergic receptor

Cell Communication and Signaling, 2023
In essence, the β2 adrenergic receptor (β2AR) plays an antiproliferative role by increasing the intracellular cyclic 3’,5’-adenosine monophosphate (cAMP) concentration through Gαs coupling, but interestingly, β2AR antagonists are able to effectively ...
Mingli Ge, Li Wu, Feng He, Yu Tai, Ruhong Fang, Dafei Han, Paipai Guo, Hao Liu, Yong Hu, Shenglin Xu, Wei Wei, Qingtong Wang   +11 more
doaj   +1 more source

GRK2 Mediates Macrophage Polarization by Regulating EP4-cAMP-pCREB Signaling in Ulcerative Colitis and the Therapeutic Effect of Paroxetine on Mice with DSS-Induced Colitis

Pharmaceuticals, 2023
G protein-coupled receptor kinase 2 (GRK2) is one of the cytosolic enzymes, and GRK2 translocation induces prostaglandin E2 receptor 4 (EP4) over-desensitization and reduces the level of cyclic adenosine monophosphate (cAMP) to regulate macrophage ...
Jiawei Zhang, Xianzheng Zhang, Mingdian Lu, Yan Chang, Qingtong Wang, Jiajie Tu, Huaxun Wu, Chun Wang, Zhongyang Hong, Maoming Xiong, Lihua Song, Wei Wei   +11 more
doaj   +1 more source

Design of an anti-inflammatory diet (ITIS diet) for patients with rheumatoid arthritis. [PDF]

, 2020
Background:Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease that affects synovial joints, leading to inflammation, joint destruction, loss of function, and disability.
Agustín-Perez, Meritxall, Bustamante, Marta F, Cedola, Francesca, Coras, Roxana, Golshan, Shahrokh, Guma, Monica, Narasimhan, Rekha   +6 more
core   +2 more sources

Gα12 and Gα13: Versatility in Physiology and Pathology

Frontiers in Cell and Developmental Biology, 2022
G protein-coupled receptors (GPCRs), as the largest family of receptors in the human body, are involved in the pathological mechanisms of many diseases.
Paipai Guo, Yu Tai, Manman Wang, Hanfei Sun, Lingling Zhang, Wei Wei, Yang K. Xiang, Yang K. Xiang, Qingtong Wang   +8 more
doaj   +1 more source

CP-25 ameliorates methotrexate induced nephrotoxicity via improving renal apoptosis and methotrexate excretion

Journal of Pharmacological Sciences, 2021
Paeoniflorin-6′-O-benzene sulfonate (CP-25) is a derivative of Paeoniflorin. We investigate beneficial effect of CP-25 on methotrexate (MTX) induced nephrotoxicity in rats.
Xiao Wei, Yijin Wu, Hao Tang, Bin Wang, Yong Wang, Wei Sun, James Asenso, Feng Xiao, Chun Wang   +8 more
doaj   +1 more source

Combination therapy of ginsenoside compound K and methotrexate was efficient in elimination of anaemia and reduction of disease activity in adjuvant-induced arthritis rats

Pharmaceutical Biology, 2020
Context Ginsenoside compound K (CK) has anti-inflammatory, immunoregulatory, and myelosuppressive protective effects. Methotrexate (MTX) is widely used in combination therapy for rheumatoid arthritis (RA). Objective To evaluate the effects of combination
Jingyu Chen, Wu Wang, Mengya Jiang, Mei Yang, Wei Wei   +4 more
doaj   +1 more source

New insights into the Lck-NF-κB signaling pathway

Frontiers in Cell and Developmental Biology, 2023
Lck is essential for the development, activity, and proliferation of T cells, which may contribute to pathological progression and development of human diseases, such as autoimmune disorders and cancers when functioning aberrantly.
Jing Zhang, Jing Zhang, Yu-Jing Wu, Xiao-Xi Hu, Wei Wei   +4 more
doaj   +1 more source

Circulating Pro- and Anti-Inflammatory Metabolites and Its Potential Role in Rheumatoid Arthritis Pathogenesis. [PDF]

, 2020
Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease that affects synovial joints, leading to inflammation, joint destruction, loss of function, and disability.
Coras, Roxana, Guma, Monica, Murillo-Saich, Jessica D   +2 more
core   +2 more sources