Results 21 to 30 of about 19,285 (227)

Production and Secretion of Gelsolin by Both Human Macrophage- and Fibroblast-like Synoviocytes and GSN Modulation in the Synovial Fluid of Patients with Various Forms of Arthritis

Biomedicines, 2022
Gelsolin (GSN) is an actin-binding protein involved in cell formation, metabolism and wound closure processes. Since this protein is known to play a role in arthritis, here we investigate how the synovial membrane with its specific synoviocytes ...
Jessica Feldt, Martin Schicht, Jessica Welss, Kolja Gelse, Stefan Sesselmann, Michael Tsokos, Eileen Socher, Fabian Garreis, Thomas Müller, Friedrich Paulsen   +9 more
doaj   +1 more source

Metabolic‐Redox Remodeling of Inflammatory Synovium by Mannose‐Modified Selenium Nanoparticles for Osteoarthritis Therapy [PDF]

Advanced science
Elevated GLUT1‐driven glycolysis and disrupted selenoprotein‐dependent redox homeostasis drive osteoarthritic progression. Intra‐articular mannose‐modified selenium nanoparticles (M‐SeNPs) selectively target hypermetabolic synovial cells to reprogram aberrant glycolysis and restore endogenous antioxidant defenses.
Zou Y, Xu C, Li B, Chan L, Xu Y, Su H, Peng R, Luo F, Peng Y, Li Z, Wong V, Zheng X, Ma X, Zha Z, Chen T, Zhang H.   +15 more
europepmc   +2 more sources

Influence of Periostin on Synoviocytes in Knee Osteoarthritis [PDF]

In Vivo, 2017
Periostin (POSTN) is a protein that binds to integrins to support adhesion and migration of epithelial cells. Mice lacking this gene exhibit cardiac valve disease as well as skeletal and dental defects. Recent studies indicated that periostin is involved in the pathogenesis and progression of knee osteoarthritis (OA).
Yutaro, Tajika, Tatsuya, Moue, Shintaro, Ishikawa, Kazuhito, Asano, Takayuki, Okumo, Hiroshi, Takagi, Tadashi, Hisamitsu   +6 more
openaire   +2 more sources

cAMP attenuates TGF-β’s profibrotic responses in osteoarthritic synoviocytes: involvement of hyaluronan and PRG4 [PDF]

, 2018
Osteoarthritis (OA) is characterized by synovitis and synovial fibrosis. Synoviocytes are fibroblast-like resident cells of the synovium that are activated by transforming growth factor (TGF)-β to proliferate, migrate, and produce extracellular matrix ...
Zhang, Ling X., Qadri, Marwa, Ling X. Zhang, Elsaid, Khaled A., Ostrom, Rennolds S., Khaled A. Elsaid, Marwa M. Qadri, Jay, Gregory D., Gregory D. Jay, Rennolds S. Ostrom   +9 more
core   +1 more source

Monoclonal expansion of synoviocytes in rheumatoid arthritis [PDF]

Arthritis & Rheumatism, 1998
To examine whether synoviocytes from patients with rheumatoid arthritis (RA) have a stronger growth ability than those from patients with osteoarthritis (OA), and to determine whether these synoviocytes clonally expand in situ.Synovial tissues from 13 RA patients and 4 OA patients were cultured, and their ability to form colonies in soft agarose was ...
F, Imamura, H, Aono, T, Hasunuma, T, Sumida, H, Tateishi, S, Maruo, K, Nishioka   +6 more
openaire   +2 more sources

Expression of interleukin-18 receptor in fibroblast-like synoviocytes [PDF]

, 2001
An excess of the proinflammatory substance IL-18 is present in joints of patients with rheumatoid arthritis (RA), and expression of IL-18 receptor (IL-18R) regulates IL-18 bioactivity in various cell types.
Hoelzer, Dieter (Prof. Dr.), Rehart, Stefan, Kalina, Uwe, Kessler, Uta, Kukoc-Zivojnov, Natasa, Kaltwasser, Joachim Peter (Prof. Dr.), Ottmann, Oliver G., Möller, Burkhard, Uta Kessler, Oliver G Ottmann, Burkhard Möller, Natasa Kukoc-Zivojnov, Stefan Rehart, Joachim Peter Kaltwasser, Uwe Kalina, Dieter Hoelzer   +15 more
core   +1 more source

Pulsed Electromagnetic Fields: A Novel Attractive Therapeutic Opportunity for Neuroprotection After Acute Cerebral Ischemia

Neuromodulation: Technology at the Neural Interface, EarlyView., 2021
Abstract Objectives Acute cerebral ischemia is characterized by several pathological processes evolving during time, which contribute to the final tissue damage. Secondary processes, such as prolonged inflammatory response, impaired mitochondrial function and oxidative stress, are responsible for the progression of brain injury to the peri‐infarct area,
Fioravante Capone, Simona Salati, Fabrizio Vincenzi, Micaela Liberti, Giorgio Aicardi, Francesca Apollonio, Katia Varani, Ruggero Cadossi, Vincenzo Di Lazzaro   +8 more
wiley   +1 more source

Phenotypic characterization of canine cranial cruciate ligament associated synoviocytes [PDF]

, 2008
Identification of synoviocytes surrounding the canine cranial cruciate ligament (CrCL) has not been investigated. Objectives 1) Develop and validate a technique to identify and quantify normal canine CrCL associated synoviocytes.
Vasanjee, Sunil C., null null, Sunil Vasanjee   +2 more
core   +1 more source

Reduction of expression of IL‐18, IL‐1β genes in the articular joint by sumac fruit extract (Rhus coriaria L.)

Molecular Genetics & Genomic Medicine, 2019
Background Osteoarthritis is the most common malignant disease in the world. The disease is caused by changes in the metabolism, the structure and function of multiple joints, and joint tissues.
Amin Momeni, Hossein Maghsoodi, Sadegh Rezapour, Mostafa Shiravand, Mahnaz Mardani   +4 more
doaj   +1 more source

Effects of pro-inflammatory cytokines and cell interactions on cell area and cytoskeleton of rheumatoid arthritis synoviocytes and immune cells

European Journal of Cell Biology, 2023
Rheumatoid synovitis is infiltrated by immune cells that interact with synoviocytes, leading to the pannus formation. Inflammation or cell interaction effects are mainly evaluated with cytokine production, cell proliferation or migration.
Samira Filali, Mélissa Noack, Alain Géloën, Fabrice Pirot, Pierre Miossec   +4 more
doaj   +1 more source