Alpha-2-Macroglobulin-Enriched Plasma Modulates Inflammatory and Proteolytic Pathways in Experimental Equine Musculoskeletal Models [PDF]
AnimalsJoint inflammation and extracellular matrix degradation are major contributors to the development of equine osteoarthritis and reduced athletic performance.
Enrico Gugliandolo +8 more
doaj +2 more sources
Tumor necrosis factor alpha triggers mitochondrial dysfunction and ROS-driven cytokine amplification in bovine fibroblast-like synoviocytes [PDF]
Frontiers in Veterinary ScienceLameness in dairy cattle, driven by joint inflammation, involves fibroblast-like synoviocytes (FLS) that produce inflammatory mediators and reactive oxygen species (ROS).
Natalia Andrea Godoy +10 more
doaj +2 more sources
An Overview of Carbonic Anhydrases and Membrane Channels of Synoviocytes in Inflamed Joints
Journal of Enzyme Inhibition and Medicinal Chemistry, 2019 The highly aggressive fibroblast-like synoviocytes (FLSs) are inflammatory mediators involved in synovial joint destruction. Membrane channels and transporters are essential components of the cell migration apparatus and are involved in various cellular ...
Min Jeong Ji, Jeong Hee Hong
exaly +2 more sources
The transcriptional atlas, intercellular communication, and metabolic reprogramming of the cartilage and synovium in osteoarthritis patients with diabetes mellitus: a multiomics study [PDF]
Bone & Joint ResearchAims: A strong correlation has been observed between diabetes mellitus (DM) with the pathogenesis of osteoarthritis (OA). This study aimed to elucidate the cellular and molecular mechanisms by which DM exacerbates OA, through multiomics analysis of ...
Yinxian Wen +9 more
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Bone and Joint Research, 2022 AimsTo explore the synovial expression of mucin 1 (MUC1) and its role in rheumatoid arthritis (RA), as well as the possible downstream mechanisms.MethodsPatients with qualified synovium samples were recruited from a RA cohort.
Lie Dai, Yaoyao Zou, Jinjian Liang
exaly +3 more sources
Kaempferol suppresses fibroblast-like synoviocyte proliferation in rheumatoid arthritis by targeting glutamate-cysteine ligase modifier subunit to inhibit ferroptosis resistance [PDF]
Bone & Joint ResearchAims: Kaempferol has demonstrated promising therapeutic potential in the treatment of rheumatoid arthritis (RA), yet its underlying mechanisms remain to be fully elucidated. This study aimed to investigate the role of kaempferol in modulating ferroptosis
Yi Ling +10 more
doaj +2 more sources
The use of animal models in rheumatoid arthritis research [PDF]
Journal of Yeungnam Medical Science, 2023 The pathological hallmark of rheumatoid arthritis (RA) is a synovial pannus that comprises proliferating and invasive fibroblast-like synoviocytes, infiltrating inflammatory cells, and an associated neoangiogenic response.
Jin-Sun Kong +2 more
doaj +1 more source
Frontiers in Immunology, 2022 We have recently provided new evidence for a role of p75NTR receptor and its preferential ligand proNGF in amplifying inflammatory responses in synovial mononuclear cells of chronic arthritis patients.
Luciapia Farina +18 more
doaj +1 more source
Bone & Joint Research, 2021 Rheumatoid arthritis (RA) is an autoimmune disease characterized by symmetrical and chronic polyarthritis. Fibroblast-like synoviocytes are mainly involved in joint inflammation and cartilage and bone destruction by inflammatory cytokines and matrix ...
Minjeong Ji +2 more
doaj +1 more source
Pharmaceutics, 2021 Osteoarthritis (OA) is a complex multi-target disease with an unmet medical need for the development of therapies that slow and potentially revert disease progression.
Carlota Salgado +2 more
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