Results 21 to 30 of about 1,638,731 (268)

Are statins anti-inflammatory? [PDF]

Trials, 2000
Large scale clinical trials demonstrate significant reductions in cardiovascular event rates with statin therapy. The observed benefit of statin therapy, however, may be larger in these trials than that expected on the basis of lipid lowering alone. Emerging evidence from both clinical trials and basic science studies suggest that statins have anti ...
Blake, Gavin J., Ridker, Paul
openaire   +5 more sources

The Effects of MicroRNAs on Key Signalling Pathways and Epigenetic Modification in Fibroblast-Like Synoviocytes of Rheumatoid Arthritis

Mediators of Inflammation, 2018
MicroRNAs (miRNAs) are small noncoding RNAs that regulate gene expression at the posttranscriptional level via direct binding to the 3′-untranslated region (UTR) of target mRNAs.
Wenming Hong, Pengying Zhang, Xinming Wang, Jiajie Tu, Wei Wei   +4 more
doaj   +1 more source

MicroRNAs in Microglia: How do MicroRNAs Affect Activation, Inflammation, Polarization of Microglia and Mediate the Interaction Between Microglia and Glioma?

Frontiers in Molecular Neuroscience, 2019
The essential roles of microglia in maintaining homeostasis in the healthy brain and contributing to neuropathology are well documented. Emerging evidence suggests that epigenetic modulation regulates microglial behavior in both physiological and ...
Yawei Guo, Wenming Hong, Wenming Hong, Xinming Wang, Pengying Zhang, Heinrich Körner, Jiajie Tu, Wei Wei   +7 more
doaj   +1 more source

Ontology and Function of Fibroblast-Like and Macrophage-Like Synoviocytes: How Do They Talk to Each Other and Can They Be Targeted for Rheumatoid Arthritis Therapy?

Frontiers in Immunology, 2018
Fibroblast-like synoviocytes (FLS) and macrophage-like synoviocytes (MLS) are the two main cellular components of the synovium. It has been widely reported that FLS and MLS play essential roles in the joint pathology of rheumatoid arthritis (RA ...
Jiajie Tu, Wenming Hong, Wenming Hong, Pengying Zhang, Xinming Wang, Xinming Wang, Heinrich Körner, Wei Wei   +7 more
doaj   +1 more source

Ginsenoside Rg1 treatment protects against cognitive dysfunction via inhibiting PLC–CN–NFAT1 signaling in T2DM mice

Journal of Ginseng Research, 2023
Background: As a complication of Type II Diabetes Mellitus (T2DM), the etiology, pathogenesis, and treatment of cognitive dysfunction are still undefined.
Xianan Dong, Liangliang Kong, Lei Huang, Yong Su, Xuewang Li, Liu Yang, Pengmin Ji, Weiping Li, Weizu Li   +8 more
doaj   +1 more source

The Role of CTHRC1 in Regulation of Multiple Signaling and Tumor Progression and Metastasis

Mediators of Inflammation, 2020
Collagen triple helix repeat containing-1 (CTHRC1) has been identified as cancer-related protein. CTHRC1 expresses mainly in adventitial fibroblasts and neointimal smooth muscle cells of balloon-injured vessels and promotes cell migration and tissue ...
Dan Mei, Yue Zhu, Lingling Zhang, Wei Wei   +3 more
doaj   +1 more source

The application of HER2 and CD47 CAR-macrophage in ovarian cancer

Journal of Translational Medicine, 2023
Background The chimeric antigen receptor (CAR)-T therapy has a limited therapeutic effect on solid tumors owing to the limited CAR-T cell infiltration into solid tumors and the inactivation of CAR-T cells by the immunosuppressive tumor microenvironment ...
Yizhao Chen, Xiangling Zhu, Hanze Liu, Cunzhi Wang, Yu Chen, Huihui Wang, Yilong Fang, Xuming Wu, Yuting Xu, Chunhua Li, Xinyue Lv, Jinghua Huang, Xintong Han, Ruilin Li, Wenming Hong, Zhiying Yu, Wei Wei, Jiajie Tu   +17 more
doaj   +1 more source

Long non-coding RNAs: Potential therapeutic targets for epilepsy

Frontiers in Neuroscience, 2022
Epilepsy is a common and disastrous neurological disorder characterized by abnormal firing of neurons in the brain, affecting about 70 million people worldwide.
Sen Liu, Sen Liu, Sen Liu, Min Fan, Min Fan, Min Fan, Meng-Die Ma, Meng-Die Ma, Meng-Die Ma, Jin-Fang Ge, Jin-Fang Ge, Jin-Fang Ge, Fei-Hu Chen, Fei-Hu Chen, Fei-Hu Chen   +14 more
doaj   +1 more source

Sustained Therapeutic Efficacy of Intravenous Plasminogen Concentrate in Pediatric Patients With Type 1 Plasminogen Deficiency: An Analysis of Dosing Parameters and Clinical Outcomes

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Type 1 plasminogen deficiency (PLGD‐1) is an ultra‐rare autosomal recessive disorder caused by variants in the PLG gene and affects approximately 1.6 individuals per million. The condition is characterized by decreased plasminogen levels and impaired function, resulting in fibrin‐rich lesions on mucous membranes throughout the body.
Charles Nakar, Karen Thibaudeau, Mary Mathias, Heather McDaniel, Madlen Reschke, Klaus Tenbrock, Joseph M. Parker, Amy Shapiro   +7 more
wiley   +1 more source

Inhibition of NLRP1 inflammasome improves autophagy dysfunction and Aβ disposition in APP/PS1 mice

Behavioral and Brain Functions, 2023
Increasing evidence has shown that the NOD-like receptor protein 1 (NLRP1) inflammasome is associated with Aβ generation and deposition, which contributes to neuronal damage and neuronal-inflammation in Alzheimer's disease (AD).
Xuewang Li, Han Zhang, Liu Yang, Xianan Dong, Yuli Han, Yong Su, Weiping Li, Weizu Li   +7 more
doaj   +1 more source