Results 21 to 30 of about 43,674 (271)

Digoxin Alleviates Osteoarthritis by Inhibiting Macrophage Extracellular Trap Formation via Disruption of the LSP1-SOD1 Interaction. [PDF]

Adv Sci (Weinh)
Synovial macrophages in osteoarthritis upregulate LSP1, which directly binds and inhibits SOD1, triggering a redox imbalance that activates both NOX and mitochondrial ROS pathways. This cascade drives the release of macrophage extracellular traps (METs), causing chondrocyte damage and disease progression.
Pan Y, Feng X, Liu C, Tong J, Li Z, Liu C, Dong Y, Meng C, Xu Y, Xu W.   +9 more
europepmc   +2 more sources

Bridging Insights From Lymph Node and Synovium Studies in Early Rheumatoid Arthritis

Frontiers in Medicine, 2022
Rheumatoid arthritis (RA) is a chronic autoimmune disease of unknown etiology characterized by inflammation of the peripheral synovial joints leading to pannus formation and bone destruction.
Aoife M. O'Byrne, Aoife M. O'Byrne, Aoife M. O'Byrne, Tineke A. de Jong, Tineke A. de Jong, Tineke A. de Jong, Lisa G. M. van Baarsen, Lisa G. M. van Baarsen, Lisa G. M. van Baarsen   +8 more
doaj   +1 more source

The Synovium in Rheumatoid Arthritis [PDF]

The Open Rheumatology Journal, 2011
Rheumatoid arthritis (RA) is a chronic autoimmune disease targeting multiple joints. The synovium is the primary site of the inflammatory process, which if untreated leads to irreversible damage to the adjacent cartilage and bone. It is now well established that autoantibodies that are characteristic of RA, including rheumatoid factor (RF) and anti ...
Hitchon, Carol A, El-Gabalawy, Hani S
openaire   +2 more sources

Monocytes/macrophages express CCR9 in rheumatoid arthritis and CCL25 stimulates their differentiation [PDF]

, 2010
Introduction: Monocytes/macrophages accumulate in the rheumatoid (RA) synovium where they play a central role in inflammation and joint destruction. Identification of molecules involved in their accumulation and differentiation is important to inform ...
Buckley, Christopher, Helen Williams, Cartwright, A, John HH Williams, Andrew Filer, Schmutz, Caroline, Oliver Haworth, Filer, Andrew, Mike Salmon, Haworth, O, Buckley, Christopher D., Alison Cartwright, Christopher D Buckley, Schmutz, C, Williams, John H. H., Middleton, J, Haworth, Oliver, Buckley, CD, Williams, JH, Cartwright, Alison, Caroline Schmutz, Williams, HJ, Middleton, Jim F., Williams, Helen, Salmon, Mike, Filer, A, Salmon, M, Williams, J, Williams, H, Middleton, Jim F S, Jim Middleton   +30 more
core   +1 more source

Hydraulic permeability and compressive properties of porcine and human synovium [PDF]

, 2022
The synovium is a multilayer connective tissue separating the intra-articular spaces of the diarthrodial joint from the extra-synovial vascular and lymphatic supply. Synovium regulates drug transport into and out of the joint, yet its material properties
Fitzpatrick, James A J, Nommensen, Kayla, Setton, Lori A, Davis, Alexandra L, Rohanifar, Milad, Pham, Christine N, Guang, Young, Johnston, Benjamin B, Fitzpatrick, James A.J., James A.J. Fitzpatrick, Davis, Alexandra L., Kayla Nommensen, Christine N. Pham, Pham, Christine N., Alexandra L. Davis, Benjamin B. Johnston, Setton, Lori A., Milad Rohanifar, Johnston, Benjamin B., Young Guang, Lori A. Setton   +20 more
core   +1 more source

Histopathological synovium outcomes.

, 2020
Histopathological synovium outcomes.
Benedikt L. Proffen (6416381), Martha M. Murray (1337691), Jakob T. Sieker (6416378), Carla M. Haslauer (1337694), Manuela H. Weissenberger (8501250), Matthew L. Warman (224682), Ugur M. Ayturk (8501247), Braden C. Fleming (6254981)   +7 more
core   +1 more source

Synovial chondromatosis originating from the synovium of the anterior cruciate ligament: a case report

Sports Medicine, Arthroscopy, Rehabilitation, Therapy & Technology, 2009
A case of synovial chondromatosis originating from the synovium of the anterior cruciate ligament (ACL) resulting in a mechanical block to knee extension is reported.
Majima Tokifumi, Kamishima Tamotsu, Susuda Kouichi   +2 more
doaj   +1 more source

New Developments in Transcriptomic Analysis of Synovial Tissue

Frontiers in Medicine, 2020
Transcriptomic technologies are constantly changing and improving, resulting in an ever increasing understanding of gene expression in health and disease.
Hayley L. Carr, Jason D. Turner, Triin Major, Dagmar Scheel-Toellner, Andrew Filer, Andrew Filer   +5 more
doaj   +1 more source

Ectopic Lymphoid Structures Support Ongoing Production of Class-Switched Autoantibodies in Rheumatoid Synovium [PDF]

, 2009
BackgroundFollicular structures resembling germinal centres (GCs) that are characterized by follicular dendritic cell (FDC) networks have long been recognized in chronically inflamed tissues in autoimmune diseases, including the synovium of rheumatoid ...
Kelly, Stephen, Kelly, S, Blades, Mark C., Kirkham, Bruce, Spencer, Jo, Frances Humby, Bruce Kirkham, Pitzalis, Costantino, Michele Bombardieri, Kelly Stephen, Mark C Blades, Humby, F, Bombardieri M., Blades, MC, Manzo Antonio, Humby, Frances, Stephen Kelly, Bombardieri, M, Pitzalis C., Bombardieri, Michele, Spencer, J, Humby F., Blades M.C., Bombardieri Michele, Humby Frances, Blades Mark C, Kirkham, B, Kirkham Bruce, Manzo, A, Spencer Jo, Spencer J., MANZO, ANTONIO, Pitzalis Costantino, Antonio Manzo, Pitzalis, C, Kirkham B., Jo Spencer, Costantino Pitzalis, Kelly S.   +38 more
core   +1 more source

Structural changes in the distal articular end of the femur in experimental modeling of osteomyelitis

Гений oртопедии, 2023
Features of structural changes in the joint components (synovial membrane, articular cartilage, subchondral bone) under the conditions of adjacent limb segment osteomyelitis are poorly understood and require thorough histological studies.
Evgeny N. Ovchinnikov, Tatyana A. Stupina, Olga V. Dyuryagina, Nadezhda V. Kubrak, Yulia A. Stupina   +4 more
doaj   +1 more source