Results 31 to 40 of about 30,676 (298)

Single-cell analysis reveals heterogeneity of juvenile idiopathic arthritis fibroblast-like synoviocytes with implications for disease subtype

Arthritis Research & Therapy, 2022
Background Fibroblast-like synoviocytes (FLS) play a crucial role in JIA pathogenesis; however, the mechanisms by which they contribute to disease progression are not well described.
Megan M. Simonds, Kathleen E. Sullivan, AnneMarie C. Brescia   +2 more
doaj   +1 more source

Representation of Sickle Cell Disease Patients in Pediatric and Adult Care: What We Discovered Using Informatics for Integrating Biology and the Bedside (i2b2) Data

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Transitioning from pediatric to adult care is a high‐risk period for individuals with sickle cell disease (SCD). An initial observation at one academic medical center suggested a sex‐based disparity in clinic populations, prompting a national investigation.
Laurie J. Duckworth, Kholod Alhassan, Ada De La Osa, John Stephen, Yue Yao, Diana J. Wilkie   +5 more
wiley   +1 more source

Hepatic histological findings in the fatty liver Shionogi Wild (FLS W) mice and FLS ob/ob mice.

, 2016
A and B: HE staining (magnification: x 100) in FLS W and FLS ob/ob mice at 24 weeks of age, respectively. C and D: Sirius red staining (magnification: x100) in FLS W and FLS ob/ob mice at 24 weeks of age, respectively.
Kinya Okamoto (473649), Keisuke Hino (156607), Toshiaki Okamoto (2634997), Jun Kato (649096), Yuichi Hara (2391778), Takumi Onoyama (2635003), Manabu Kishina (2635000), Shiho Tokunaga (2634994), Yoshikazu Murawaki (156594), Masahiko Koda (2635006), Taka-aki Sugihara (2635009), Kenichi Miyoshi (473650)   +11 more
core   +1 more source

Uncovering Inequities: The Role of Social Determinants of Health in Hospitalized Adolescents and Young Adults With Heavy Menstrual Bleeding

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Heavy menstrual bleeding (HMB) is a common condition among adolescents and young adults (AYAs) and is the leading cause of iron deficiency anemia (IDA) in this population. Growing evidence suggests that social determinants of health (SDOH) influence menstrual bleeding patterns, access to care, and treatment. However, no studies have
Maria Carter‐Febres, Cristina Tarango, Ashley Childress, Chunyan Liu, Evan Thomas, Jennifer Pomales, Eric S. Mullins   +6 more
wiley   +1 more source

Influence of fibroblast-like synovial (FLS) cells on the expression of transient receptor potential V1 (TRPV1) receptor-like immunoreactivity in dorsal root ganglion (DRG) neurones

, 2011
Copyright information:Taken from "Fibroblast-like synovial cells from normal and inflamed knee joints differently affect the expression of pain-related receptors in sensory neurones: a co-culture study"http://arthritis-research.com/content/9/1 ...
Christina Rose (73302), Rolf Bräuer (8748), Hans-Georg Schaible (26029), Jonny Richter (73301), Gisela Segond von Banchet (26028), Marion Hückel (58654)   +5 more
core   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

FEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux, Christian Lévêque, Fodil Azzaz, Marion Sangiardi, Sarosh R Irani, Michael Seagar, Jacques Fantini, Oussama El Far   +7 more
wiley   +1 more source

The presence of a positive blood culture should be regarded a risk factor for DAIR failure in cases of haematogenous total knee arthroplasty infection

Journal of Orthopaedics and Traumatology
Purpose Late acute haematogenous total knee arthroplasty (LAH TKA) infections represent approximately 20% of all prosthetic infections. Debridement, antibiotics, and implant retention (DAIR) is a widely accepted treatment; however, it carries a ...
G. Pedemonte-Parramón, E. Reynaga, S. Molinos, J. Díez de los Ríos, A. Vivero, E. García-Oltra, V. López-Pérez, R. Paredes, J. A. Hernández-Hermoso   +8 more
doaj   +1 more source

Fig. 1, FLS phylogenetic tree

, 2022
FLS phylogenetic tree. TBLASTN search was conducted on Solanum lycopersicum, Nicotiana attenuata, Capsicum annuum, Capsicum annuum, Capsicum annuum, Solanum tuberosum, Oryza sativa Japonica group, Hordeum vulgare, Phaseolus vulgaris, Zea mays, Triticum ...
Marija Milosavljevic (12240821), Kim Kramers (12240824), Soren Pedersen (12218420), Maddie Kessler (12240968)   +3 more
core   +1 more source