Results 1 to 10 of about 4,822,589 (177)

JQ1 Inhibits the Hyperproliferation and Aggressiveness of Fibroblast‐Like Synoviocytes in Rheumatoid Arthritis via Regulating IL7R [PDF]

Immunity, Inflammation and Disease
Background Rheumatoid arthritis (RA) is a chronic autoimmune bone disease. BRD4 is implicated in the pathogenesis of bone disorders. This study aimed to investigate the effects of a BRD4 inhibitor JQ1 on RA.
Lin Hong, Tingting Chen, Yuchen Jiang, Xiaohua Zhang   +3 more
doaj   +3 more sources

Ebosin Attenuates the Inflammatory Responses Induced by TNF-α through Inhibiting NF-κB and MAPK Pathways in Rat Fibroblast-Like Synoviocytes

Journal of Immunology Research, 2022
Tumor necrosis factor-α (TNF-α) lies at the apex of signal transduction cascades that results in induced destruction of joints in rheumatoid arthritis. It is therefore of great medicinal interest to modulate the cellular responses to TNF-α.
Yang Zhang, Lifei Wang, Liping Bai, Rong Jiang, Jianbo Wu, Yuan Li   +5 more
doaj   +2 more sources

MicroRNA-340-5p suppressed rheumatoid arthritis synovial fibroblast proliferation and induces apoptotic cell number by targeting signal transducers and activators of transcription 3

Autoimmunity, 2020
Rheumatoid arthritis is a chronic systemic autoimmune disease. In this study, the role of microRNA-340-5p in rheumatoid arthritis was investigated. qRT-PCR was used to detect the expression of microRNA-340-5p in serums, synovial tissues, and fibroblast ...
Shibin Zhang, Tingting Meng, Chunzhi Tang, Shengdong Li, Xudong Cai, Dawei Wang, Min Chen   +6 more
doaj   +2 more sources

PLSCR1 Regulates the Physiology of Fibroblast‐Like Synoviocytes via Modulating the STAT1 Signaling Pathway [PDF]

Immunity, Inflammation and Disease
Background Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by synovial inflammation and joint destruction. Elucidating the molecular mechanisms underlying the pathogenesis is crucial for identifying novel therapeutic targets ...
Tianhua Chen, Jiaojiao Wang
doaj   +2 more sources

Signalling and putative therapeutic molecules on the regulation of synoviocyte signalling in rheumatoid arthritis

Bone & Joint Research, 2021
Rheumatoid arthritis (RA) is an autoimmune disease characterized by symmetrical and chronic polyarthritis. Fibroblast-like synoviocytes are mainly involved in joint inflammation and cartilage and bone destruction by inflammatory cytokines and matrix ...
Minjeong Ji, Hee Jung Ryu, Jeong Hee Hong   +2 more
doaj   +1 more source

Systems-biology analysis of rheumatoid arthritis fibroblast-like synoviocytes implicates cell line-specific transcription factor function

Nature Communications, 2022
Fibroblast-like synoviocytes (FLS) are used as a model of rheumatoid arthritis synoviocytes, although cell lines derived from individual patients can have heterogeneous biology.
Richard I. Ainsworth, Deepa Hammaker, Gyrid Nygaard, Cecilia Ansalone, Camilla Machado, Kai Zhang, Lina Zheng, Lucy Carrillo, Andre Wildberg, Amanda Kuhs, Mattias N. D. Svensson, David L. Boyle, Gary S. Firestein, Wei Wang   +13 more
doaj   +1 more source

Shikonin attenuates rheumatoid arthritis by targeting SOCS1/JAK/STAT signaling pathway of fibroblast like synoviocytes

Chinese Medicine, 2021
Background Rheumatoid arthritis is a progressive and systemic autoimmune disease seriously compromises human health. Fibroblast like synoviocytes are the major effectors of proliferation and inflammation in rheumatoid arthritis synovial tissue.
Lianhua He, Huijie Luan, Juan He, Miaomiao Zhang, Qingxia Qin, Yiping Hu, Yueming Cai, Desheng Sun, Yu Shi, Qingwen Wang   +9 more
doaj   +1 more source

CCL22 induces pro-inflammatory changes in fibroblast-like synoviocytes

iScience, 2021
Summary: Synovitis is common in patients with osteoarthritis (OA) and is associated with pain and disease progression. We have previously demonstrated that the chemokine C-C motif chemokine 22 (CCL22) induces chondrocyte apoptosis in vitro; however, the ...
Guomin Ren, Nedaa Al-Jezani, Pamela Railton, James N. Powell, Roman J. Krawetz   +4 more
doaj   +1 more source

Lasp1 regulates adherens junction dynamics and fibroblast transformation in destructive arthritis

Nature Communications, 2021
Fibroblast-like synoviocytes are important mediators of joint pathology in rheumatoid arthritis (RA). Here the authors show that Lasp1 is epigenetically regulated and highly expressed by these cells in RA and its deletion can limit joint pathology in a ...
Denise Beckmann, Anja Römer-Hillmann, Annika Krause, Uwe Hansen, Corinna Wehmeyer, Johanna Intemann, David J. J. de Gorter, Berno Dankbar, Jan Hillen, Marianne Heitzmann, Isabell Begemann, Milos Galic, Toni Weinhage, Dirk Foell, Rizi Ai, Joachim Kremerskothen, Hans P. Kiener, Sylvia Müller, Thomas Kamradt, Christopher Schröder, Elsa Leitão, Bernhard Horsthemke, Philip Rosenstiel, Karl Nordström, Gilles Gasparoni, Nina Gasparoni, Jörn Walter, Na Li, Xinyi Yang, Ho-Ryun Chung, Hermann Pavenstädt, Nico Lindemann, Hans J. Schnittler, Wei Wang, Gary S. Firestein, Thomas Pap, Adelheid Korb-Pap   +36 more
doaj   +1 more source

Treatment with FAP-targeted zinc ferrite nanoparticles for rheumatoid arthritis by inducing endoplasmic reticulum stress and mitochondrial damage

Materials Today Bio, 2023
Rheumatoid arthritis (RA) is a common chronic inflammatory disease characterized by the proliferation of fibroblast-like synoviocytes (FLS), pannus development, cartilage, and bone degradation, and, eventually, loss of joint function.
Weizhong Qi, Li Jin, Cuixi Wu, Hao Liao, Mengdi Zhang, Zhaohua Zhu, Weiyu Han, Qiyue Chen, Changhai Ding   +8 more
doaj   +1 more source