Results 61 to 70 of about 43,674 (271)

Multi‐Technique Integration Identifies O‐GlcNAc Transferase in Fibroblast‐Like Synoviocytes as a Therapeutic Target for Rheumatoid Arthritis

Advanced Science, EarlyView.
AI‑guided single‑cell transcriptomics identifies OGT as a key regulator enriched in rheumatoid arthritis fibroblast‑like synoviocytes (RA‐FLSs). Inflammatory stimuli activate the OGT–SAP130 axis, which modulates the H3K27ac/H3K27me3 balance and epigenetically silences BTG2, promoting aggressive transformation of RA‑FLSs.
Duoli Xie, Jie Huang, Chunhao Cao, Zhenchao Tang, Xingchen Li, Jianmin Guo, Xinxin Chen, Fang Wang, Dongyi He, Jie Li, Yu Du, Bing He, Jianhua Yao, Aiping Lu, Chao Liang   +14 more
wiley   +1 more source

TGFBI Maintains Fibrocartilage Homeostasis by Restraining O‐GlcNAcylation to Inactivate and Destabilize ADAMTS16 in Temporomandibular Joint Osteoarthritis

Advanced Science, EarlyView.
TGFBI deficiency elevates O‐GlcNAcylation, promoting the transcriptional activation of ADAMTS16 and OGT‐mediated post‐translational modification of ADAMTS16 at Ser1170. This leads to its stabilization and accumulation, driving chondrocyte metabolic disorders and senescent phenotypes, ultimately resulting in fibrocartilage dysfunction and TMJOA ...
Xin Liu, Xinyue Luo, Jie Zhao, Ziyan Jiang, Jiayi Zhai, Taomin Zhu, Xueke Jia, Xiaohan Ma, Henghua Jiang, Huimin Li, Yaping Feng, Jin Ke, Xing Long   +12 more
wiley   +1 more source

Fibroblasts in rheumatoid arthritis: novel roles in joint inflammation and beyond

Frontiers in Medicine
High-throughput technologies in human and animal studies have revealed novel molecular and cellular pathways involved in tissue inflammation of rheumatoid arthritis (RA).
Elpida Neofotistou-Themeli, Elpida Neofotistou-Themeli, Panagiota Goutakoli, Panagiota Goutakoli, Theodoros Chanis, Theodoros Chanis, Maria Semitekolou, Maria Semitekolou, Eirini Sevdali, Eirini Sevdali, Prodromos Sidiropoulos, Prodromos Sidiropoulos   +11 more
doaj   +1 more source

Fibrous Synovium Releases Higher Numbers of Mesenchymal Stem Cells Than Adipose Synovium in a Suspended Synovium Culture Model [PDF]

Arthroscopy, 2016
Purpose To develop an in vitro model, the “suspended synovium culture model,” to demonstrate the mobilization of mesenchymal stem cells (MSCs) from the synovium into a noncontacted culture dish through culture medium.
Katagiri, Kenta, Matsukura, Yu, Muneta, Takeshi, Ozeki, Nobutake, Mizuno, Mitsuru, Katano, Hisako, Sekiya, Ichiro   +6 more
openaire   +2 more sources

Effects of Diet Induced Weight Reduction on Cartilage Pathology and Inflammatory Mediators in the Joint Tissues

Frontiers in Medicine, 2021
Obesogenic diets contribute to the pathology of osteoarthritis (OA) by altering systemic and local metabolic inflammation. Yet, it remains unclear how quickly and reproducibly the body responds to weight loss strategies and improve OA.
Antonia RuJia Sun, Antonia RuJia Sun, Xiaoxin Wu, Xiaoxin Wu, Ross Crawford, Ross Crawford, Hongxing Li, Lin Mei, Yong Luo, Yin Xiao, Yin Xiao, Xinzhan Mao, Indira Prasadam   +12 more
doaj   +1 more source

Multi‐Tissue Crosstalk Regulating Meniscus Healing Under Inflammation and Physiological Loading

Advanced Science, EarlyView.
Using a novel Meniscus‐on‐a‐chip (MoC) model integrated with a meniscus‐specific bioreactor, this study investigated the roles of multi‐tissue crosstalk that regulates injury, healing, and degeneration of the meniscus injury under inflammation and pathophysiological loading.
Hun Jin Jeong, Elen Zhu, Min Seo Kang, Ming Wang, Sam Comito, Chang H. Lee   +5 more
wiley   +1 more source

Bioenergetic Materials for Tissue Regeneration: Modulating Metabolism to Promote Cellular Anabolism

Advanced Science, EarlyView.
Bioenergetic materials (BEMs) modulate cellular metabolism to promote tissue regeneration. Their principal mechanisms of action include metabolic substrate supplementation, metabolic enzyme modulation, organelle transfer, electrical current regulation, redox homeostasis modulation, and oxygen tension modulation.
Yuchen He, Yuwen Wang, Jonathan F. Gong, Yiting Lei, Fei Jin, Weihong Zhu, Rocky S. Tuan, Zhong Alan Li   +7 more
wiley   +1 more source

A synovium specific gene signature in low serum.

, 2015
Panel A shows a Venn diagram showing the overlap between genes differentially expressed in synovium, bone marrow and skin derived fibroblasts between RA and OA groups in the low serum state. The high degree of overlap between skin and bone marrow and the
Holly M. Legault (214386), Mark J. Pearson (712103), Christopher D. Buckley (74993), Karim Raza (23437), Philipp Antczak (226100), Greg N. Parsonage (712101), Francesco Falciani (8906), Dagmar Scheel-Toellner (68012), Andrew Filer (23434), Andrew M. Thomas (712104), Margot O’Toole (712102)   +10 more
core   +1 more source

Heterogeneity of active mast cells, endothelial cells, and fibroblasts in hemophilic arthritis defined by synovial single-cell sequencing

Scientific Reports
Recurrent synovial bleeding is the major cause of Hemophilic Arthritis (HA). Up to now, the transcriptomic profiles of bleeding syvonium in HA patient have largely remained unknown.
Kun Lin, Shuai Fan, Xiaoqiang Yang, Wenyuan Hou, Junjiao Zhang, Jiaru Liao, Longfei Han, Peng Peng, Fangjun Xiao, Weihua Fang, Xianshun He, Jiaqing Tian, Shun Lu, Fan Yang, Qiushi Wei, Mincong He   +15 more
doaj   +1 more source

Toward Development of a Diabetic Synovium Culture Model

Frontiers in Bioengineering and Biotechnology, 2022
Osteoarthritis (OA) is a degenerative joint disease characterized by articular cartilage degradation and inflammation of synovium, the specialized connective tissue that envelops the diarthrodial joint.
Neeraj Sakhrani, Andy J. Lee, Lance A. Murphy, Hagar M. Kenawy, Christopher J. Visco, Gerard A. Ateshian, Gerard A. Ateshian, Roshan P. Shah, Clark T. Hung, Clark T. Hung   +9 more
doaj   +1 more source