Results 11 to 20 of about 18,476 (229)
Expression of interleukin-18 receptor in fibroblast-like synoviocytes [PDF]
Arthritis Research & Therapy, 2001 An excess of the proinflammatory substance IL-18 is present in joints of patients with rheumatoid arthritis (RA), and expression of IL-18 receptor (IL-18R) regulates IL-18 bioactivity in various cell types.
Möller, Burkhard +7 more
core +6 more sources
Iguratimod Inhibits the Aggressiveness of Rheumatoid Fibroblast-Like Synoviocytes [PDF]
Journal of Immunology Research, 2019 Objective. Iguratimod, a novel disease-modifying anti-rheumatic drug for the treatment of rheumatoid arthritis, has been approved in China and Japan. Here, we aimed to find whether iguratimod can inhibit the aggressive behavior and promote apoptosis of ...
Jin Lin +12 more
doaj +3 more sources
Editorial: Immunomodulatory roles of fibroblast-like synoviocytes in rheumatoid arthritis [PDF]
Frontiers in ImmunologyYunhui Chen +5 more
doaj +4 more sources
Solute carrier nutrient transporters in rheumatoid arthritis fibroblast-like synoviocytes
Frontiers in Immunology, 2022 Metabolomic studies show that rheumatoid arthritis (RA) is associated with metabolic disruption. Metabolic changes in fibroblast-like synoviocytes (FLS) likely contribute to FLS abnormal response and strongly contribute to joint destruction.
Alyssa Torres +5 more
doaj +4 more sources
Targeting fibroblast-like synoviocytes in rheumatoid arthritis [PDF]
Current Opinion in Pharmacology, 2022 Fibroblast-like synoviocytes (FLS) are mesenchymal-derived cells that play an important role in the physiology of the synovium by producing certain components of the synovial fluid and articular cartilage. In rheumatoid arthritis (RA), however, fibroblasts become a key driver of synovial inflammation and joint damage.
Vladislav Tsaltskan, Gary S. Firestein
openaire +3 more sources
Insulin Exacerbates Inflammation in Fibroblast-Like Synoviocytes [PDF]
Inflammation, 2020 Abstract Osteoarthritis (OA) is considered the most frequent degenerative disease and is characterized by cartilage degradation and synovial inflammation. Fibroblast-like synoviocytes (FLSs) are vital to synovial inflammation in OA. Type 2 diabetes mellitus (T2DM) is characterized by insulin resistance and hyperinsulinemia (HINS) and has been ...
Li Qiao, Yi Li, Shui Sun
openaire +2 more sources
Simvastatin Induces Apoptosis of Fibroblast-Like Synoviocytes [PDF]
The Open Rheumatology Journal, 2009 Background: Statins (3-Hydroxy-3-methylglutaryl-CoA reductase inhibitors) exert favorable effects on lipoprotein metabolism, but appeared to possess anti-inflammatory properties among others, as suggested by their ability to inhibit collagen-induced arthritis in mice.
Litinsky, Ira +5 more
openaire +2 more sources
Epigenetic Alterations in Rheumatoid Arthritis Fibroblast-Like Synoviocytes [PDF]
Epigenomics, 2017 Rheumatoid arthritis is an immune-mediated disease that primarily affects diarthrodial joints. Susceptibility and severity of this disease are influenced by nongenetic factors, such as environmental stress, suggesting an important role of epigenetic changes.
Doody, Karen M +2 more
openaire +4 more sources
Autoimmunity, 2020 Rheumatoid arthritis is a chronic systemic autoimmune disease. In this study, the role of microRNA-340-5p in rheumatoid arthritis was investigated. qRT-PCR was used to detect the expression of microRNA-340-5p in serums, synovial tissues, and fibroblast ...
Shibin Zhang +6 more
doaj +1 more source
Lasp1 regulates adherens junction dynamics and fibroblast transformation in destructive arthritis
Nature Communications, 2021 Fibroblast-like synoviocytes are important mediators of joint pathology in rheumatoid arthritis (RA). Here the authors show that Lasp1 is epigenetically regulated and highly expressed by these cells in RA and its deletion can limit joint pathology in a ...
Denise Beckmann +36 more
doaj +1 more source