Results 1 to 10 of about 99,394 (285)

Peficitinib Inhibits the Chemotactic Activity of Monocytes via Proinflammatory Cytokine Production in Rheumatoid Arthritis Fibroblast-Like Synoviocytes

Cells, 2019
Background: This study was performed to examine the effects of the Janus kinase (JAK) inhibitor peficitinib on fibroblast-like synoviocytes (FLS) obtained from patients with rheumatoid arthritis (RA). Methods: To examine the expression of JAK1, JAK2, and
Yuzo Ikari, Takeo Isozaki, Yumi Tsubokura, Tsuyoshi Kasama   +3 more
doaj   +1 more source

Human Adult Fibroblast‐like Synoviocytes and Articular Chondrocytes Exhibit Prominent Overlap in Their Transcriptomic Signatures

ACR Open Rheumatology, 2021
Objectives Fibroblast‐like synoviocytes (FLS) and articular chondrocytes (AC) derive from a common pool of embryonic precursor cells. They are currently believed to engage in largely distinct differentiation programs to build synovium and articular ...
Kyle Jones, Marco Angelozzi, Umesh Gangishetti, Abdul Haseeb, Charles deCharleroy, Véronique Lefebvre, Pallavi Bhattaram   +6 more
doaj   +1 more source

The presence of a positive blood culture should be regarded a risk factor for DAIR failure in cases of haematogenous total knee arthroplasty infection

Journal of Orthopaedics and Traumatology
Purpose Late acute haematogenous total knee arthroplasty (LAH TKA) infections represent approximately 20% of all prosthetic infections. Debridement, antibiotics, and implant retention (DAIR) is a widely accepted treatment; however, it carries a ...
G. Pedemonte-Parramón, E. Reynaga, S. Molinos, J. Díez de los Ríos, A. Vivero, E. García-Oltra, V. López-Pérez, R. Paredes, J. A. Hernández-Hermoso   +8 more
doaj   +1 more source

Angiotensin II type 2 receptor (AT2R) as a novel modulator of inflammation in rheumatoid arthritis synovium

Scientific Reports, 2017
Despite increasing evidence suggesting that angiotensin II type 2 receptor (AT2R) may regulate tissue inflammation, no study has yet analyzed its possible implication in rheumatoid arthritis (RA) synovitis.
Riccardo Terenzi, Mirko Manetti, Irene Rosa, Eloisa Romano, Felice Galluccio, Serena Guiducci, Lidia Ibba-Manneschi, Marco Matucci-Cerinic   +7 more
doaj   +1 more source

LKB1 Regulates Inflammation of Fibroblast-like Synoviocytes from Patients with Rheumatoid Arthritis via AMPK-Dependent SLC7A11-NOX4-ROS Signaling

Cells, 2023
Fibroblast-like synoviocytes (FLS) in rheumatoid arthritis (RA) patients have increased reactive oxygen species (ROS) levels and an impaired redox balance compared with FLS from control patients.
Ha-Reum Lee, Su-Jin Yoo, Jinhyun Kim, Seong Wook Kang   +3 more
doaj   +1 more source

Impact of a fracture liaison service on patient management after an osteoporotic fracture: the CHUV FLS

Swiss Medical Weekly, 2018
In 2008, the Centre Hospitalier Universitaire Vaudois (CHUV, Lausanne, Switzerland) initiated a Fracture Liaison Service (FLS). All patients hospitalised for a low trauma fracture are identified by the FLS.
Bérengère Aubry-Rozier, Delphine Stoll, Elena Gonzalez Rodriguez, Didier Hans, Veronique Prudent, Ariane Seuret, Alain Farron, Olivier Lamy   +7 more
doaj   +1 more source

Effects of Fracture Liaison Service on Outcomes of Patients with Hip Fracture in Rural Area of an Asian Country

Geriatric Orthopaedic Surgery & Rehabilitation, 2023
Introduction Fracture Liaison Services (FLS) has been proven effective in reducing subsequent fractures and related mortality. However, more research is needed on the impact of FLS on the 30-day readmission rate and its effectiveness in rural hospitals ...
Chien-Chieh Wang MD, Hsuan-Chih Liu MD, Ming-Tsung Lee PhD, Wen-Tsung Huang MD   +3 more
doaj   +1 more source

CypB-CD147 Signaling Is Involved in Crosstalk between Cartilage and FLS in Collagen-Induced Arthritis

Mediators of Inflammation, 2020
To investigate the crosstalk between cartilage and fibroblast-like synoviocytes (FLS) in rheumatoid arthritis (RA), we adopted an in vitro coculture system model of collagen-induced arthritis (CIA) cartilage and CIA FLS monolayer.
Qishan Wang, Bingxin Xu, Kaijian Fan, Jing Wu, Tingyu Wang   +4 more
doaj   +1 more source

Localization, Shedding, Regulation and Function of Aminopeptidase N/CD13 on Fibroblast like Synoviocytes. [PDF]

PLoS ONE, 2016
Aminopeptidase N/CD13 is highly expressed by fibroblast like synoviocytes (FLS) and may play a role in rheumatoid arthritis (RA). CD13 was previously detected in human synovial fluid where it was significantly increased in RA compared to osteoarthritis ...
Rachel L Morgan, Nilofar Behbahani-Nejad, Judith Endres, M Asif Amin, Nick J Lepore, Yuxuan Du, Andrew Urquhart, Kevin C Chung, David A Fox   +8 more
doaj   +1 more source

Cyclic GMP-AMP Synthase Is Required for Cell Proliferation and Inflammatory Responses in Rheumatoid Arthritis Synoviocytes

Mediators of Inflammation, 2015
Rheumatoid arthritis (RA) is characterized by inflammatory cell infiltration, fibroblast-like synoviocytes (FLS) invasive proliferation, and joint destruction. Cyclic GMP-AMP synthase (cGAS) is a cytosolic DNA sensor that induces immune activation.
Yan Wang, Guo-Hua Su, Fang Zhang, Jing-Xue Chu, Yun-Shan Wang   +4 more
doaj   +1 more source