Results 41 to 50 of about 4,511,051 (310)

Bridelia ferruginea Produces Anti-neuroinflammatory Activity through Inhibition of Nuclear Factor-kappa B and p38 MAPK Signalling [PDF]

, 2012
Bridelia ferruginea is commonly used in traditional African medicine (TAM) for treating various inflammatory conditions. Extracts from the plant have been shown to exhibit anti-inflammatory property in a number of in vivo models.
Aderogba, Mutallib A., Fiebich, Bernd L., Aderogba, Mutalib A., Okorji, Uchechukwu P., Okorji, U. P., Fiebich, B.L., Olajide, Olumayokun A., Olajide, Olumayokun A.; id_orcid   +7 more
core   +1 more source

Immunological characterization of the HIV-tuberculosis associated immune reconstitution inflammatory syndrome [PDF]

, 2011
While the integration of anti-TB and cART therapies is associated with substantial clinical improvement in the majority of patients, HIV-Tuberculosis associated Immune Reconstitution Inflammatory Syndrome (TB-IRIS) has been shown to occur in a ...
Tadokera, Rabecca
core   +1 more source

Inhibition of NLRP1 inflammasome improves autophagy dysfunction and Aβ disposition in APP/PS1 mice

Behavioral and Brain Functions, 2023
Increasing evidence has shown that the NOD-like receptor protein 1 (NLRP1) inflammasome is associated with Aβ generation and deposition, which contributes to neuronal damage and neuronal-inflammation in Alzheimer's disease (AD).
Xuewang Li, Han Zhang, Liu Yang, Xianan Dong, Yuli Han, Yong Su, Weiping Li, Weizu Li   +7 more
doaj   +1 more source

Ginsenoside Rg1 treatment alleviates renal fibrosis by inhibiting the NOX4–MAPK pathway in T2DM mice

Renal Failure, 2023
Diabetic kidney disease (DKD) is a severe complication of type 2 diabetes mellitus (T2DM). However, the pathogenesis of DKD remains unclear, and effective treatment strategies are still lacking. Ginsenoside Rg1 (Rg1) has been reported to improve DKD, but
Pengmin Ji, Qifeng Shi, Yan Liu, Min Han, Yong Su, Ran Sun, Huimin Zhou, Weizu Li, Weiping Li   +8 more
doaj   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

The Utility of serological markers in inflammatory bowel diseases: Gadget or magic? [PDF]

, 2008
The panel of serologic markers for inflammatory bowel diseases (IBD) is rapidly expanding. Anti–Saccharomyces cerevisiae antibodies (ASCA) and atypical perinuclear antineutrophil cytoplasmic antibodies (P-ANCA) remain the most widely investigated ...
Papp, Mária, Lakatos, Péter László, Norman, G. L., Altorjay, István   +3 more
core  

Nonsteroidal Anti-Inflammatory Drugs and Ectodomain Shedding of the Amyloid Precursor Protein [PDF]

, 2008
Background: Epidemiological studies have suggested that long-term use of nonsteroidal anti-inflammatory drugs (NSAIDs) is associated with a reduced incidence of Alzheimer's disease (AD).
Hermann Esselmann, Julia Ness, Leuchtenberger, Stefanie, Maler, Juan, Pietrzik, Claus U., Esselmann, Hermann, Sascha Weggen, Ness, Julia, Stefan F. Lichtenthaler, Czirr, Eva, Claus U. Pietrzik, Jens Wiltfang, Lichtenthaler, Stefan F., Stefanie Leuchtenberger, Weggen, Sascha, Juan Maler, Wiltfang, Jens, Eva Czirr   +17 more
core   +1 more source

Chronic glucocorticoid exposure activates BK-NLRP1 signal involving in hippocampal neuron damage

Journal of Neuroinflammation, 2017
Background Neuroinflammation mediated by NLRP1 (nucleotide-binding oligomerization domain (NOD)-like receptor protein 1) inflammasome plays an important role in many neurological diseases such as Parkinson’s disease (PD) and Alzheimer’s disease (AD). Our
Biqiong Zhang, Yaodong Zhang, Wenning Wu, Tanzhen Xu, Yanyan Yin, Junyan Zhang, Dake Huang, Weizu Li   +7 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source