Results 21 to 30 of about 4,511,051 (310)

IGFBP2 drives epithelial-mesenchymal transition in hepatocellular carcinoma via activating the Wnt/β-catenin pathway

Infectious Agents and Cancer, 2023
Metastasis has emerged as a major impediment to achieve successful therapeutic outcomes in hepatocellular carcinoma (HCC). Nonetheless, the intricate molecular mechanisms governing the progression of HCC remain elusive.
Xiu Chen, Yu Zhang, Pingping Zhang, Mengzhu Wei, Tian Tian, Yanling Guan, Chenchen Han, Wei Wei, Yang Ma   +8 more
doaj   +1 more source

IgD/FcδR is involved in T-cell acute lymphoblastic leukemia and regulated by IgD-Fc-Ig fusion protein

Pharmacological Research, 2023
T-cell acute lymphoblastic leukemia (T-ALL) has a poor prognosis as a result of severe immunosuppression and rapid tumor progression with resistance to conventional chemotherapy.
Yujing Wu, Aijun Zhang, Wensheng Chen, Qianling Xin, Wenwen Pan, Xiaoxi Hu, Tao Li, Hengshi Chen, Jing Zhang, Chengxin Luan, Jian Ge, Wei Wei   +11 more
doaj   +1 more source

NLRP3 inflammasome activation mechanism and its role in autoimmune liver disease

Acta Biochimica et Biophysica Sinica, 2022
The NLRP3 inflammasome is a multiprotein binding compound comprising NLRP3, connector protein ASC, and effector protein pro-caspase-1. When the NLRP3 inflammasome senses a danger signal from the host or pathogen, activated caspase-1 cleaves the ...
Guan Yanling, Gu Yiyue, Li Hao, Liang Bo, Han Chenchen, Zhang Yu, Liu Qian, Wei Wei, Ma Yang   +8 more
doaj   +1 more source

Vagus Nerve Stimulation in Refractory Epilepsy: Effects on Pro- and Anti-Inflammatory Cytokines in Peripheral Blood [PDF]

, 2010
Objective: The vagus nerve has important immunological functions that may be relevant for its anticonvulsive action. We postulate that this anticonvulsive action is activated by a shift in the immune system resulting in a reduction of neurotoxic and an ...
J.S.H. Vles, Schwarz, J.M., Berfelo, M. W., M. Schwarz, Vles, J. S. H., Schwarz, M., Hulsman, J. A. R. J., A. Myint, Majoie, H. J. M., M.W. Berfelo, Hulsman, J.A.R.J., K. Rijkers, Myint, A., J.A.R.J. Hulsman, Rijkers, K., H.J.M. Majoie   +15 more
core   +1 more source

Anti-Inflammatory Cytokines Predominate in Acute Human Plasmodium knowlesi Infections. [PDF]

, 2011
Plasmodium knowlesi has entered the human population of Southeast Asia. Naturally acquired knowlesi malaria is newly described with relatively little available data, including data on the host response to infection.
Parker-Williams, J, Timothy Planche, Cox-Singh, J, Planche, Timothy, Parker-Williams John, Parker-Williams, John, Daneshvar, C., Daneshvar, C, Singh Balbir, Cox-Singh, Janet, Balbir, Singh, Singh, Balbir, Daneshvar, Cyrus, Janet Cox-Singh, Singh, B, Balbir Singh, Daneshvar Cyrus, Cox-Singh Janet, Krishna Sanjeev, Planche, T, Cox Singh, Janet, Sanjeev, Krishna, John Parker-Williams, Cox-Singh, J., Krishna, S, Sanjeev Krishna, Planche Timothy, Krishna, Sanjeev, Cyrus Daneshvar, Cox Singh, Janet; id_orcid   +29 more
core   +2 more sources

Risk of acute myocardial infarction with nonselective non-steroidal anti-inflammatory drugs: a meta-analysis [PDF]

, 2006
The use of cyclo-oxygenase 2 selective nonsteroidal anti-inflammatory drugs (NSAIDs) is associated with increased risk of acute myocardial infarction (AMI). The association between the risks of AMI with nonselective NSAIDs is less clear.
Madhok, R., Langhorne, P., Wu, O., Singh, G., Rajan Madhok, Gurkirpal Singh, Olivia Wu, Peter Langhorne   +7 more
core   +1 more source

Ginsenoside Rg1 alleviates Aβ deposition by inhibiting NADPH oxidase 2 activation in APP/PS1 mice

Journal of Ginseng Research, 2021
Background: Ginsenoside Rg1 (Rg1), an active ingredient in ginseng, may be a potential agent for the treatment of Alzheimer’s disease (AD). However, the protective effect of Rg1 on neurodegeneration in AD and its mechanism of action are still ...
Han Zhang, Yong Su, Zhenghao Sun, Ming Chen, Yuli Han, Yan Li, Xianan Dong, Shixin Ding, Zhirui Fang, Weiping Li, Weizu Li   +10 more
doaj   +1 more source

Thymulin: An emerging anti-inflammatory molecule

, 2005
Thymulin is a neuroendocrine hormone with immunoregulatory actions. Originally known as 'serum thymic factor' (FTS), thymulin binds to a carrier protein and zinc (Zn2+) to exert its biologic properties.
Haddad J.J., Safieh-Garabedian B., Saade N.E.   +2 more
core   +1 more source

The Effects of MicroRNAs on Key Signalling Pathways and Epigenetic Modification in Fibroblast-Like Synoviocytes of Rheumatoid Arthritis

Mediators of Inflammation, 2018
MicroRNAs (miRNAs) are small noncoding RNAs that regulate gene expression at the posttranscriptional level via direct binding to the 3′-untranslated region (UTR) of target mRNAs.
Wenming Hong, Pengying Zhang, Xinming Wang, Jiajie Tu, Wei Wei   +4 more
doaj   +1 more source

MicroRNAs in Microglia: How do MicroRNAs Affect Activation, Inflammation, Polarization of Microglia and Mediate the Interaction Between Microglia and Glioma?

Frontiers in Molecular Neuroscience, 2019
The essential roles of microglia in maintaining homeostasis in the healthy brain and contributing to neuropathology are well documented. Emerging evidence suggests that epigenetic modulation regulates microglial behavior in both physiological and ...
Yawei Guo, Wenming Hong, Wenming Hong, Xinming Wang, Pengying Zhang, Heinrich Körner, Jiajie Tu, Wei Wei   +7 more
doaj   +1 more source