Results 51 to 60 of about 43,674 (271)

β2-Adrenoceptor Deficiency Results in Increased Calcified Cartilage Thickness and Subchondral Bone Remodeling in Murine Experimental Osteoarthritis

Frontiers in Immunology, 2022
PurposeRecent studies demonstrated a contribution of adrenoceptors (ARs) to osteoarthritis (OA) pathogenesis. Several AR subtypes are expressed in joint tissues and the β2-AR subtype seems to play a major role during OA progression.
Gundula Rösch, Dominique Muschter, Shahed Taheri, Karima El Bagdadi, Christoph Dorn, Andrea Meurer, Frank Zaucke, Arndt F. Schilling, Susanne Grässel, Rainer H. Straub, Zsuzsa Jenei-Lanzl   +10 more
doaj   +1 more source

A Decoy‐Receptor‐Armed Biomimetic Nanotherapeutic With Inherent Tropism for Conserved Pathogenic Macrophages for Treating Osteoarthritis and Intervertebral Disc Degeneration

Advanced Science, EarlyView.
A biomimetic doppelgänger nanosystem neutralizes extracellular inflammatory cytokines and silences intracellular pyroptosis, reprogramming pathogenic macrophages to attenuate both joint and spine degeneration. ABSTRACT Osteoarthritis (OA) and intervertebral disc degeneration (IVDD) are debilitating musculoskeletal disorders driven by shared ...
Fudong Li, Bin Zhang, Zhiqiu Zhang, Bing Zheng, Linhui Han, Chen Yan, Jialin Li, Kaiqiang Sun, Tianyi Zhao, Jiangang Shi   +9 more
wiley   +1 more source

Immunohistochemistry of synovium.

, 2014
To observe the expression of TTR in synovium (RA, n = 3 and OA, n = 3), IHC were performed. Tissue samples were fixed, processed and stained with DAB. Brown colour indicates the presence of autoantigen in synovium. Upper panel shows the image of synovial
Sagarika Biswas (281819), Taposh Kumar Das (548992), Darshan Singh Bhakuni (548991), Rajesh Malhotra (281822), Onkar Prasad Garg (548989), Lalit Kumar Singh (519938), Ashish Sarkar (548988), Sreejoyee Ghosh (548987), Radhey Shyam Sharma (548990), Saurabh Sharma (281820), Yogendra Singh (8247)   +10 more
core   +1 more source

Effects of NO synthase inhibitors on the synovial microcirculation in the mouse knee joint [PDF]

, 1999
Production of nitric oxide by the inducible NO synthase (iNOS) is known to be enhanced in chronic joint inflammation and osteoarthritis as well as aseptic loosening of joint prostheses.
Refior, H. J., Messmer, K., Krombach, F., Veihelmann, A.   +3 more
core   +1 more source

Comprehensive bulk and single-cell transcriptome profiling give useful insights into the characteristics of osteoarthritis associated synovial macrophages

Frontiers in Immunology, 2023
BackgroundOsteoarthritis (OA) is a common chronic joint disease, but the association between molecular and cellular events and the pathogenic process of OA remains unclear.ObjectiveThe study aimed to identify key molecular and cellular events in the ...
Shengyou Liao, Ming Yang, Dandan Li, Ye Wu, Ye Wu, Hong Sun, Jingxiao Lu, Xinying Liu, Tingting Deng, Yujie Wang, Ni Xie, Donge Tang, Guohui Nie, Guohui Nie, Xiaoqin Fan, Xiaoqin Fan   +15 more
doaj   +1 more source

Engineered Cyanobacteria‐Hydrogel Microecological System for Oxygen Reprogramming Synergizes Immunomodulation With Anabolism in Osteoarthritis Therapy

Advanced Science, EarlyView.
An injectable cyanobacteria‐laden hydrogel enables light‐dependent oxygen metabolism engineering for osteoarthritis therapy. Photosynthetic oxygen release under red light irradiation suppresses synovial inflammation via HIF‐1α inhibition and M2 macrophage polarization, while respiratory oxygen consumption in darkness stabilizes chondrocyte HIF‐1α to ...
Lerong Yang, Chong Shen, Hongjun Huang, Siyi Liu, Zeyu Huang, Licheng Xi, Huan Cao, Li Zheng, Zainen Qin   +8 more
wiley   +1 more source

Quantitation of TTR in synovium by Western blotting.

, 2014
Protein (50 μg) of RA synovium (n = 7) and OA synovium (n = 7) was loaded in SDS-PAGE gels, the proteins were separated and transferred onto nitrocellulose.
Sagarika Biswas (281819), Taposh Kumar Das (548992), Darshan Singh Bhakuni (548991), Rajesh Malhotra (281822), Onkar Prasad Garg (548989), Lalit Kumar Singh (519938), Ashish Sarkar (548988), Sreejoyee Ghosh (548987), Radhey Shyam Sharma (548990), Saurabh Sharma (281820), Yogendra Singh (8247)   +10 more
core   +1 more source

Responding to ACL Injury and its Treatments: Comparative Gene Expression between Articular Cartilage and Synovium

, 2023
The relationship between cartilage and synovium is a rapidly growing area of osteoarthritis research. However, to the best of our knowledge, the relationships in gene expression between these two tissues have not been explored in mid-stage disease ...
Jonah I. Donnenfield, Benedikt L. Proffen, Martha M. Murray, Braden C. Fleming   +3 more
core   +1 more source

CircRNAs in osteoarthritis: research status and prospect

Frontiers in Genetics, 2023
Osteoarthritis (OA) is the most common joint disease globally, and its progression is irreversible. The mechanism of osteoarthritis is not fully understood.
Zhuang Li, Jun Lu
doaj   +1 more source

Activation of rat synovium by iron [PDF]

Arthritis & Rheumatism, 1988
AbstractWe observed a consistent sequence of activation changes in rat knee synovia following a single intravenous injection of sterile ferric citrate at a dosage sufficient to cause a transient saturation of transferrin. The initial alteration, appreciated 2 hours postinjection, consisted of an expansion in the lumen of synovial capillaries.
M, de Sousa, R, Dynesius-Trentham, F, Mota-Garcia, M T, da Silva, D E, Trentham   +4 more
openaire   +2 more sources