Results 41 to 50 of about 30,676 (298)

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source

Human Adult Fibroblast‐like Synoviocytes and Articular Chondrocytes Exhibit Prominent Overlap in Their Transcriptomic Signatures

ACR Open Rheumatology, 2021
Objectives Fibroblast‐like synoviocytes (FLS) and articular chondrocytes (AC) derive from a common pool of embryonic precursor cells. They are currently believed to engage in largely distinct differentiation programs to build synovium and articular ...
Kyle Jones, Marco Angelozzi, Umesh Gangishetti, Abdul Haseeb, Charles deCharleroy, Véronique Lefebvre, Pallavi Bhattaram   +6 more
doaj   +1 more source

MiR-30e-5p deficiency exerts an inhibitory effect on inflammation in rheumatoid arthritis via regulating Atl2 expression

Archives of Rheumatology, 2023
Objectives: This study aims to investigate the inflammatory effect of the microRNA (miRNA) miR-30e-5p on rheumatoid arthritis (RA) development in RA mice and fibroblast-like synoviocytes (FLS). Materials and methods: MiR-30e-5p and atlastin GTPase 2 (
Shanshan Liu*, Kai Wang*, Ju Li, Yan Liu, Zhongyuan Zhang, Deqian Meng   +5 more
doaj   +1 more source

Effect of synoviolin knockdown on apoptosis in RA FLS.

, 2013
RA FLS were nucleofected (amaxa) for 24 h with 0.5 µg of 4 synoviolin siRNA duplexes (S-01 to S-04), synoviolin smartpool siRNA duplex or siCONTROL siRNA (sictl) and synoviolin expression analysed by real-time RT-PCR (A, left panel) or Western Blot (A ...
Anne Tournadre (360940), Wim B. van den Berg (118337), Gary S. Firestein (360941), Myew-Ling Toh (360938), Marije I. Koenders (158627), David Boyle (221745), Yuan Zhou (179597), Erik Lubberts (26108), Gaelle Gonzales (360939), Pierre Miossec (3350)   +9 more
core   +1 more source

Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis

FEBS Letters, EarlyView.
This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng, Shen‐Shin Chang, Feng‐Wei Chen, Ying‐Chieh Su, Thanh Phuong Nguyen, Yu‐Wei Hsiao, Jhih‐Ying Chi, Hsin‐Yin Liang, Ju‐Ming Wang   +8 more
wiley   +1 more source

Tansy aphid data - Hugh D. Loxdale,FLS, 2007

, 2011
Tansy aphid data - Hugh D.
David G. Heckel (150629), Schöfl, Gerhard, Gerhard Schöfl (173061), Kerstin R. Wiesner (3323796), Franklin N. Nyabuga (3323802), Wiesner, Kerstin R., Weisser, Wolfgang W., Hugh D. Loxdale (3323799), Loxdale, Hugh D., Wolfgang W. Weisser (140915), Nyabuga, Franklin N., Heckel, David G.   +11 more
core   +1 more source

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

FEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source

Effects of Fracture Liaison Service on Outcomes of Patients with Hip Fracture in Rural Area of an Asian Country

Geriatric Orthopaedic Surgery & Rehabilitation, 2023
Introduction Fracture Liaison Services (FLS) has been proven effective in reducing subsequent fractures and related mortality. However, more research is needed on the impact of FLS on the 30-day readmission rate and its effectiveness in rural hospitals ...
Chien-Chieh Wang MD, Hsuan-Chih Liu MD, Ming-Tsung Lee PhD, Wen-Tsung Huang MD   +3 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Cytotoxic Effects of Dimethylamino Parthenolide on the Rheumatoid Arthritis Fibroblast-Like Synoviocytes Cell Line [PDF]

Research in Molecular Medicine
Background: Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease in which fibroblast-like synoviocytes (FLS) play a critical role in its pathogenesis.
Sara Sadeqi, Zahra Yazdani, Parisa Zafari, Salman Ghafari, Alireza Rafiei   +4 more
doaj