Results 31 to 40 of about 19,285 (227)

Insulin Exacerbates Inflammation in Fibroblast-Like Synoviocytes [PDF]

Inflammation, 2020
Abstract Osteoarthritis (OA) is considered the most frequent degenerative disease and is characterized by cartilage degradation and synovial inflammation. Fibroblast-like synoviocytes (FLSs) are vital to synovial inflammation in OA. Type 2 diabetes mellitus (T2DM) is characterized by insulin resistance and hyperinsulinemia (HINS) and has been ...
Li Qiao, Yi Li, Shui Sun
openaire   +2 more sources

Synoviocytes from pigmented villonodular synovitis are less sensitive to cadmium-induced cell death than synoviocytes from rheumatoid arthritis

Scientific Reports, 2022
Pigmented villonodular synovitis (PVNS) is a rare inflammatory articular disease sharing common characteristics with rheumatoid arthritis (RA), notably hyperplasia of the synovium due to a hyperproliferation of synoviocytes, and with cancer owing to ...
Héléna Farese, Mélissa Noack, Pierre Miossec   +2 more
doaj   +1 more source

Approaches to enhancing the retroviral transduction of human synoviocytes [PDF]

Arthritis Research & Therapy, 2001
This report concerns a clinical trial for rheumatoid arthritis (RA), approved by the US National Institutes of Health and the Food and Drug Administration. An amphotropic retrovirus (MFG-IRAP) was used ex vivo to transfer a cDNA encoding human interleukin-1 receptor antagonist (IL-1Ra) to synovium.
M A, Del Vecchio, H I, Georgescu, J E, McCormack, P D, Robbins, C H, Evans   +4 more
openaire   +2 more sources

Advancing Early Detection of Osteoarthritis Through Biomarker Profiling and Predictive Modelling: A Review

Biologics
Osteoarthritis (OA) is a multifactorial chronic musculoskeletal disorder characterised by cartilage degradation, synovial inflammation, and subchondral bone remodelling. Conventional diagnostic modalities, including radiographic imaging and symptom-based
Laura Jane Coleman, John L. Byrne, Stuart Edwards, Rosemary O’Hara   +3 more
doaj   +1 more source

Synoviocytes protect cartilage from the effects of injury in vitro [PDF]

, 2013
Background It is well documented that osteoarthritis (OA) can develop following traumatic joint injury and is the leading cause of lameness and subsequent wastage of equine athletes. Although much research of injury induced OA has focused on cartilage,
Frisbie, David D., McIlwraith, C. Wayne, C Wayne McIlwraith, John D Kisiday, David D Frisbie, Lee, Christina M., Kisiday, John D., Grodzinsky, Alan J., Christina M Lee, Alan J Grodzinsky   +9 more
core   +2 more sources

Analyse de l’hyperplasie des synoviocytes et de l’infiltration des cellules immunitaires dans la synovie des patients atteints d’arthrite idiopathique juvénile

, 2021
Analyse de l’hyperplasie des synoviocytes et de l’infiltration des cellules immunitaires dans la synovie des patients atteints d’arthrite idiopathique ...
Triaille, Clément, Boulanger, Cécile, T. Sokolova, C. Galant, C. Boulanger, P. Durez, A. Nzeusseu, B. Lauwerys, C. Triaille, L. Méric de Bellefon, N. Limaye   +10 more
core   +1 more source

Biodiversity-Driven Screening of Amphibian Skin Secretions for Inflammatory Modulation in Joint Diseases

Toxins
This study explores the direct effects of amphibian skin secretions on human cells involved in joint diseases, aiming to identify species with potential for inflammatory modulation.
Douglas Souza Oliveira, César Alexandre, Miryam Paola Alvarez-Flores, Isadora Maria Villas-Boas, Hugo Vigerelli, Isabel de Fátima Correia Batista, Michelle Cristiane Bufalo, Nancy Starobinas, Flávio Lichtenstein, Rafael Marques-Porto, Marcus Buri, Viviane Portas-Lopes, Pedro Luiz Mailho-Fontana, Marta Maria Antoniazzi, Denise Vilarinho Tambourgi, Ana Marisa Chudzinski-Tavassi, Catarina Teixeira, Carlos Jared, Olga Martinez Ibañez   +18 more
doaj   +1 more source

Regulatory T cells provide chondroprotection through increased TIMP1, IL-10 and IL-4, but cannot mitigate the catabolic effects of IL-1β and IL-6 in a tri-culture model of osteoarthritis

Osteoarthritis and Cartilage Open, 2021
Objective: To gain insight into Treg interactions with synovial tissues in early OA, an equine tri-culture model of OA was used to test the hypothesis that Tregs, in the absence of T Helper 17 ​cells, are sufficient to resolve inflammation elicited by IL-
Laura E. Keller, Elia D. Tait Wojno, Laila Begum, Lisa A. Fortier   +3 more
doaj   +1 more source

Angiopoietin-Like Protein 2 Induces Synovial Inflammation in the Facet Joint Leading to Degenerative Changes via Interleukin-6 Secretion [PDF]

Asian Spine Journal, 2019
Study Design Experimental human study. Purpose To determine whether angiopoietin-like protein 2 (ANGPTL2) is highly expressed in the hyperplastic facet joint (FJ) synovium and whether it activates interleukin-6 (IL-6) secretion in FJ synoviocytes ...
Kazuki Sugimoto, Takayuki Nakamura, Takuya Tokunaga, Yusuke Uehara, Tatsuya Okada, Takuya Taniwaki, Toru Fujimoto, Yuichi Oike, Eiichi Nakamura   +8 more
doaj   +1 more source

Systems-biology analysis of rheumatoid arthritis fibroblast-like synoviocytes implicates cell line-specific transcription factor function

Nature Communications, 2022
Fibroblast-like synoviocytes (FLS) are used as a model of rheumatoid arthritis synoviocytes, although cell lines derived from individual patients can have heterogeneous biology.
Richard I. Ainsworth, Deepa Hammaker, Gyrid Nygaard, Cecilia Ansalone, Camilla Machado, Kai Zhang, Lina Zheng, Lucy Carrillo, Andre Wildberg, Amanda Kuhs, Mattias N. D. Svensson, David L. Boyle, Gary S. Firestein, Wei Wang   +13 more
doaj   +1 more source