Results 31 to 40 of about 43,674 (271)

Interplay Between Iron Overload and Osteoarthritis: Clinical Significance and Cellular Mechanisms

Frontiers in Cell and Developmental Biology, 2022
There are multiple diseases or conditions such as hereditary hemochromatosis, hemophilia, thalassemia, sickle cell disease, aging, and estrogen deficiency that can cause iron overload in the human body.
Chenhui Cai, Wenhui Hu, Tongwei Chu
doaj   +1 more source

Cross-Tissue Transcriptomic Analysis Leveraging Machine Learning Approaches Identifies New Biomarkers for Rheumatoid Arthritis

Frontiers in Immunology, 2021
There is an urgent need to identify biomarkers for diagnosis and disease activity monitoring in rheumatoid arthritis (RA). We leveraged publicly available microarray gene expression data in the NCBI GEO database for whole blood (N=1,885) and synovial (N ...
Dmitry Rychkov, Dmitry Rychkov, Dmitry Rychkov, Jessica Neely, Tomiko Oskotsky, Steven Yu, Steven Yu, Noah Perlmutter, Joanne Nititham, Alexander Carvidi, Melissa Krueger, Andrew Gross, Lindsey A. Criswell, Lindsey A. Criswell, Lindsey A. Criswell, Lindsey A. Criswell, Judith F. Ashouri, Marina Sirota, Marina Sirota   +18 more
doaj   +1 more source

Rituximab versus tocilizumab and B-cell status in TNF-alpha inadequate-responder rheumatoid arthritis patients: the R4-RA RCT

Efficacy and Mechanism Evaluation, 2022
Background: Although biological therapies have transformed the outlook for those with rheumatoid arthritis, there is a lack of any meaningful response in approximately 40% of patients.
Frances Humby, Patrick Durez, Maya H Buch, Myles J Lewis, Michele Bombardieri, Christopher John, Hasan Rizvi, Louise Warren, Joanna Peel, Liliane Fossati-Jimack, Rebecca E Hands, Giovanni Giorli, Felice Rivellese, Juan D Cañete, Peter C Taylor, Peter Sasieni, João E Fonseca, Ernest Choy, Costantino Pitzalis   +18 more
doaj   +1 more source

Addition of High Molecular Weight Hyaluronic Acid to Fibroblast-Like Stromal Cells Modulates Endogenous Hyaluronic Acid Metabolism and Enhances Proteolytic Processing and Secretion of Versican

Cells, 2020
We have examined the effect of exogenous linear chain high molecular weight hyaluronic acid (HMW HA) on endogenously synthesized hyaluronic acid (HA) and associated binding proteins in primary cultures of fibroblast-like stromal cells that were obtained ...
Jiapeng Xue, Jinnan Chen, Quan Shen, Deva Chan, Jun Li, Adam P. Tanguay, Tannin A. Schmidt, Faizan Niazi, Anna Plaas   +8 more
doaj   +1 more source

Role of shear wave elastography of synovium to differentiate rheumatoid and tubercular arthritis

Journal of Medical Ultrasound, 2022
Background: Synovitis is the underlying pathology in various arthritis, and sometimes, it is difficult to differentiate various arthritis clinically or even by imaging.
Karamvir Chandel, Mahesh Prakash, Anindita Sinha, Aman Sharma, Devendra K Chouhan, Manavjit Singh Sandhu   +5 more
doaj   +1 more source

Adipose derived Stromal Vascular Fraction (SVF) cells in the treatment of rheumatoid arthritis of the hand: a 2-year follow-up study [PDF]

CellR4, 2019
OBJECTIVE: Rheumatoid arthritis of the hand constitutes a debilitating aspect of this chronic autoimmune disease. Conventional management with medication is difficult with many side effects. The anti-inflammatory properties of autologous stromal vascular
M. Carstens, J. Montenegro, A. Gómez, D. Correa   +3 more
doaj   +1 more source

Eucommia ulmoides Polysaccharides Attenuate Rabbit Osteoarthritis by Regulating the Function of Macrophages

Frontiers in Pharmacology, 2021
Background and purpose:Eucommia ulmoides polysaccharides (EUP) can regulate the immunity of macrophages, but the functional status of macrophages is related to osteoarthritis and synovial inflammation.
Yaqiong Sun, Kui Huang, Linhai Mo, Akhlaq Ahmad, Dejia Wang, Zijie Rong, Honghui Peng, Honghua Cai, Guihua Liu   +8 more
doaj   +1 more source

Transcriptional response of synovium to joint injury.

, 2020
Transcriptional response of synovium to joint injury.
Benedikt L. Proffen (6416381), Martha M. Murray (1337691), Jakob T. Sieker (6416378), Carla M. Haslauer (1337694), Manuela H. Weissenberger (8501250), Matthew L. Warman (224682), Ugur M. Ayturk (8501247), Braden C. Fleming (6254981)   +7 more
core   +1 more source

The synovium of human osteoarthritic joints retains its chondrogenic potential irrespective of age. [PDF]

, 2022
The autologous synovium is a potential tissue source for local induction of chondrogenesis by tissue engineering approaches to repair articular cartilage defects such as they occur in osteoarthritis.
Keel, Marius J, Hunziker, Ernst B., Shintani, Nahoko, Voegelin, Esther, Haspl, Miroslav, Lippuner, Kurt, Kurt Lippuner, Ernst B. Hunziker, Marius J.B. Keel, Nahoko Shintani, Miroslav Haspl, Esther Vögelin   +11 more
core   +2 more sources

Association of the Rheumatoid Arthritis Severity Variant rs26232 with the Invasive Activity of Synovial Fibroblasts

Cells, 2019
rs26232, located in intron one of C5orf30, is associated with the susceptibility to and severity of rheumatoid arthritis (RA). Here, we investigate the relationship between this variant and the biological activities of rheumatoid arthritis synovial ...
Emma R Dorris, Eimear Linehan, Michelle Trenkmann, Douglas J Veale, Ursula Fearon, Anthony G. Wilson   +5 more
doaj   +1 more source