Results 1 to 10 of about 30,224 (276)

Biodiversity-Driven Screening of Amphibian Skin Secretions for Inflammatory Modulation in Joint Diseases [PDF]

Toxins
This study explores the direct effects of amphibian skin secretions on human cells involved in joint diseases, aiming to identify species with potential for inflammatory modulation.
Douglas Souza Oliveira, César Alexandre, Miryam Paola Alvarez-Flores, Isadora Maria Villas-Boas, Hugo Vigerelli, Isabel de Fátima Correia Batista, Michelle Cristiane Bufalo, Nancy Starobinas, Flávio Lichtenstein, Rafael Marques-Porto, Marcus Buri, Viviane Portas-Lopes, Pedro Luiz Mailho-Fontana, Marta Maria Antoniazzi, Denise Vilarinho Tambourgi, Ana Marisa Chudzinski-Tavassi, Catarina Teixeira, Carlos Jared, Olga Martinez Ibañez   +18 more
doaj   +2 more sources

Emerging Role of TRP Channels in Osteoarthritis Pathogenesis [PDF]

Cells
Osteoarthritis (OA) is a degenerative joint disease characterized by cartilage degradation, synovial inflammation, osteophyte formation, joint space narrowing, and persistent pain.
Shivmurat Yadav, Jyoti Yadav, Mary Beth Humphrey   +2 more
doaj   +2 more sources

IFNγ production during cell interactions distinguishes localized from diffuse pigmented villonodular synovitis and rheumatoid arthritis [PDF]

Arthritis Research & Therapy
Background Pigmented villonodular synovitis (PVNS) is a rare articular disease characterized by aggressive synovial proliferation, with localized or diffuse forms.
Mélissa Noack, Pierre Miossec
doaj   +2 more sources

Acid-sensing ion channel 3 decreases phosphorylation of extracellular signal-regulated kinases and induces synoviocyte cell death by increasing intracellular calcium. [PDF]

, 2014
IntroductionAcid-sensing ion channel 3 (ASIC3) is expressed in synoviocytes, activated by decreases in pH, and reduces inflammation in animal models of inflammatory arthritis.
Boyle, David L, Firestein, Gary S, Gong, Weiyi, Kolker, Sandra J, Sluka, Kathleen A, Usachev, Yuriy, Walder, Roxanne Y   +6 more
core   +4 more sources

A Matrigel-Free 3D Chondrocytic Spheroid Model for Rheumatoid Arthritis-Associated Synoviocytes Invasion Studies [PDF]

Journal of Inflammation Research
Yingjie Zhao,1,2,* Xuezhi Yang,3,* Feng Yao,1,2,* Ziwei Ouyang,2 Weirong Hu,2 Lin Li,4 Juan Cheng,5 Ke Wang,1,2 Jie Ding,2 Liang Zheng,1,2 Biao Qu,1,2 Cheng Sun,2 Shufang Li,1 Chen Jiang,2 Yanan Chen,2 Renpeng Zhou,1,2 Wei Hu1,2 1Department ...
Zhao Y, Yang X, Yao F, Ouyang Z, Hu W, Li L, Cheng J, Wang K, Ding J, Zheng L, Qu B, Sun C, Li S, Jiang C, Chen Y, Zhou R, Hu W   +16 more
doaj   +2 more sources

Nanomaterial-Based Drug Delivery Systems Targeting Functional Cells for Osteoarthritis Treatment: Mechanisms, Challenges and Future Prospects [PDF]

International Journal of Nanomedicine
Hui Kong,1,2 Qijun He,2 Juanjuan Han,2 Xin-An Zhang1,2 1College of Exercise and Health, Shanghai University of Sport, Shanghai, People’s Republic of China; 2College of Exercise and Health, Shenyang Sport University, Shenyang, People’s Republic of ...
Kong H, He Q, Han J, Zhang XA
doaj   +2 more sources

The use of animal models in rheumatoid arthritis research [PDF]

Journal of Yeungnam Medical Science, 2023
The pathological hallmark of rheumatoid arthritis (RA) is a synovial pannus that comprises proliferating and invasive fibroblast-like synoviocytes, infiltrating inflammatory cells, and an associated neoangiogenic response.
Jin-Sun Kong, Gi Heon Jeong, Seung-Ah Yoo   +2 more
doaj   +1 more source

Gas Plasma Exposure Attenuates the Inflammatory Rheumatoid Arthritis-Like Phenotype of Murine Synoviocytes in Vitro. [PDF]

J Cell Mol Med
Kordt M, Bergmann-Ewert W, Aleith J, Bekeschus S, Müller-Hilke B.   +4 more
europepmc   +2 more sources

β Boswellic Acid Blocks Articular Innate Immune Responses: An In Silico and In Vitro Approach to Traditional Medicine

Antioxidants, 2023
Osteoarthritis (OA) is hallmarked as a silent progressive rheumatic disease of the whole joint. The accumulation of inflammatory and catabolic factors such as IL6, TNFα, and COX2 drives the OA pathophysiology into cartilage degradation, synovia ...
Eloi Franco-Trepat, Ana Alonso-Pérez, María Guillán-Fresco, Miriam López-Fagúndez, Andrés Pazos-Pérez, Antía Crespo-Golmar, Susana Belén Bravo, Verónica López-López, Alberto Jorge-Mora, José P. Cerón-Carrasco, Ana Lois Iglesias, Rodolfo Gómez   +11 more
doaj   +1 more source

Killing arthritogenic fibroblast-like synoviocytes: an example using cytotoxic aptamers binding nucleolin. [PDF]

Arthritis Res Ther
Kalliolias GD, Basdra EK, Papavassiliou AG.   +2 more
europepmc   +3 more sources