Results 11 to 20 of about 2,225,971 (290)

Immune-Cell-Based Therapy for COVID-19: Current Status

open access: yesViruses, 2023
Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has become a global pandemic. The interplay between innate and adaptive immune responses plays a crucial role in managing COVID-19.
Yiyuan Wang   +7 more
doaj   +1 more source

Anti‐Inflammatory Natural Products [PDF]

open access: yesMediators of Inflammation, 2015
Inflammation is the first biological response of the immune system against infection or irritation. However, accumulating epidemiological and clinical study indicates that zealous acute inflammation or chronic inflammatory reaction is a significant risk factor to develop various human diseases.
Yifu Yang   +3 more
openaire   +3 more sources

Novel antioxidant and anti-inflammatory peptides from the Siamese crocodile (Crocodylus siamensis) hemoglobin hydrolysate [PDF]

open access: yes, 2017
Novel antioxidant and anti-inflammatory peptides were isolated from hydrolysates of Siamese crocodile (Crocodylus siamensis) hemoglobin. C. siamensis hemoglobin hydrolysates (CHHs) were obtained by pepsin digestion at different incubation times (2, 4, 6,
Jangpromma, Nisachon   +7 more
core   +1 more source

Molecular Mechanisms of T Cells Activation by Dendritic Cells in Autoimmune Diseases

open access: yesFrontiers in Pharmacology, 2018
The interaction between T cell and dendritic cells (DCs) that leads to T cell activation affects the progression of the immune response including autoimmune diseases. Antigen presentation on immune cell surface, formation of an immunological synapse (IS),
Yu Tai   +5 more
doaj   +1 more source

Synovial Macrophages in Rheumatoid Arthritis: The Past, Present, and Future

open access: yesMediators of Inflammation, 2020
The ontogeny of macrophages in most organs has already been established. Owing to the limited number and inaccessibility of synovial macrophages (SMs), the origin of SMs has not been fully elucidated.
Jiajie Tu   +7 more
doaj   +1 more source

MicroRNA-10b promotes arthritis development by disrupting CD4+ T cell subtypes

open access: yesMolecular Therapy: Nucleic Acids, 2022
Rheumatoid arthritis (RA) is an inflammation-involved disorder and features the disruption of CD4+ T lymphocytes. Herein, we describe that microRNA-10b-5p (miR-10b) promotes RA progression by disrupting the balance between subsets of CD4+ T cells.
Jiajie Tu   +9 more
doaj   +1 more source

The glucocorticoid receptor in inflammatory processes : transrepression is not enough [PDF]

open access: yes, 2015
Glucocorticoids (GCs) are the most commonly used anti-inflammatory agents to treat inflammatory and immune diseases. However, steroid therapies are accompanied by severe side-effects during long-term treatment. The dogma that transrepression of genes, by
Dejager, Lien   +3 more
core   +2 more sources

Bidirectional Role of β2-Adrenergic Receptor in Autoimmune Diseases

open access: yesFrontiers in Pharmacology, 2018
Disorder of the sympathetic nervous system (SNS) is closely related to the pathogenesis of various autoimmune diseases (ADs). Catecholamine triggered beta2-adrenergic receptor (β2-AR) signaling is important in creating a bidirectional response in the ...
Li Wu   +9 more
doaj   +1 more source

IGFBP2 drives epithelial-mesenchymal transition in hepatocellular carcinoma via activating the Wnt/β-catenin pathway

open access: yesInfectious Agents and Cancer, 2023
Metastasis has emerged as a major impediment to achieve successful therapeutic outcomes in hepatocellular carcinoma (HCC). Nonetheless, the intricate molecular mechanisms governing the progression of HCC remain elusive.
Xiu Chen   +8 more
doaj   +1 more source

Targeted inhibition of GRK2 kinase domain by CP-25 to reverse fibroblast-like synoviocytes dysfunction and improve collagen-induced arthritis in rats

open access: yesActa Pharmaceutica Sinica B, 2021
Rheumatoid arthritis (RA) is an autoimmune disease and is mainly characterized by abnormal proliferation of fibroblast-like synoviocytes (FLS). The up-regulated cellular membrane expression of G protein coupled receptor kinase 2 (GRK2) of FLS plays a ...
Chenchen Han   +12 more
doaj   +1 more source

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