Results 1 to 10 of about 43,674 (271)

Comparison of mesenchymal stem cells obtained by suspended culture of synovium from patients with rheumatoid arthritis and osteoarthritis

BMC Musculoskeletal Disorders, 2018
Background Mobilization of mesenchymal stem cells (MSCs) from the synovium was revealed using a “suspended synovium culture model” of osteoarthritis (OA). The pathology of rheumatoid arthritis (RA) differs from that of OA.
Yuji Kohno, Mitsuru Mizuno, Nobutake Ozeki, Hisako Katano, Koji Otabe, Hideyuki Koga, Mikio Matsumoto, Haruka Kaneko, Yuji Takazawa, Ichiro Sekiya   +9 more
doaj   +2 more sources

Synovial immune control failure in osteoarthritis: from maintenance of tissue homeostasis to inflammatory niche formation [PDF]

Frontiers in Immunology
Osteoarthritis (OA) is a whole-joint disease involving cartilage, synovium, subchondral bone, and neurovascular structures. Synovitis, damage-associated molecular patterns, and interactions between macrophages and fibroblast-like synoviocytes have been ...
Kangyi Hu, Yongjia Song, Jiaxing Pan, Zhiqiang Wang, Weiran Li, Chaoqun Yan, Yongpeng Xue, Xiao Jia, Luhao Yu, Min Song, Jiamin Bao   +10 more
doaj   +2 more sources

Targeting the synovial engine: next-generation engineered immune cells to eradicate pathogenic FLS in rheumatoid arthritis, with safety-first, selective designs [PDF]

Frontiers in Immunology
Rheumatoid arthritis (RA) and associated inflammatory arthritides are characterized by chronic synovial inflammation that drives destructive pannus formation, eroding cartilage and bone.
Ashik Anil Mathew, Arulkumaran Rithvik, Mahaboobkhan Rasool   +2 more
doaj   +2 more sources

Isolation and Characterization of Synovial Mesenchymal Stem Cells Derived From Patients With Chronic Lateral Ankle Instability: A Comparative Analysis of Synovial Fluid, Adipose Synovium, and Fibrous Synovium of the Ankle Joint

Orthopaedic Journal of Sports Medicine, 2022
Background: Synovial mesenchymal stem cells (MSCs) have high proliferative potential and are considered an excellent source for stem cell therapy.
Hirotaka Nakashima MD, PhD, Soshi Uchida MD, PhD, Akihisa Hatakeyama MD, PhD, Yoichi Murata MD, PhD, Yoshiaki Yamanaka MD, PhD, Manabu Tsukamoto MD, PhD, Ichiro Sekiya MD, PhD, Akinori Sakai MD, PhD   +7 more
doaj   +1 more source

Chondrosarcomas of the synovium [PDF]

Cancer, 1991
Chondrosarcoma of the synovium, either primary or secondary to synovial chondromatosis, is rare. Ten cases of synovial chondrosarcoma were studied (four from the Mayo Clinic files and six from the authors' consultation files). Two were considered primary.
F, Bertoni, K K, Unni, J W, Beabout, F H, Sim   +3 more
openaire   +2 more sources

The stressed synovium [PDF]

Arthritis Research & Therapy, 2001
This review focuses on the mechanisms of stress response in the synovial tissue of rheumatoid arthritis. The major stress factors, such as heat stress, shear stress, proinflammatory cytokines and oxidative stress, are discussed and reviewed, focusing on their potential to induce a stress response in the synovial tissue.
Schett, Georg, Tohidast-Akrad, Makiyeh, Steiner, Günter, Smolen, Josef   +3 more
openaire   +2 more sources

Synovium is a sensitive tissue for mapping the negative effects of systemic iron overload in osteoarthritis: identification and validation of two potential targets

Journal of Translational Medicine, 2023
Background The prevention and treatment of osteoarthritis (OA) pose a major challenge in its research. The synovium is a critical tissue in the systematic treatment of OA.
Zhuangzhuang Jin, He Zhang, Lunhao Bai, Lingyu Yue, Weiming Zhang, Jiajian Liang, Bohan Chang, Yue Yang, Zhehan Hu, Liang Chen, Chuanji Guo   +10 more
doaj   +1 more source

Another Look at the Contribution of Oral Microbiota to the Pathogenesis of Rheumatoid Arthritis: A Narrative Review

Microorganisms, 2021
Although autoimmunity contributes to rheumatoid arthritis (RA), several lines of evidence challenge the dogma that it is mainly an autoimmune disorder.
Jean-Marie Berthelot, Octave Nadile Bandiaky, Benoit Le Goff, Gilles Amador, Anne-Gaelle Chaux, Assem Soueidan, Frederic Denis   +6 more
doaj   +1 more source

Pulsed Electromagnetic Field Therapy and Direct Current Electric Field Modulation Promote the Migration of Fibroblast-like Synoviocytes to Accelerate Cartilage Repair In Vitro

Applied Sciences, 2022
Articular cartilage injuries are a common source of joint pain and dysfunction. As articular cartilage is avascular, it exhibits a poor intrinsic healing capacity for self-repair.
Neeraj Sakhrani, Robert M. Stefani, Stefania Setti, Ruggero Cadossi, Gerard A. Ateshian, Clark T. Hung   +5 more
doaj   +1 more source

Pathology of the Synovium [PDF]

American Journal of Clinical Pathology, 2000
Synovium is specialized mesenchymal tissue that is essential for the appropriate function of the locomotor apparatus. It is the site for a series of pathologic processes that are characteristic, and in some cases specific, to this distinctive tissue. In this article, the normal microscopic anatomy of synovium is briefly reviewed. Synovial proliferative
openaire   +2 more sources