Results 71 to 80 of about 19,285 (227)

Disulfidptosis‐ and Ferroptosis‐Related Gene Signatures in Rheumatoid Arthritis: Association Analysis and Diagnostic Model Construction

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by persistent synovial inflammation and progressive joint damage. Although ferroptosis has been implicated in RA progression, the role of disulfidptosis and its interaction with ferroptosis remains unclear.
Ting‐Ting Wang, Dong‐Mei Wang, Xue Li, Yuan‐Li Wei, Ping‐Dan Liu, Shi‐Lin Li, Si‐Ying Xiong, Cai‐Zhen Liu, Fan‐Xin Zeng, Jian‐Hong Wu, Lin Tang   +10 more
wiley   +1 more source

Exposure to Zn and pro-inflammatory cytokines synergistically affect IL-6 production in RA synoviocytes.

, 2016
OA and RA synoviocytes were treated overnight with IL-17A (50 ng/mL) and TNF-α (0.5 ng/mL) followed by the addition of different Zn concentrations (0.9 and 3.6 ppm). Supernatants were collected at day 1, 5 and 8.
Aline Lamboux (2158294), Paola Bonaventura (2158297), Francis Albarède (184161), Pierre Miossec (3350)   +3 more
core   +1 more source

Natural Products Exhibit Therapeutic Potential in Treating Rheumatoid Arthritis by Targeting the PI3K/Akt Signaling Pathway

Phytotherapy Research, EarlyView.
This review summarizes how natural products, mainly including flavonoids, terpenoids, alkaloids, and polyphenols alleviate RA via PI3K/Akt pathway, regulating inflammation, proliferation, apoptosis, angiogenesis, and osteoclast differentiation. The figure was created by Figdraw (https://www.figdraw.com/#/).
Haishuo Ren, Yige Wang, Wenjing Ma, Omachi Daniel Ogaji, Shujing Chen, Kunze Du, Xuemi Zhang, Bo Xu, Shanxing Zhai, Shiming Fang, Yanxu Chang   +10 more
wiley   +1 more source

MicroRNA-340-5p suppressed rheumatoid arthritis synovial fibroblast proliferation and induces apoptotic cell number by targeting signal transducers and activators of transcription 3

Autoimmunity, 2020
Rheumatoid arthritis is a chronic systemic autoimmune disease. In this study, the role of microRNA-340-5p in rheumatoid arthritis was investigated. qRT-PCR was used to detect the expression of microRNA-340-5p in serums, synovial tissues, and fibroblast ...
Shibin Zhang, Tingting Meng, Chunzhi Tang, Shengdong Li, Xudong Cai, Dawei Wang, Min Chen   +6 more
doaj   +1 more source

Self-assembled peptide-substance P hydrogels alleviate inflammation and ameliorate the cartilage regeneration in knee osteoarthritis

Biomaterials Research, 2023
Background Self-assembled peptide (SAP)-substance P (SP) hydrogels can be retained in the joint cavity longer than SP alone, and they can alleviate inflammation and ameliorate cartilage regeneration in knee osteoarthritis (OA). We conducted a preclinical
Sang Jun Kim, Ji Eun Kim, Goeun Choe, Da Hyun Song, Sun Jeong Kim, Tae Hee Kim, Jin Yoo, Soo Hyun Kim, Youngmee Jung   +8 more
doaj   +1 more source

Optimization of the Isolation and Purification of Formononetin from Lycopus lucidus Turcz. var. hirtus Regel, Structural Identification, and Its In Vitro Anti-Inhibitory Effects in TNF-α-Induced HFLS-RA Cells

Plants
Lycopus lucidus Turcz. var. hirtus Regel (L. lucidus var. hirtus) is a medicinal herb traditionally used in Chinese folk medicine for the treatment of inflammatory disorders, joint pain, and rheumatoid arthritis (RA)-like symptoms.
Feiran Hu, Wenzhao Zhou, Nong Zhou, Lanlan Wan, Linyun Pu, Caiyun Fu, Hua Zhang, Junsheng Qi   +7 more
doaj   +1 more source

Effect on mechanical properties of articular cartilage through inflammatory response of synoviocytes under tissue and cell co-culture model

Nihon Kikai Gakkai ronbunshu, 2014
Articular cartilage has a poor ability to regenerate itself, therefore it is important to establish the treatment methodologies for cartilage diseases such as osteoarthritis (OA) or rheumatoid arthritis (RA).
Shinya YAMAZAKI, Shogo MIYATA
doaj   +1 more source

Differential effects of TNF-α and IL-1β on the control of metal metabolism and cadmium-induced cell death in chronic inflammation. [PDF]

PLoS ONE, 2018
Interleukin-1-beta (IL-1β) and tumour necrosis factor-alpha (TNF-α) are both monocyte-derived cytokines. Both cytokines have been previously described to exert a role in rheumatoid arthritis (RA) pathogenesis synergizing with other pro-inflammatory ...
Paola Bonaventura, Aline Lamboux, Francis Albarède, Pierre Miossec   +3 more
doaj   +1 more source

Natural Polysaccharides for Rheumatoid Arthritis Therapy: Mechanism, Drug Delivery and Clinical Application

Phytotherapy Research, EarlyView.
Schematic overview of the experimental models, therapeutic mechanisms, drug delivery systems, and clinical potential of natural polysaccharides in rheumatoid arthritis. ABSTRACT Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized primarily by chronic synovitis.
Luxin Li, Junnan Li, Guangzhi Li, Lili Huang, Tiantian Wen, Yanying Li, Yan Sun, Zhenqiang Liu, Qingshan Chen, Lili Zhang, Tiangang Lu, Ruiyan Wu, Haixue Kuang, Xiaochi Ma, Yan Liu   +14 more
wiley   +1 more source

Interactive Cytokine Regulation of Synoviocyte Lubricant Secretion [PDF]

Tissue Engineering Part A, 2010
Cytokine regulation of synovial fluid (SF) lubricants, hyaluronan (HA), and proteoglycan 4 (PRG4) is important in health, injury, and disease of synovial joints, and may also provide powerful regulation of lubricant secretion in bioreactors for articulating tissues.
Megan E, Blewis, Brian J, Lao, Barbara L, Schumacher, William D, Bugbee, Robert L, Sah, Gary S, Firestein   +5 more
openaire   +2 more sources