Mediators of Inflammation, 2016 Human fibroblast-like synoviocytes play a vital role in joint synovial inflammation in rheumatoid arthritis (RA). Proinflammatory cytokines induce fibroblast-like synoviocyte activation and dysfunction.
Xinjing Luo +6 more
doaj +2 more sources
陆军军医大学学报Objective To identify the hub gene of fibroblast-like synoviocytes in rheumatoid arthritis (RA) and verify its impact on proliferation, migration and invasion of the cells.
LEI Lei, LYU Yuxin, ZHANG Jing
doaj +2 more sources
Ontology and Function of Fibroblast-Like and Macrophage-Like Synoviocytes: How Do They Talk to Each Other and Can They Be Targeted for Rheumatoid Arthritis Therapy? [PDF]
Frontiers in Immunology, 2018 Fibroblast-like synoviocytes (FLS) and macrophage-like synoviocytes (MLS) are the two main cellular components of the synovium. It has been widely reported that FLS and MLS play essential roles in the joint pathology of rheumatoid arthritis (RA ...
Jiajie Tu +7 more
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Solute carrier nutrient transporters in rheumatoid arthritis fibroblast-like synoviocytes [PDF]
Frontiers in Immunology, 2022 Metabolomic studies show that rheumatoid arthritis (RA) is associated with metabolic disruption. Metabolic changes in fibroblast-like synoviocytes (FLS) likely contribute to FLS abnormal response and strongly contribute to joint destruction.
Alyssa Torres +5 more
doaj +2 more sources
FOXO1, PXK, PYCARD and SAMD9L are differentially expressed by fibroblast-like cells in equine synovial membrane compared to joint capsule [PDF]
BMC Veterinary Research, 2017 Background The synovial membrane lines the luminal side of the joint capsule in synovial joints. It maintains joint homeostasis and plays a crucial role in equine joint pathology.
Line Nymann Thomsen +4 more
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Comprehensive epigenetic landscape of rheumatoid arthritis fibroblast-like synoviocytes [PDF]
Nature Communications, 2018 Fibroblast-like synoviocytes (FLS) in the intimal layer of the synovium can become invasive and destroy cartilage in patients with rheumatoid arthritis (RA).
Rizi Ai +18 more
doaj +2 more sources
Fibroblast-like synoviocytes orchestrate daily rhythmic inflammation in arthritis [PDF]
Open BiologyRheumatoid arthritis is a chronic inflammatory disease that shows characteristic diurnal variation in symptom severity, where joint resident fibroblast-like synoviocytes (FLS) act as important mediators of arthritis pathology.
Polly Downton +4 more
doaj +3 more sources
Multi-Technique Integration Identifies O-GlcNAc Transferase in Fibroblast-Like Synoviocytes as a Therapeutic Target for Rheumatoid Arthritis. [PDF]
Adv Sci (Weinh)AI‑guided single‑cell transcriptomics identifies OGT as a key regulator enriched in rheumatoid arthritis fibroblast‑like synoviocytes (RA‐FLSs). Inflammatory stimuli activate the OGT–SAP130 axis, which modulates the H3K27ac/H3K27me3 balance and epigenetically silences BTG2, promoting aggressive transformation of RA‑FLSs.
Xie D +14 more
europepmc +2 more sources
AnimalsDuring acute ruminal acidosis, the manifestation of aseptic polysynovitis and lameness in cattle has been observed. Evidence suggests that joint inflammation can be attributed to the metabolic alterations induced by D-lactate in fibroblast-like ...
Stefanie Teuber +7 more
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Targeting fibroblast-like synoviocytes in rheumatoid arthritis [PDF]
, 2022 Fibroblast-like synoviocytes (FLS) are mesenchymal-derived cells that play an important role in the physiology of the synovium by producing certain components of the synovial fluid and articular cartilage.
Firestein, Gary S, Tsaltskan, Vladislav
core +1 more source