Results 41 to 50 of about 30,224 (276)

Epigenetic analysis in rheumatoid arthritis synoviocytes

Experimental & Molecular Medicine, 2019
Rheumatoid arthritis (RA) is a complex chronic systematic disease with progressive destruction of the joints by invasive synoviocytes. To characterize the key regulators involved in the development of RA, we obtained multilayer epigenomics data including DNA methylation by whole-genome bisulfite sequencing, miRNA profiles, genetic variations by whole ...
Seokjin Ham, Jae-Bum Bae, Suman Lee, Bong-Jo Kim, Bok-Ghee Han, Seung-Ki Kwok, Tae-Young Roh   +6 more
openaire   +4 more sources

Systems-biology analysis of rheumatoid arthritis fibroblast-like synoviocytes implicates cell line-specific transcription factor function

Nature Communications, 2022
Fibroblast-like synoviocytes (FLS) are used as a model of rheumatoid arthritis synoviocytes, although cell lines derived from individual patients can have heterogeneous biology.
Richard I. Ainsworth, Deepa Hammaker, Gyrid Nygaard, Cecilia Ansalone, Camilla Machado, Kai Zhang, Lina Zheng, Lucy Carrillo, Andre Wildberg, Amanda Kuhs, Mattias N. D. Svensson, David L. Boyle, Gary S. Firestein, Wei Wang   +13 more
doaj   +1 more source

Management of Osteoarthritis with Avocado/Soybean Unsaponifiables. [PDF]

, 2015
Osteoarthritis (OA) is a painful and life-altering disease that severely limits the daily activity of millions of Americans, and is one of the most common causes of disability in the world. With obesity on the rise and the worlds population living longer,
Bhatti, Simi, Christiansen, Blaine, Emami, Shahin, Goudarzi, Ramin   +3 more
core   +1 more source

Expression of interleukin-18 receptor in fibroblast-like synoviocytes [PDF]

, 2001
An excess of the proinflammatory substance IL-18 is present in joints of patients with rheumatoid arthritis (RA), and expression of IL-18 receptor (IL-18R) regulates IL-18 bioactivity in various cell types.
Möller, Burkhard, Kessler, Uta, Rehart, Stefan, Kalina, Uwe, Ottmann, Oliver G., Kaltwasser, Joachim Peter (Prof. Dr.), Hoelzer, Dieter (Prof. Dr.), Kukoc-Zivojnov, Natasa   +7 more
core   +1 more source

Interactive Cytokine Regulation of Synoviocyte Lubricant Secretion [PDF]

Tissue Engineering Part A, 2010
Cytokine regulation of synovial fluid (SF) lubricants, hyaluronan (HA), and proteoglycan 4 (PRG4) is important in health, injury, and disease of synovial joints, and may also provide powerful regulation of lubricant secretion in bioreactors for articulating tissues.
Megan E, Blewis, Brian J, Lao, Barbara L, Schumacher, William D, Bugbee, Robert L, Sah, Gary S, Firestein   +5 more
openaire   +2 more sources

Advancing Early Detection of Osteoarthritis Through Biomarker Profiling and Predictive Modelling: A Review

Biologics
Osteoarthritis (OA) is a multifactorial chronic musculoskeletal disorder characterised by cartilage degradation, synovial inflammation, and subchondral bone remodelling. Conventional diagnostic modalities, including radiographic imaging and symptom-based
Laura Jane Coleman, John L. Byrne, Stuart Edwards, Rosemary O’Hara   +3 more
doaj   +1 more source

SIRT1 is transcriptionally repressed by YY1 and suppresses ferroptosis in rheumatoid arthritis

Advances in Rheumatology, 2023
Highlights 1. Combining SIRT1 with synoviocytes ferroptosis in rheumatoid arthritis for the first time. 2. The transcription factor YY1 combined to the SIRT1 promoter in synovial cells and inhibited its expression and functional roles. 3.
Yuwei Zhan, Zhou Yang, Feng Zhan, Yanyan Huang, Shudian Lin   +4 more
doaj   +1 more source

Brucella and Osteoarticular Cell Activation: Partners in Crime [PDF]

, 2017
Osteoarticular brucellosis is the most common presentation of human active disease although its prevalence varies widely. The three most common forms of osteoarticular involvement are sacroiliitis, spondylitis, and peripheral arthritis.
Adamopoulos, Adarichev, Al-Eissa, Aydin, Azuma, Bartok, Behera, Bivi, Bonewald, Burrage, Buzgan, Cenci, Chen, Civitelli, Colmenero, Delpino, Delpino, Delpino, D’Amelio, D’Amelio, El-Jawhari, Farkas, Fuller, Garcia Samartino, Geiger, Giambartolomei, Giambartolomei, Gilmore, Goenka, Goenka, Golding, Gotuzzo, Grundt, Haynes, Horowitz, Ibero, Ikeda, Inman, Karner, Kasim, Kawai, Kitazawa, Kobayashi, Kollet, Kong, Kotake, Lacey, Lampiasi, Lerner, Madkour, Madkour, Magnani, Merkel, Milner, Mori, Nair, Nakayamada, Pappas, Pappas, Pesce Viglietti, Press, Prideaux, Rajapakse, Rajashekara, Rodan, Roggia, Sato, Scian, Scian, Scian, Scian, Shaalan, Skyberg, Soder, Song, Streuli, Takayanagi, Takayanagi, Takayanagi, Tanaka, Teitelbaum, Thomson, Tokoyoda, Turan, Viau, Visnjic, Wallach, Wei, Yasuda, Young, Young, Zhan, Zhan, Zhan, Zhao, Zwerdling   +95 more
core   +1 more source

Interleukin-25 Produced by Synoviocytes Has Anti-inflammatory Effects by Acting As a Receptor Antagonist for Interleukin-17A Function

Frontiers in Immunology, 2017
The production and function of cytokines are highly regulated. One mechanism is the balance between pro- and anti-inflammatory cytokines. As interleukin (IL)-17A and IL-25 share the IL-17RA receptor chain, we hypothesize that IL-25 acts as an IL-17A ...
Fabien Lavocat, Ndiémé Ndongo-Thiam, Pierre Miossec   +2 more
doaj   +1 more source

Hypomethylation of CYP2E1 and DUSP22 Promoters Associated With Disease Activity and Erosive Disease Among Rheumatoid Arthritis Patients. [PDF]

, 2018
OBJECTIVE:Epigenetic modifications have previously been associated with rheumatoid arthritis (RA). In this study, we aimed to determine whether differential DNA methylation in peripheral blood cell subpopulations is associated with any of 4 clinical ...
Barcellos, Lisa F, Chernitskiy, Vladimir, Criswell, Lindsey A, Graf, Jonathan, Harrison, Ruby, Holingue, Calliope, Imboden, John, Link, Thomas, Mok, Amanda, Quach, Diana, Quach, Hong L, Rhead, Brooke, Shao, Xiaorong, Sinclair, Elizabeth   +13 more
core   +1 more source