Results 41 to 50 of about 19,285 (227)
Simvastatin Induces Apoptosis of Fibroblast-Like Synoviocytes [PDF]
The Open Rheumatology Journal, 2009 Background: Statins (3-Hydroxy-3-methylglutaryl-CoA reductase inhibitors) exert favorable effects on lipoprotein metabolism, but appeared to possess anti-inflammatory properties among others, as suggested by their ability to inhibit collagen-induced arthritis in mice.
Litinsky, Ira +5 more
openaire +2 more sources
SW982 synoviocytes express a variety of PLA2 enzymes.
, 2015 Transcriptional expression of PLA2 enzymes in placenta and unstimulated synoviocytes was determined by qPCR as described in the Methods section. PCR product specificity from placenta (A) and synoviocytes (B) were analyzed by gel electrophoresis according
Trine Skuland (727414) +3 more
core +1 more source
Angiotensin II protects fibroblast-like synoviocytes from apoptosis via the AT1-NF-kappaB pathway [PDF]
, 2007 To evaluate the effects of angiotensin II (Ang II) treatment on apoptosis of fibroblast-like synoviocytes (FLS) from patients with osteoarthritis (OA) and rheumatoid arthritis (RA)
Albertazzi, L +11 more
core +1 more source
Regulation of DNA Methylation in Rheumatoid Arthritis Synoviocytes [PDF]
The Journal of Immunology, 2013 Abstract Rheumatoid arthritis (RA) is a chronic inflammatory disease in which fibroblast-like synoviocytes (FLS) exhibit an aggressive phenotype. Although the mechanisms responsible are not well defined, epigenetic determinants such as DNA methylation might contribute. DNA methyltransferases (DNMTs) are critical enzymes that establish
Kazuhisa, Nakano +2 more
openaire +2 more sources
Additional file 4: of Monosodium urate crystals induce oxidative stress in human synoviocytes
, 2016 UGDH gene expression and CD14 in synoviocytes. Synoviocytes characterized by qRT-PCR. Each bar shows the average ± standard deviation of three independent experiments from different patients (n = 5); *P
Jorge Cerna-Cortés (3503957) +15 more
core +1 more source
Frontiers in Immunology, 2017 The production and function of cytokines are highly regulated. One mechanism is the balance between pro- and anti-inflammatory cytokines. As interleukin (IL)-17A and IL-25 share the IL-17RA receptor chain, we hypothesize that IL-25 acts as an IL-17A ...
Fabien Lavocat +2 more
doaj +1 more source
Advanced Science, EarlyView.AI‑guided single‑cell transcriptomics identifies OGT as a key regulator enriched in rheumatoid arthritis fibroblast‑like synoviocytes (RA‐FLSs). Inflammatory stimuli activate the OGT–SAP130 axis, which modulates the H3K27ac/H3K27me3 balance and epigenetically silences BTG2, promoting aggressive transformation of RA‑FLSs.
Duoli Xie +14 more
wiley +1 more source
Morphology and Functional Roles of Synoviocytes in the Joint.
Archives of Histology and Cytology, 2000 The joint capsule exhibits a unique cellular lining in the luminal surface of the synovial membrane. The synovial intimal cells, termed synoviocytes, are believed to be responsible for the production of synovial fluid components, for absorption from the joint cavity, and for blood/synovial fluid exchanges, but their detailed structure and function as ...
IWANAGA, Toshihiko +4 more
openaire +3 more sources
Th17 and Th1 Lymphocytes in Oligoarticular Juvenile Idiopathic Arthritis
Frontiers in Immunology, 2019 In the last years much attention has focused on the Th17 and Th1 phenotypes and on their pathogenic role in juvenile idiopathic arthritis, investigating how the cytokines produced by T helper cells act on resident cells on the synovia and which signal ...
Laura Maggi +5 more
doaj +1 more source
Bioenergetic Materials for Tissue Regeneration: Modulating Metabolism to Promote Cellular Anabolism
Advanced Science, EarlyView.Bioenergetic materials (BEMs) modulate cellular metabolism to promote tissue regeneration. Their principal mechanisms of action include metabolic substrate supplementation, metabolic enzyme modulation, organelle transfer, electrical current regulation, redox homeostasis modulation, and oxygen tension modulation.
Yuchen He +7 more
wiley +1 more source