Acid-sensing ion channel 3 decreases phosphorylation of extracellular signal-regulated kinases and induces synoviocyte cell death by increasing intracellular calcium. [PDF]
, 2014 IntroductionAcid-sensing ion channel 3 (ASIC3) is expressed in synoviocytes, activated by decreases in pH, and reduces inflammation in animal models of inflammatory arthritis.
Boyle, David L +6 more
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The synovial proteome: analysis of fibroblast-like synoviocytes [PDF]
Arthritis Res Ther, 2004 The present studies were initiated to determine the protein expression patterns of fibroblast-like synovial (FLS) cells derived from the synovia of rheumatoid arthritis patients. The cellular proteins were separated by two-dimensional polyacrylamide gel electrophoresis and the in-gel digested proteins were analyzed by matrix-assisted laser desorption ...
Dasuri, Kumar +7 more
openaire +3 more sources
The n-acetyl phenylalanine glucosamine derivative attenuates the inflammatory/catabolic environment in a chondrocyte-synoviocyte co-culture system [PDF]
, 2019 Osteoarthritis (OA), the most prevalent degenerative joint disease, still lacks a true disease-modifying therapy. The involvement of the NF-κB pathway and its upstream activating kinases in OA pathogenesis has been recognized for many years.
Borzi, R. M. +7 more
core +1 more source
Materials Today Bio, 2023 Rheumatoid arthritis (RA) is a common chronic inflammatory disease characterized by the proliferation of fibroblast-like synoviocytes (FLS), pannus development, cartilage, and bone degradation, and, eventually, loss of joint function.
Weizhong Qi +8 more
doaj +1 more source
Immunopathogenesis of rheumatoid arthritis [PDF]
, 2017 Rheumatoid arthritis (RA) is the most common inflammatory arthropathy. The majority of evidence, derived from genetics, tissue analyses, models, and clinical studies, points to an immune-mediated etiology associated with stromal tissue dysregulation that
Ahmed +115 more
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Circulating Pro- and Anti-Inflammatory Metabolites and Its Potential Role in Rheumatoid Arthritis Pathogenesis. [PDF]
, 2020 Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease that affects synovial joints, leading to inflammation, joint destruction, loss of function, and disability.
Coras, Roxana +2 more
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Role of Fibroblast Activation Protein Alpha in Fibroblast-like Synoviocytes of Rheumatoid Arthritis
Iranian Journal of Allergy, Asthma and Immunology, 2021 Fibroblast-like synoviocytes (FLSs) have been introduced in recent years as a key player in the pathogenesis of rheumatoid arthritis (RA), but the exact mechanisms of their transformation and intracellular pathways have not yet been determined.
Mohammad Javad Mousavi +10 more
doaj +1 more source
Autophagy generates citrullinated peptides in human synoviocytes: a possible trigger for anti-citrullinated peptide antibodies [PDF]
, 2016 OBJECTIVES: Autophagy may represent a functional processing event that creates a substrate for autoreactivity. In particular, autophagy may play a role in the pathogenesis of RA, since autophagy is a key cellular event involved in the generation of ...
Alessandra Nerviani +14 more
core +1 more source
IFN-gamma promotes fibroblast-like synoviocytes motility [PDF]
Annals of the Rheumatic Diseases, 2010 Rheumatoid arthritis (RA) is the most common chronic inflammatory joint disease. In RA, a systemic autoimmune response translates into an inflammatory attack on the synovium that yields the formation of an aggressive cell mass called pannus which attaches to, encroaches over and destroys the articular cartilage.
T Karonitsch +8 more
openaire +1 more source
Synoviocyte cultures from synovial fluid
Reumatismo, 2011 The study of the pathogenetic mechanisms of rheumatic diseases is in general carried out through “in vitro” systems based on cellular cultures models.
L. Punzi +7 more
doaj +1 more source