Results 11 to 20 of about 30,224 (276)
Synoviocyte cultures from synovial fluid
Reumatismo, 2011 The study of the pathogenetic mechanisms of rheumatic diseases is in general carried out through “in vitro” systems based on cellular cultures models.
L. Punzi +7 more
doaj +6 more sources
Scientific Reports, 2022 Pigmented villonodular synovitis (PVNS) is a rare inflammatory articular disease sharing common characteristics with rheumatoid arthritis (RA), notably hyperplasia of the synovium due to a hyperproliferation of synoviocytes, and with cancer owing to ...
Héléna Farese +2 more
doaj +3 more sources
Filoviruses Infect Rhesus Macaque Synoviocytes in Vivo and Primary Human Synoviocytes in Vitro [PDF]
The American Journal of Pathology, 2020 The most commonly reported symptom of post-Ebola virus disease syndrome in survivors is arthralgia, yet involvement of the joints in acute or convalescent Ebola virus infection is not well characterized in human patients or animal models. Through immunohistochemistry, we found that the lining synovial intima of the stifle (knee) is a target for acute ...
Timothy K. Cooper +15 more
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Targeting fibroblast-like synoviocytes in rheumatoid arthritis [PDF]
Current Opinion in Pharmacology, 2022 Fibroblast-like synoviocytes (FLS) are mesenchymal-derived cells that play an important role in the physiology of the synovium by producing certain components of the synovial fluid and articular cartilage. In rheumatoid arthritis (RA), however, fibroblasts become a key driver of synovial inflammation and joint damage.
Vladislav Tsaltskan, Gary S. Firestein
openaire +3 more sources
Frontiers in Immunology, 2022 We have recently provided new evidence for a role of p75NTR receptor and its preferential ligand proNGF in amplifying inflammatory responses in synovial mononuclear cells of chronic arthritis patients.
Luciapia Farina +18 more
doaj +1 more source
Bone & Joint Research, 2021 Rheumatoid arthritis (RA) is an autoimmune disease characterized by symmetrical and chronic polyarthritis. Fibroblast-like synoviocytes are mainly involved in joint inflammation and cartilage and bone destruction by inflammatory cytokines and matrix ...
Minjeong Ji +2 more
doaj +1 more source
Pharmaceutics, 2021 Osteoarthritis (OA) is a complex multi-target disease with an unmet medical need for the development of therapies that slow and potentially revert disease progression.
Carlota Salgado +2 more
doaj +1 more source
Potential role ofHOXD9 in synoviocyte proliferation [PDF]
Arthritis & Rheumatism, 2001 To investigate the role of HOXD9 in the proliferation activity of cultured synoviocytes as well as the mechanisms that regulate HOXD9 transcription.Synoviocytes from patients with rheumatoid arthritis (RA) and osteoarthritis (OA) were transfected with HOXD9 complementary DNA to establish stable transformants that overexpressed HOXD9.
N D, Khoa +6 more
openaire +2 more sources
Biomedicines, 2022 Gelsolin (GSN) is an actin-binding protein involved in cell formation, metabolism and wound closure processes. Since this protein is known to play a role in arthritis, here we investigate how the synovial membrane with its specific synoviocytes ...
Jessica Feldt +9 more
doaj +1 more source
Neuromodulation: Technology at the Neural Interface, EarlyView., 2021 Abstract Objectives Acute cerebral ischemia is characterized by several pathological processes evolving during time, which contribute to the final tissue damage. Secondary processes, such as prolonged inflammatory response, impaired mitochondrial function and oxidative stress, are responsible for the progression of brain injury to the peri‐infarct area,
Fioravante Capone +8 more
wiley +1 more source