Results 61 to 70 of about 19,285 (227)

Pyroptosis for osteoarthritis treatment: insights into cellular and molecular interactions inflammatory

Frontiers in Immunology
Osteoarthritis (OA) is a widely prevalent chronic degenerative disease often associated with significant pain and disability. It is characterized by the deterioration of cartilage and the extracellular matrix (ECM), synovial inflammation, and subchondral
Minghui Lin, Cunxin Zhang, Haiming Li, Kang Li, Shuao Gou, Xiao He, Xiao He, Chaoliang Lv, Kai Gao   +8 more
doaj   +1 more source

The autocrine role of proteoglycan-4 (PRG4) in modulating osteoarthritic synoviocyte proliferation and expression of matrix degrading enzymes

Arthritis Research & Therapy, 2017
Background Lubricin/proteoglycan 4 (PRG4) is a mucinous glycoprotein secreted by synovial fibroblasts and superficial zone chondrocytes. Recently, we showed that recombinant human PRG4 (rhPRG4) is a putative ligand for CD44 receptor.
Ali Alquraini, Maha Jamal, Ling Zhang, Tannin Schmidt, Gregory D. Jay, Khaled A. Elsaid   +5 more
doaj   +1 more source

Composition of allogeneic equine orthobiologics and their repeated intra‐articular administrations

Equine Veterinary Journal, EarlyView.
Abstract Background Orthobiologics such as platelet‐rich plasma (PRP) and alpha‐2‐macroglobulin (A2MG) are increasingly used for equine musculoskeletal injuries. However, their composition and safety with repeated allogeneic intra‐articular administration remain poorly investigated.
Yanne Van Reusel, Sarah Y. Broeckx, Anna Carolo, Marco Patruno, Jonas Steenbrugge, Jimmy Saunders, Enrico Gugliandolo, Jan H. Spaas   +7 more
wiley   +1 more source

SYNOVIOCYTES, NOT CHONDROCYTES, RELEASE FREE RADICALS AFTER CYCLES OF ANOXIA/RE-OXYGENATION

, 2007
Introduction : An oxidant activity has been implicated in the onset of equine osteoarthritis. Most of the studies have been done on articular chondrocytes, but little is known about the role of synoviocytes.
Schneider, Nicole, Lejeune, Jean-Philippe, Mouithys-Mickalad, Ange, Dupont, Ginette, Serteyn, Didier   +4 more
core   +1 more source

Small Extracellular Vesicles from adipose derived stromal cells significantly attenuate in vitro the NF-κB dependent inflammatory/catabolic environment of osteoarthritis

Scientific Reports, 2021
The therapeutic ability of Mesenchymal Stem/Stromal Cells to address osteoarthritis (OA) is mainly related to the secretion of biologically active factors, which can be found within their secreted Extracellular Vesicles including small Extracellular ...
Carola Cavallo, Giulia Merli, Rosa Maria Borzì, Nicoletta Zini, Stefania D’Adamo, Michele Guescini, Brunella Grigolo, Alessandro Di Martino, Spartaco Santi, Giuseppe Filardo   +9 more
doaj   +1 more source

Tofacitinib Regulates β‐Catenin Nuclear Translocation to Inhibit FLS Migration and Alleviate Clinical Symptoms of RA

iNew Medicine, EarlyView.
ABSTRACT Objective Tofacitinib is a Janus kinase (JAK) inhibitor approved for the treatment of moderate‐to‐severe rheumatoid arthritis (RA). However, its synovium‐related molecular mechanisms, particularly its regulatory effect on fibroblast‐like synoviocyte (FLS) migration, remain incompletely understood.
Shuqi Fang, Tianjing Zhang, Ling Hu, Ruijin Liu, Leyi Jia, Menglin Bai, Jiale Dong, Yuchen Zhao, Han Wang, Lei Zhang, Tao Li, Youcai Deng, Xianzheng Zhang, Lingling Zhang   +13 more
wiley   +1 more source

Human rheumatoid synoviocytes express functional P2X7 receptors

, 2008
Human type B synoviocytes are involved in joint injury during rheumatic diseases by producing inflammatory mediators such as interleukin-6 (IL-6). The increased level of purine and pirimidine nucleotides in the synovial fluid of rheumatoid arthritis (RA)
Capecchi, PIER LEOPOLDO, Lazzerini, PIETRO ENEA, Pietro Enea Lazzerini, Alessandra Gamberucci, Franco Laghi Pasini, Lorenzini, S., Gamberucci, Alessandra, Pompella, G., Enrico Selvi, Natale, M., Gerarda Pompella, LAGHI PASINI, Franco, Mariarita Natale, Francesca Caporali, Selvi, E., Galeazzi, Mauro, Caporali, F., Sauro Lorenzini, Mauro Galeazzi, Pier Leopoldo Capecchi   +19 more
core   +1 more source

IGF2BP3 Overexpression Accelerates Osteoarthritis Progression by Promoting Glycolysis via m6A‐Dependent Stabilization of ECM1 mRNA

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT N6‐methyladenosine (m6A) plays a critical role in osteoarthritis (OA) pathogenesis. This study investigates the role of the m6A reader insulin‐like growth factor 2 mRNA‐binding protein 3 (IGF2BP3) in OA progression. OA models were established in vivo through destabilization of the medial meniscus (DMM) surgery in mice and in vitro by ...
Xing‐Shi Yuan, Hao‐Jie Zhang, Jia‐Xiang Ding, Zheng‐Liang Luo, Min Chen, Xiao‐Qi Zhang, Xi‐Fu Shang, Zhe Ni, Ke‐Rong Wu   +8 more
wiley   +1 more source

Unique Localization of Protein Gene Product 9.5 in Type B Synoviocytes in the Joints of the Horse

, 1999
Fibroblast-like (Type B) synoviocytes are cells in the synovial membrane that are responsible for production of both synovial fluid and the extracellular matrix in the synovial intima.
Haruko Yanase, Hiroshi Kitamura, Hiroko P. Kitamura, Toshihiko Iwanaga   +3 more
core   +1 more source

Folate Deficiency Triggered Apoptosis of Synoviocytes: Role of Overproduction of Reactive Oxygen Species Generated via NADPH Oxidase/Mitochondrial Complex II and Calcium Perturbation. [PDF]

PLoS ONE, 2016
Despite a plethora of literature has documented that osteoarthritis (OA) is veritably associated with oxidative stress-mediated chondrocyte death and matrix degradation, yet the possible involvement of synoviocyte abnormality as causative factor of OA ...
Hung-Chih Hsu, Wen-Ming Chang, Jin-Yi Wu, Chin-Chin Huang, Fung-Jou Lu, Yi-Wen Chuang, Pey-Jium Chang, Kai-Hua Chen, Chang-Zern Hong, Rang-Hui Yeh, Tsan-Zon Liu, Ching-Hsein Chen   +11 more
doaj   +1 more source