Results 1 to 10 of about 18,476 (229)
Comprehensive epigenetic landscape of rheumatoid arthritis fibroblast-like synoviocytes [PDF]
Nature Communications, 2018 Fibroblast-like synoviocytes (FLS) in the intimal layer of the synovium can become invasive and destroy cartilage in patients with rheumatoid arthritis (RA).
Rizi Ai +18 more
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Fibroblast-like synoviocytes orchestrate daily rhythmic inflammation in arthritis [PDF]
Open BiologyRheumatoid arthritis is a chronic inflammatory disease that shows characteristic diurnal variation in symptom severity, where joint resident fibroblast-like synoviocytes (FLS) act as important mediators of arthritis pathology.
Polly Downton +4 more
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CCL22 induces pro-inflammatory changes in fibroblast-like synoviocytes [PDF]
iScience, 2021 Summary: Synovitis is common in patients with osteoarthritis (OA) and is associated with pain and disease progression. We have previously demonstrated that the chemokine C-C motif chemokine 22 (CCL22) induces chondrocyte apoptosis in vitro; however, the ...
Guomin Ren +4 more
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PLSCR1 Regulates the Physiology of Fibroblast‐Like Synoviocytes via Modulating the STAT1 Signaling Pathway [PDF]
Immunity, Inflammation and DiseaseBackground Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by synovial inflammation and joint destruction. Elucidating the molecular mechanisms underlying the pathogenesis is crucial for identifying novel therapeutic targets ...
Tianhua Chen, Jiaojiao Wang
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The LKB1–AMPK Signaling Axis Modulates Ferroptosis in Fibroblast-Like Synoviocytes Derived from Rheumatoid Arthritis [PDF]
BiomedicinesBackground/Objectives: Ferroptosis is a type of regulated cell death that involves iron-dependent accumulation of lipid peroxides. Because fibroblast-like synoviocytes (FLSs) in patients with rheumatoid arthritis (RA) have a hyperplastic and inflammatory
Ha-Reum Lee +3 more
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Unveiling the Therapeutic Potential: Targeting Fibroblast-like Synoviocytes in Rheumatoid Arthritis [PDF]
Expert Reviews in Molecular MedicineRheumatoid arthritis (RA) is a systemic autoimmune disease characterized by chronic inflammation of the synovial membrane, leading to cartilage destruction and bone erosion.
Siran Yue +10 more
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Journal of Immunology Research, 2022 Tumor necrosis factor-α (TNF-α) lies at the apex of signal transduction cascades that results in induced destruction of joints in rheumatoid arthritis. It is therefore of great medicinal interest to modulate the cellular responses to TNF-α.
Yang Zhang +5 more
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Bone & Joint Research, 2021 Rheumatoid arthritis (RA) is an autoimmune disease characterized by symmetrical and chronic polyarthritis. Fibroblast-like synoviocytes are mainly involved in joint inflammation and cartilage and bone destruction by inflammatory cytokines and matrix ...
Minjeong Ji +2 more
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Nature Communications, 2022 Fibroblast-like synoviocytes (FLS) are used as a model of rheumatoid arthritis synoviocytes, although cell lines derived from individual patients can have heterogeneous biology.
Richard I. Ainsworth +13 more
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Chinese Medicine, 2021 Background Rheumatoid arthritis is a progressive and systemic autoimmune disease seriously compromises human health. Fibroblast like synoviocytes are the major effectors of proliferation and inflammation in rheumatoid arthritis synovial tissue.
Lianhua He +9 more
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