Results 51 to 60 of about 19,285 (227)

SIRT1 is transcriptionally repressed by YY1 and suppresses ferroptosis in rheumatoid arthritis

Advances in Rheumatology, 2023
Highlights 1. Combining SIRT1 with synoviocytes ferroptosis in rheumatoid arthritis for the first time. 2. The transcription factor YY1 combined to the SIRT1 promoter in synovial cells and inhibited its expression and functional roles. 3.
Yuwei Zhan, Zhou Yang, Feng Zhan, Yanyan Huang, Shudian Lin   +4 more
doaj   +1 more source

Influence of IL13 on Periostin Secretion by Synoviocytes in Osteoarthritis [PDF]

In Vivo, 2017
Our previous research provided evidence of periostin increase in parallel with interleukin-13 (IL13) increase in the synovial fluid of patients with osteoarthritis (OA). The reaction cascade from IL13 to periostin, however, remains unidentified. We, therefore, tested the hypothesis that periostin secretion is affected downstream of IL13.OA synoviocytes
Tatsuya, Moue, Yutaro, Tajika, Shintaro, Ishikawa, Yasuaki, Kanada, Takayuki, Okumo, Kazuhito, Asano, Tadashi, Hisamitsu   +6 more
openaire   +2 more sources

Extracellular Vesicle-Derived microRNA Crosstalk Between Equine Chondrocytes and Synoviocytes—An In Vitro Approach [PDF]

This study describes a novel technique to analyze the extracellular vesicle (EV)-derived microRNA (miRNA) crosstalk between equine chondrocytes and synoviocytes. Donor cells (chon- drocytes, n=8; synoviocytes, n=9) were labelled with 5-ethynyl uridine (5-
Clegg, Peter D, Peffers, Mandy J, Clarke, Emily J., Catarina I. G. D. Castanheira, Clegg, Peter D., James, Victoria, Clarke, Emily J, Castanheira, Catarina IGD, Peffers, Mandy J., Matthias Hackl, Peter D. Clegg, Hackl, Matthias, James R. Anderson, Mandy J. Peffers, Anderson, James R., Anderson, James R, Victoria James, Emily J. Clarke, Castanheira, Catarina I. G. D.   +18 more
core   +1 more source

Emerging Role of TRP Channels in Osteoarthritis Pathogenesis

Cells
Osteoarthritis (OA) is a degenerative joint disease characterized by cartilage degradation, synovial inflammation, osteophyte formation, joint space narrowing, and persistent pain.
Shivmurat Yadav, Jyoti Yadav, Mary Beth Humphrey   +2 more
doaj   +1 more source

Optimizing Efficacy to Safety Ratio of Glucocorticoids in Rheumatoid Arthritis Models by Leveraging Peroxisome Proliferator–Activated Nuclear Receptor‐α Agonism

Arthritis &Rheumatology, EarlyView.
Objective Glucocorticoids remain essential therapies for immune and inflammatory diseases such as rheumatoid arthritis (RA) but are notorious for their metabolic side effects. Given the anti‐inflammatory and metabolically favorable actions of peroxisome proliferator–activated nuclear receptor (PPAR) agonists, we investigated whether PPARα agonism could
Lisa L. Koorneef, Elisabeth Gilis, Dorien Clarisse, Daria Fijalkowska, Sara Dufour, Julie Coudeneys, Bert Luyckx, Annick Verhee, Jonathan Thommis, Candice Vanden Bussche, Ulf Müller‐Ladner, Elena Neumann, Matthias Kerkhofs, Guillaume Planckaert, Simon Devos, Leander Meuris, Dirk Elewaut, Karolien De Bosscher   +17 more
wiley   +1 more source

Synoviocytes and skin fibroblasts show opposite effects on IL-23 production and IL-23 receptor expression during cell interactions with immune cells

Arthritis Research & Therapy, 2022
Background The IL-23/IL-17 axis is involved in inflammatory diseases including arthritis and psoriasis. However, the response to IL-23 or IL-17 inhibitors is different depending on the disease.
Mélissa Noack, Pierre Miossec
doaj   +1 more source

Plasma Proteomics Identifies Molecular Signatures and Biomarkers Associated With High Structural Damage in Ankylosing Spondylitis

Arthritis &Rheumatology, EarlyView.
Objective Pathologic bone formation in ankylosing spondylitis (AS) is not fully reflected by systemic inflammation, limiting the utility of markers of inflammation for structural damage assessment. This study aimed to identify plasma protein signatures associated with structural damage severity in AS.
Tiantian Sun, Wanlin Liu, Kun Yang, Xiaohan Xu, Yu Wang, Xinning Qu, Yifan Gong, Wenya Zhang, Jie Ma, Hongxiao Liu   +9 more
wiley   +1 more source

Spatial Proteomics Identifies Distinct Synovial Microenvironments in Hip and Knee Osteoarthritis

Arthritis &Rheumatology, Accepted Article.
Objective Osteoarthritis (OA) is a heterogeneous joint disease, yet mechanistic insights derive predominantly from knee OA and are often extrapolated to other joints. We investigated joint‐associated differences in the spatial molecular organization of hip and knee OA synovium.
Peng Xie, Antonia R. Sun, Zhengtan Zheng, Yunkun Qu, Feng Gao, Christina Theodoropoulos, Nicholas Matigian, Zhiyong Li, Ross Crawford, Indira Prasadam   +9 more
wiley   +1 more source

The synovial proteome: analysis of fibroblast-like synoviocytes [PDF]

Arthritis Res Ther, 2004
The present studies were initiated to determine the protein expression patterns of fibroblast-like synovial (FLS) cells derived from the synovia of rheumatoid arthritis patients. The cellular proteins were separated by two-dimensional polyacrylamide gel electrophoresis and the in-gel digested proteins were analyzed by matrix-assisted laser desorption ...
Dasuri, Kumar, Antonovici, Mihaela, Chen, Keding, Wong, Ken, Standing, Kenneth, Ens, Werner, El-Gabalawy, Hani, Wilkins, John A   +7 more
openaire   +3 more sources

Diagrammatic scheme denoting the cascade of events that fostering folate deficient synoviocytes to apoptosis.

, 2016
Diagrammatic scheme denoting the cascade of events that fostering folate deficient synoviocytes to apoptosis.
Jin-Yi Wu (548836), Hung-Chih Hsu (479317), Ching-Hsein Chen (325864), Kai-Hua Chen (570148), Yi-Wen Chuang (570146), Fung-Jou Lu (89259), Rang-Hui Yeh (846085), Wen-Ming Chang (570147), Chin-Chin Huang (846084), Tsan-Zon Liu (479323), Pey-Jium Chang (479322), Chang-Zern Hong (570149)   +11 more
core   +1 more source