Results 51 to 60 of about 30,224 (276)

Epigenetic Alterations in Rheumatoid Arthritis Fibroblast-Like Synoviocytes [PDF]

Epigenomics, 2017
Rheumatoid arthritis is an immune-mediated disease that primarily affects diarthrodial joints. Susceptibility and severity of this disease are influenced by nongenetic factors, such as environmental stress, suggesting an important role of epigenetic changes.
Doody, Karen M, Bottini, Nunzio, Firestein, Gary S   +2 more
openaire   +4 more sources

Th17 and Th1 Lymphocytes in Oligoarticular Juvenile Idiopathic Arthritis

Frontiers in Immunology, 2019
In the last years much attention has focused on the Th17 and Th1 phenotypes and on their pathogenic role in juvenile idiopathic arthritis, investigating how the cytokines produced by T helper cells act on resident cells on the synovia and which signal ...
Laura Maggi, Alessio Mazzoni, Rolando Cimaz, Francesco Liotta, Francesco Annunziato, Lorenzo Cosmi   +5 more
doaj   +1 more source

Bacterial Infection Elicits Heat Shock Protein 72 Release from Pleural Mesothelial Cells [PDF]

, 2013
Heat shock protein 70 (HSP70) has been implicated in infection-related processes and has been found in body fluids during infection. This study aimed to determine whether pleural mesothelial cells release HSP70 in response to bacterial infection in vitro
Bielsa, S, Brown, JS, Creaney, J, della Vergiliana, JFV, Lansley, SM, Lee, YCG, Porcel, JM, Temple, SEL, Waterer, GW   +8 more
core   +1 more source

Synoviocytes and skin fibroblasts show opposite effects on IL-23 production and IL-23 receptor expression during cell interactions with immune cells

Arthritis Research & Therapy, 2022
Background The IL-23/IL-17 axis is involved in inflammatory diseases including arthritis and psoriasis. However, the response to IL-23 or IL-17 inhibitors is different depending on the disease.
Mélissa Noack, Pierre Miossec
doaj   +1 more source

Altered phospholipids in human rheumatoid synoviocytes. [PDF]

Annals of the Rheumatic Diseases, 1978
A specific cytochemical reaction for freely available phospholipids has shown a raised concentration of such phospholipids in the lining cells of human synovial membranes removed from rheumatoid joints. Quantitative measurement, by microdensitometry, of the amount of reaction-product per cell showed that the rheumatoid synoviocytes contained almost ...
B, Henderson, L, Bitensky, J, Chayen
openaire   +2 more sources

An overview of carbonic anhydrases and membrane channels of synoviocytes in inflamed joints

Journal of Enzyme Inhibition and Medicinal Chemistry, 2019
The highly aggressive fibroblast-like synoviocytes (FLSs) are inflammatory mediators involved in synovial joint destruction. Membrane channels and transporters are essential components of the cell migration apparatus and are involved in various cellular ...
Min Jeong Ji, Jeong Hee Hong
doaj   +1 more source

Synthesis and bioactivity of a conjugate composed of green tea catechins and hyaluronic acid [PDF]

, 2015
(-)-Epigallocatechin-3-gallate (EGCG) is a green tea polyphenol that has several biological activities, including anti-cancer activity and anti-inflammation.
Chung, Joo Eun, Hauser, Charlotte A. E., Hauser, Charlotte A.E., Kurisawa, Motoichi, Lee, Fan, Lee, Su Seong, Lim, Jaehong, Reithofer, Michael R.   +7 more
core   +1 more source

Pyroptosis for osteoarthritis treatment: insights into cellular and molecular interactions inflammatory

Frontiers in Immunology
Osteoarthritis (OA) is a widely prevalent chronic degenerative disease often associated with significant pain and disability. It is characterized by the deterioration of cartilage and the extracellular matrix (ECM), synovial inflammation, and subchondral
Minghui Lin, Cunxin Zhang, Haiming Li, Kang Li, Shuao Gou, Xiao He, Xiao He, Chaoliang Lv, Kai Gao   +8 more
doaj   +1 more source

The autocrine role of proteoglycan-4 (PRG4) in modulating osteoarthritic synoviocyte proliferation and expression of matrix degrading enzymes

Arthritis Research & Therapy, 2017
Background Lubricin/proteoglycan 4 (PRG4) is a mucinous glycoprotein secreted by synovial fibroblasts and superficial zone chondrocytes. Recently, we showed that recombinant human PRG4 (rhPRG4) is a putative ligand for CD44 receptor.
Ali Alquraini, Maha Jamal, Ling Zhang, Tannin Schmidt, Gregory D. Jay, Khaled A. Elsaid   +5 more
doaj   +1 more source

Expression and Localization of aquaporin‐1 in Temporomandibular Joint Disc with Internal Derangement [PDF]

, 2012
Background: Internal derangement is the most frequent arthropathy affecting the temporomandibular joint, where its commonest form is anterior disc displacement with or without reduction.
Almeida, Luis Eduardo, Caltabiano, Rosario, Carnazza, Maria Luisa, Galanti, Concetta, Leonardi, Rosalia, Loreto, Carla, Musumeci, Giuseppe, Pannone, Giuseppe   +7 more
core   +2 more sources