Results 31 to 40 of about 4,822,589 (177)

Epigenetic alterations in rheumatoid arthritis fibroblast-like synoviocytes [PDF]

, 2017
Rheumatoid arthritis is an immune-mediated disease that primarily affects diarthrodial joints. Susceptibility and severity of this disease are influenced by nongenetic factors, such as environmental stress, suggesting an important role of epigenetic ...
Doody, Karen M, Firestein, Gary S, Bottini, Nunzio, Karen M Doody, Nunzio Bottini, Gary S Firestein   +5 more
core   +1 more source

Pannus growth regulators as potential targets for biological therapy in rheumatoid arthritis

Современная ревматология, 2018
The main goal of treatment for rheumatoid arthritis (RA) is to suppress inflammation using basic and symptomatic therapies. At the same time, the above strategy does not significantly stop joint  destruction that leads to disability in patients.
A. S. Mikhaylova, O. M. Lesnyak
doaj   +1 more source

An overview of carbonic anhydrases and membrane channels of synoviocytes in inflamed joints

Journal of Enzyme Inhibition and Medicinal Chemistry, 2019
The highly aggressive fibroblast-like synoviocytes (FLSs) are inflammatory mediators involved in synovial joint destruction. Membrane channels and transporters are essential components of the cell migration apparatus and are involved in various cellular ...
Min Jeong Ji, Jeong Hee Hong
doaj   +1 more source

Localization, Shedding, Regulation and Function of Aminopeptidase N/CD13 on Fibroblast like Synoviocytes. [PDF]

PLoS ONE, 2016
Aminopeptidase N/CD13 is highly expressed by fibroblast like synoviocytes (FLS) and may play a role in rheumatoid arthritis (RA). CD13 was previously detected in human synovial fluid where it was significantly increased in RA compared to osteoarthritis ...
Rachel L Morgan, Nilofar Behbahani-Nejad, Judith Endres, M Asif Amin, Nick J Lepore, Yuxuan Du, Andrew Urquhart, Kevin C Chung, David A Fox   +8 more
doaj   +1 more source

TNF induces glycolytic shift in fibroblast like synoviocytes via GLUT1 and HIF1A

Scientific Reports, 2021
TNF is a central cytokine in the pathogenesis of rheumatoid arthritis (RA). Elevated level of TNF causes local inflammation that affects immune cells and fibroblast-like synoviocytes (FLS). Nowadays, only 20–30% of patients experience remission after the
Kathrin Koedderitzsch, Ekaterina Zezina, Lingzi Li, Matthias Herrmann, Nadine Biesemann   +4 more
doaj   +1 more source

Iguratimod Inhibits the Aggressiveness of Rheumatoid Fibroblast-Like Synoviocytes

Journal of Immunology Research, 2019
Objective. Iguratimod, a novel disease-modifying anti-rheumatic drug for the treatment of rheumatoid arthritis, has been approved in China and Japan. Here, we aimed to find whether iguratimod can inhibit the aggressive behavior and promote apoptosis of ...
Jin Lin, Ye Yu, Xuanwei Wang, Yini Ke, Chuanyin Sun, Lihuan Yue, Guanhua Xu, Bei Xu, Liqin Xu, Heng Cao, Danyi Xu, Nancy Olsen, Weiqian Chen   +12 more
doaj   +1 more source

Bioenergetic Materials for Tissue Regeneration: Modulating Metabolism to Promote Cellular Anabolism

Advanced Science, EarlyView.
Bioenergetic materials (BEMs) modulate cellular metabolism to promote tissue regeneration. Their principal mechanisms of action include metabolic substrate supplementation, metabolic enzyme modulation, organelle transfer, electrical current regulation, redox homeostasis modulation, and oxygen tension modulation.
Yuchen He, Yuwen Wang, Jonathan F. Gong, Yiting Lei, Fei Jin, Weihong Zhu, Rocky S. Tuan, Zhong Alan Li   +7 more
wiley   +1 more source

Generation of two hiPSC lines, (DMBi003-A and DMBi004-A), by reprogramming peripheral blood mononuclear cells and fibroblast-like synoviocytes from rheumatoid arthritis patients [PDF]

, 2022
Rheumatoid arthritis (RA) is a chronic inflammatory disease that primarily affects joints but should be considered as a syndrome that also includes extra-articular manifestations and comorbidities.
Piotr Wiland, Biniecka, Monika, Douglas Veale, Józef Dulak, Skoczyńska, Marta, Ursula Fearon, Marta Skoczyńska, Monika Biniecka, Kubiak, Grzegorz, Veale, Douglas, Jan Wolnik, Dulak, Józef, Wiland, Piotr, Wolnik, Jan, Fearon, Ursula, Grzegorz Kubiak   +15 more
core   +1 more source

Metabolic‐Redox Remodeling of Inflammatory Synovium by Mannose‐Modified Selenium Nanoparticles for Osteoarthritis Therapy

Advanced Science, EarlyView.
Elevated GLUT1‐driven glycolysis and disrupted selenoprotein‐dependent redox homeostasis drive osteoarthritic progression. Intra‐articular mannose‐modified selenium nanoparticles (M‐SeNPs) selectively target hypermetabolic synovial cells to reprogram aberrant glycolysis and restore endogenous antioxidant defenses.
Yu‐Qing Zou, Chen‐Hao Xu, Bo‐Wei Li, Leung Chan, Yi‐Di Xu, Han‐Bo Su, Rui Peng, Fang‐Ji Luo, Ya‐Chen Peng, Zhen‐Yan Li, Vincent Kam Wai Wong, Xiao‐Fei Zheng, Xing Ma, Zhen‐Gang Zha, Tianfeng Chen, Huan‐Tian Zhang   +15 more
wiley   +1 more source

Neutrophil Microvesicles from Healthy Control and Rheumatoid Arthritis Patients Prevent the Inflammatory Activation of Macrophages

EBioMedicine, 2018
Microvesicles (MVs) are emerging as a novel means to enact cell-to-cell communication in inflammation. Here, we aimed to ascertain the ability of neutrophil-derived MVs to modulate target cell behaviour, the focus being the macrophage.MVs were generated ...
Hefin I. Rhys, Francesco Dell'Accio, Costantino Pitzalis, Adrian Moore, Lucy V. Norling, Mauro Perretti   +5 more
doaj   +1 more source