Results 11 to 20 of about 4,294,591 (308)

Peripheral Anti-nociceptive and Anti-inflammatory Effect of OleanoliAcid in a Rat Model of Osteoarthritis [PDF]

, 2021
Background: Oleanolic acid (OA) is a naturally occurring pentacyclic triterpenoid with multifarious actions. The anti-inflammatory effect it exerts when taken orally is the most important; however, the underpinning mechanisms of such effects have not yet
Fouani, Malak, Fakhoury, Marc, Salman, Israa, Lawand, Nada Bashir   +3 more
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Anti-inflammatory Agent

, 2023
There is accumulating evidence that rice bran extracts have profound effects on mediating inflammation, with the therapeutic potential of rice bran widely explored in several chronic inflammatory conditions including asthma, diabetes, obesity, dermatitis,
Jason Ashworth (23880816)
openaire   +3 more sources

Identification of phytoconstituents of Tragia involucrata leaf extracts and evaluate their correlation with anti-inflammatory & antioxidant properties.

, 2021
AimsThe present investigation was aimed at exploring the phytoconstituents using Gas Chromatography Mass Spectroscopy and to evaluate antioxidant and anti-inflammatory properties of the leaf extracts.Materials and methodsThe extracts were obtained ...
Dua, K, Chellappan, DK, Velu, V, Radhakrishnan, V, Malipeddi, H, Kumar, N, Mehta, M, Fuloria, S, Gupta, G, Banerjee, S   +9 more
core   +1 more source

MicroRNA-10b promotes arthritis development by disrupting CD4+ T cell subtypes

Molecular Therapy: Nucleic Acids, 2022
Rheumatoid arthritis (RA) is an inflammation-involved disorder and features the disruption of CD4+ T lymphocytes. Herein, we describe that microRNA-10b-5p (miR-10b) promotes RA progression by disrupting the balance between subsets of CD4+ T cells.
Jiajie Tu, Dafei Han, Yilong Fang, Haifeng Jiang, Xuewen Tan, Zhen Xu, Xinming Wang, Wenming Hong, Tao Li, Wei Wei   +9 more
doaj   +1 more source

Combination therapy of ginsenoside compound K and methotrexate was efficient in elimination of anaemia and reduction of disease activity in adjuvant-induced arthritis rats

Pharmaceutical Biology, 2020
Context Ginsenoside compound K (CK) has anti-inflammatory, immunoregulatory, and myelosuppressive protective effects. Methotrexate (MTX) is widely used in combination therapy for rheumatoid arthritis (RA). Objective To evaluate the effects of combination
Jingyu Chen, Wu Wang, Mengya Jiang, Mei Yang, Wei Wei   +4 more
doaj   +1 more source

Synovial Macrophages in Rheumatoid Arthritis: The Past, Present, and Future

Mediators of Inflammation, 2020
The ontogeny of macrophages in most organs has already been established. Owing to the limited number and inaccessibility of synovial macrophages (SMs), the origin of SMs has not been fully elucidated.
Jiajie Tu, Xinming Wang, Xun Gong, Wenming Hong, Dafei Han, Yilong Fang, Yawei Guo, Wei Wei   +7 more
doaj   +1 more source

The Regulatory Effects of Paeoniflorin and Its Derivative Paeoniflorin-6′-O-Benzene Sulfonate CP-25 on Inflammation and Immune Diseases

Frontiers in Pharmacology, 2019
The plant extract “total glucosides of peony” (TGP) constitutes a mixture of glycosides that is isolated from the roots of the well-known traditional Chinese herb Paeonia lactiflora Pall.
Jiajie Tu, Yawei Guo, Wenming Hong, Wenming Hong, Yilong Fang, Dafei Han, Pengying Zhang, Xinming Wang, Heinrich Körner, Wei Wei   +9 more
doaj   +1 more source

Targeted inhibition of GRK2 kinase domain by CP-25 to reverse fibroblast-like synoviocytes dysfunction and improve collagen-induced arthritis in rats

Acta Pharmaceutica Sinica B, 2021
Rheumatoid arthritis (RA) is an autoimmune disease and is mainly characterized by abnormal proliferation of fibroblast-like synoviocytes (FLS). The up-regulated cellular membrane expression of G protein coupled receptor kinase 2 (GRK2) of FLS plays a ...
Chenchen Han, Yifan Li, Yuwen Zhang, Yang Wang, Dongqian Cui, Tingting Luo, Yu Zhang, Qian Liu, Hao Li, Chun Wang, Dexiang Xu, Yang Ma, Wei Wei   +12 more
doaj   +1 more source

Ontogeny of Synovial Macrophages and the Roles of Synovial Macrophages From Different Origins in Arthritis

Frontiers in Immunology, 2019
The ontogeny of macrophages in most organ/tissues in human body has been proven. Due to the limited number and inaccessibility of synovial macrophages (SM), the origin of SM has not been fully illuminated.
Jiajie Tu, Wenming Hong, Wenming Hong, Yawei Guo, Pengying Zhang, Yilong Fang, Xinming Wang, Xinming Wang, Xiaoyun Chen, Shanshan Lu, Wei Wei   +10 more
doaj   +1 more source

Risk of acute myocardial infarction with nonselective non-steroidal anti-inflammatory drugs: a meta-analysis [PDF]

, 2006
The use of cyclo-oxygenase 2 selective nonsteroidal anti-inflammatory drugs (NSAIDs) is associated with increased risk of acute myocardial infarction (AMI). The association between the risks of AMI with nonselective NSAIDs is less clear.
Madhok, R., Langhorne, P., Wu, O., Singh, G.   +3 more
core   +1 more source