Results 11 to 20 of about 99,394 (285)

Soluble factors released from fibroblast-like synoviocytes of JIA patients with future extended course can condition persistent JIA synovial fibroblasts for increased IL-6 production [PDF]

Arthritis Research & Therapy
Background Juvenile Idiopathic Arthritis (JIA) includes a subset of oligoarticular patients who later extend to a polyarticular course (extended-to-be, ETB), resulting in worse outcomes. Predictors of extension remain poorly defined.
Megan M. Simonds, Lina Al-Jaberi, Hermine I. Brunner, AnneMarie C. Brescia   +3 more
doaj   +2 more sources

Virtual beam generation and guidance command calculation in FLS advanced approach process

Xibei Gongye Daxue Xuebao, 2021
FLS approach is an effective means to improve approach perception and reduce operational risk, and it is one of the key functions of flight management system of advanced commercial aircraft.
Zhai Shaobo, Li Guangwen, Xue Guanglong, Jia Qiuling, Sun Xiaomin   +4 more
doaj   +1 more source

Effects of integrase inhibitor-based antiretroviral therapy on brain outcomes according to time since acquisition of HIV-1 infection

Scientific Reports, 2021
Integrase strand transfer inhibitors (INSTI) are a main component of the current antiretroviral regimens recommended for treatment of HIV infection. However, little is known about the impact of INSTI on neurocognition and neuroimaging.
Anna Prats, Ignacio Martínez-Zalacaín, Beatriz Mothe, Eugènia Negredo, Núria Pérez-Álvarez, Maite Garolera, Sira Domènech-Puigcerver, Pep Coll, Michael Meulbroek, Anna Chamorro, Carmina R. Fumaz, Maria J. Ferrer, Bonaventura Clotet, Carles Soriano-Mas, Jose A. Muñoz-Moreno   +14 more
doaj   +1 more source

The cell as secret agent—autonomy and intelligence of the living cell: driving force of development

Academia Biology, 2023
The related disciplines of ecology and evolution pay little heed to the essential driver of development, the single living cell. We cannot comprehend the realities of population dynamics and evolutionary impetus without the cell being at the ...
Brian J. Ford
doaj   +1 more source

MiR-300 promotes the proliferation, migration and invasion of fibroblast-like synoviocytes in rheumatoid arthritis by targeting IL-37

Autoimmunity, 2022
Background Fibroblast-like synoviocytes (FLS) are crucial regulators in the pathogenesis of rheumatoid arthritis (RA). Reportedly, microRNA (miR) participates in regulating the pathogenesis of RA.
Ying Wang, Ge Zhang, Wei Huang
doaj   +1 more source

Exosomes derived from synovial fibroblasts from patients with rheumatoid arthritis promote macrophage migration that can be suppressed by miR-124-3p

Heliyon, 2023
Objectives: Exosomes are potent vehicles for intercellular communication. Rheumatoid arthritis (RA) is a chronic systemic disease of unknown etiology. Local administration of miR-124 precursor to rats with adjuvant-induced arthritis suppresses systemic ...
Yuji Nakamachi, Kenichi Uto, Shinya Hayashi, Takaichi Okano, Akio Morinobu, Ryosuke Kuroda, Seiji Kawano, Jun Saegusa   +7 more
doaj   +1 more source

The synovial fluid fibroblast-like synoviocyte: A long-neglected piece in the puzzle of rheumatoid arthritis pathogenesis

Frontiers in Immunology, 2022
Rheumatoid arthritis (RA) is a systemic autoimmune disease during which fibroblast-like synoviocytes (FLS) contribute to both joint inflammation and destruction. FLS represent the core component of the synovial membrane.
Dorra Elhaj Mahmoud, Dorra Elhaj Mahmoud, Wajih Kaabachi, Nadia Sassi, Lamjed Tarhouni, Sonia Rekik, Samia Jemmali, Hela Sehli, Maryam Kallel-Sellami, Elhem Cheour, Lilia Laadhar   +10 more
doaj   +1 more source

High-dose intravenous immunoglobulins might modulate inflammation in COVID-19 patients

Life Science Alliance, 2021
High-dose of IVIG show immunomodulatory properties that may be useful for controlling the hyperinflammatory status observed in COVID-19 patients. The use of high-dose of intravenous immunoglobulins (IVIGs) as immunomodulators for the treatment of COVID ...
María Luisa Rodríguez de la Concepción, Erola Ainsua-Enrich, Esteban Reynaga, Carlos Ávila-Nieto, Jose Ramón Santos, Silvia Roure, Lourdes Mateu, Roger Paredes, Jordi Puig, Juan Manuel Jimenez, Nuria Izquierdo-Useros, Bonaventura Clotet, María Luisa Pedro-Botet, Jorge Carrillo   +13 more
doaj   +1 more source

Phenotypic and functional characterization of synovial fluid-derived fibroblast-like synoviocytes in rheumatoid arthritis

Scientific Reports, 2021
Fibroblast-like synoviocytes (FLS) play an important pathological role in persistent inflammatory joint diseases such as rheumatoid arthritis (RA). These cells have primarily been characterized in the RA synovial membrane.
Ditte Køster, Johanne Hovgaard Egedal, Søren Lomholt, Malene Hvid, Martin R. Jakobsen, Ulf Müller-Ladner, Hermann Eibel, Bent Deleuran, Tue Wenzel Kragstrup, Elena Neumann, Morten Aagaard Nielsen   +10 more
doaj   +1 more source

Elevated fatty acid β-oxidation by leptin contributes to the proinflammatory characteristics of fibroblast-like synoviocytes from RA patients via LKB1-AMPK pathway

Cell Death and Disease, 2023
Fibroblast-like synoviocytes (FLS) maintain chronic inflammation leading to joint destruction in rheumatoid arthritis (RA). Fatty acid β-oxidation (FAO) regulates cell function.
Jing Wei, Xinxin Huang, Xing Zhang, Guanghong Chen, Cheng Zhang, Xinyang Zhou, Jingjing Qi, Yan Zhang, Xia Li   +8 more
doaj   +1 more source