Results 11 to 20 of about 19,285 (227)
Fibrochondrogenic potential of synoviocytes from osteoarthritic and normal joints cultured as tensioned bioscaffolds for meniscal tissue engineering in dogs [PDF]
PeerJ, 2014 Meniscal tears are a common cause of stifle lameness in dogs. Use of autologous synoviocytes from the affected stifle is an attractive cell source for tissue engineering replacement fibrocartilage. However, the diseased state of these cells may impede in
Jennifer J. Warnock +2 more
doaj +4 more sources
Synoviocyte cultures from synovial fluid
Reumatismo, 2011 The study of the pathogenetic mechanisms of rheumatic diseases is in general carried out through “in vitro” systems based on cellular cultures models.
L. Punzi +7 more
doaj +6 more sources
Epigenetic analysis in rheumatoid arthritis synoviocytes
Experimental & Molecular Medicine, 2019 Rheumatoid arthritis (RA) is a complex chronic systematic disease with progressive destruction of the joints by invasive synoviocytes. To characterize the key regulators involved in the development of RA, we obtained multilayer epigenomics data including DNA methylation by whole-genome bisulfite sequencing, miRNA profiles, genetic variations by whole ...
Seokjin Ham +6 more
openaire +5 more sources
Filoviruses Infect Rhesus Macaque Synoviocytes in Vivo and Primary Human Synoviocytes in Vitro [PDF]
The American Journal of Pathology, 2020 The most commonly reported symptom of post-Ebola virus disease syndrome in survivors is arthralgia, yet involvement of the joints in acute or convalescent Ebola virus infection is not well characterized in human patients or animal models. Through immunohistochemistry, we found that the lining synovial intima of the stifle (knee) is a target for acute ...
Timothy K. Cooper +15 more
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Hyaluronan secretion by synoviocytes is mechanosensitive [PDF]
Matrix Biology, 2005 Hyaluronan (HA) is an essential component of synovial interstitial matrix and synovial fluid, but the link between its production and joint use is unclear. HA secretion is enhanced by joint distension in vivo, but direct proof that synoviocytes exhibit mechanosensitive HA secretion is lacking. We tested this in vitro.
T S, Momberger, J R, Levick, R M, Mason
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Potential role ofHOXD9 in synoviocyte proliferation [PDF]
Arthritis & Rheumatism, 2001 To investigate the role of HOXD9 in the proliferation activity of cultured synoviocytes as well as the mechanisms that regulate HOXD9 transcription.Synoviocytes from patients with rheumatoid arthritis (RA) and osteoarthritis (OA) were transfected with HOXD9 complementary DNA to establish stable transformants that overexpressed HOXD9.
N D, Khoa +6 more
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Antioxidants, 2023 Osteoarthritis (OA) is hallmarked as a silent progressive rheumatic disease of the whole joint. The accumulation of inflammatory and catabolic factors such as IL6, TNFα, and COX2 drives the OA pathophysiology into cartilage degradation, synovia ...
Eloi Franco-Trepat +11 more
doaj +1 more source
Targeting fibroblast-like synoviocytes in rheumatoid arthritis [PDF]
Current Opinion in Pharmacology, 2022 Fibroblast-like synoviocytes (FLS) are mesenchymal-derived cells that play an important role in the physiology of the synovium by producing certain components of the synovial fluid and articular cartilage. In rheumatoid arthritis (RA), however, fibroblasts become a key driver of synovial inflammation and joint damage.
Vladislav Tsaltskan, Gary S. Firestein
openaire +3 more sources
Exogenous stromal cell-derived factor-1 (SDF-1) suppresses the NLRP3 inflammasome and inhibits pyroptosis in synoviocytes from osteoarthritic joints via activation of the AMPK signaling pathway [PDF]
, 2021 Objective: NLRP3 inflammasome may play a key role in OA pathogenesis. Stromal cell-derived factor-1 (SDF-1) is a homeostatic CXC chemokine. Since the role of SDF-1 in OA has not been explored, this study aimed to examine the effect of SDF-1 on NLRP3 ...
Wang, Yanli +11 more
core +1 more source
CD147 overexpression on synoviocytes in rheumatoid arthritis enhances matrix metalloproteinase production and invasiveness of synoviocytes [PDF]
Arthritis Research & Therapy, 2006 AbstractMacrophage-like synoviocytes and fibroblast-like synoviocytes (FLS) are known as the most active cells of rheumatoid arthritis (RA) and are close to the articular cartilage in a position enabling them to invade the cartilage. Macrophage-like synoviocytes and FLS expression of matrix metalloproteinases (MMPs) and their interaction has aroused ...
Zhu, Ping +7 more
openaire +2 more sources