Results 11 to 20 of about 43,674 (271)

Distribution of Neuropeptides in the Synovium of Charcot Neuroarthropathy

Foot & Ankle Orthopaedics, 2016
Category: Basic Sciences/Biologics Introduction/Purpose: The pathology of Charcot neuroarthropathy (CNA) presents inflammation, and bone and cartilage destruction. It is still unclear how the neuropathic signals lead to joint inflammation and destruction.
Lew C. Schon MD, Reed Mitchell MS, Talal A. Zahoor MBBS, Zijun Zhang MD, PhD   +3 more
doaj   +2 more sources

Who drives the progress of osteoarthritis? – A descriptive study of synovium-meniscus crosstalk

European Cells & Materials
Objective: The incidence of osteoarthritis (OA) increases with each passing year. The degeneration of the meniscus and synovium is considered the initial factor of knee osteoarthritis (KOA), but their synergistic mechanism has not been clarified. Methods:
F Yu, TT Qi, J Weng, TB Wang, P Liu, YQ Chen, A Xiong, DL Wang, H Zeng   +8 more
doaj   +2 more sources

Short-term overloading exercise attenuates articular chondrocyte features partly via synovium–cartilage interactions mediated by inhibin subunit beta A

Scientific Reports
Excessive mechanical loading leads to cartilage degeneration. However, short-term responses of the synovium and cartilage to overloading and interactions between these tissues remain poorly understood.
Yusuke Arino, Asuka Terashima, Toshiya Tsubaki, Yasuhide Iwanaga, Yasunori Omata, Sakae Tanaka, Taku Saito   +6 more
doaj   +2 more sources

Protective Effect of Normal Synovium on Damaged Cartilage

Orthopaedic Journal of Sports Medicine, 2017
Objectives: Traumatic joint injury results in an acute inflammatory response. If uncontrolled, this can progress to chronic inflammation, which can expedite the onset of post-traumatic osteoarthritis (PTOA).
Adam Blair Yanke MD, Atsushi Urita MD, PhD, Maximilian A. Meyer BS, Brett Madden BS, Susan Chubinskaya PhD, Brian J. Cole MD, MBA   +5 more
doaj   +2 more sources

Targeting human synovium using homing peptides identified by in vivo phage display [PDF]

, 2009
PhDRheumatoid arthritis (RA) is a chronic inflammatory condition affecting diarthrodial synovial joints. Non-random patterns of inflammatory cell recruitment suggest the presence of synovial-specific vascular determinants which enable recruitment of ...
Garrood, Toby
core   +4 more sources

In major joint diseases the human synovium retains its potential to form repair cartilage [PDF]

, 2023
The inner surface layer of human joints, the synovium, is a source of stem cells for the repair of articular cartilage defects. We investigated the potential of the normal human synovium to form novel cartilage and compared its chondrogenic capacity with
Kurt Lippuner, Ernst B. Hunziker, Hunziker, Ernst B, Shintani, Nahoko, Nahoko Shintani, Esther Vögelin, Marius J. B. Keel, Vögelin, Esther, Keel, Marius J B, Lippuner, Kurt   +9 more
core   +2 more sources

Metabolic‐Redox Remodeling of Inflammatory Synovium by Mannose‐Modified Selenium Nanoparticles for Osteoarthritis Therapy [PDF]

Advanced science
Elevated GLUT1‐driven glycolysis and disrupted selenoprotein‐dependent redox homeostasis drive osteoarthritic progression. Intra‐articular mannose‐modified selenium nanoparticles (M‐SeNPs) selectively target hypermetabolic synovial cells to reprogram aberrant glycolysis and restore endogenous antioxidant defenses.
Zou Y, Xu C, Li B, Chan L, Xu Y, Su H, Peng R, Luo F, Peng Y, Li Z, Wong V, Zheng X, Ma X, Zha Z, Chen T, Zhang H.   +15 more
europepmc   +2 more sources

Cellular characterisation of advanced osteoarthritis knee synovium [PDF]

, 2023
Objectives Osteoarthritis (OA) is increasingly recognised as a whole joint disease, with an important role for synovium. However, the repertoire of immune cells and fibroblasts that constitute OA synovium remains understudied.
Mathew J. Baldwin, Andrew J. Price, Abtin Alvand, Lorenzo Ramos-Mucci, Mark C. Coles, Andrew J. Carr, Jolet Y. Mimpen, Stephanie G. Dakin, Dylan Windell, Ananya Bhalla, Sarah J. B. Snelling, Anna Ridley, Christopher D. Buckley, Robert Hedley   +13 more
core   +1 more source

stromal cell network in human rheumatoid arthritis synovium [PDF]

, 2021
Telocytes (TCs)/CD34+ stromal cells have recently emerged as peculiar interstitial cells detectable in a variety of organs throughout the human body. TCs are typically arranged in networks establishing unique spatial relationships with neighbour cells ...
Faussone-Pellegrini, Maria Simonetta, Manetti, Mirko, Rosa, Irene, Matucci-Cerinic, Marco, Ibba-Manneschi, Lidia, Lidia Ibba‐Manneschi, Irene Rosa, Romano, Eloisa, Eloisa Romano, Maria Simonetta Faussone‐Pellegrini, Mirko Manetti, Marco Matucci‐Cerinic   +11 more
core   +1 more source

The Normal Synovium [PDF]

The Open Rheumatology Journal, 2011
This paper describes the structure and function of the normal synovium including the cellular content, nerve and vascular supply and how normal synovium maintains homeostasis within the joint. It is important to understand normal synovium before appreciating the changes that occur in the synovial membrane which leads to the pathology seen in ...
openaire   +2 more sources