Results 1 to 10 of about 231,673 (393)

Chondrocytes Transdifferentiate into Osteoblasts in Endochondral Bone during Development, Postnatal Growth and Fracture Healing in Mice [PDF]

PLoS Genetics, 2014
One of the crucial steps in endochondral bone formation is the replacement of a cartilage matrix produced by chondrocytes with bone trabeculae made by osteoblasts. However, the precise sources of osteoblasts responsible for trabecular bone formation have
Benoit De Crombrugghe
exaly   +3 more sources

The β-catenin/TCF-4 pathway regulates the expression of OPN in human osteoarthritic chondrocytes [PDF]

Journal of Orthopaedic Surgery and Research, 2020
Background Cartilage destruction is the main characteristic of osteoarthritis (OA), and osteopontin (OPN) is elevated in OA articular cartilage; however, the reason for the increased OPN level is not determined.
Jian Tian, Shu-Guang Gao, Yu-Sheng Li, Chao Cheng, Zhen-Han Deng, Wei Luo, Fang-Jie Zhang   +6 more
doaj   +2 more sources

Autophagy plays a protective role in advanced glycation end products- induced apoptosis of chondrocytes via regulation of tumor necrosis factor-α , nuclear factor-κ B and reactive oxygen species

Asian Pacific Journal of Tropical Medicine, 2018
Objective: To study the adverse effects of advanced glycation end products (AGEs) on chondrocytes and the role of autophagy in this process. Methods: Chondrocytes were harvested from the human articular cartilage tissues in surgery.
Zhi-Jiang Sun, Ya-Yi Xia
doaj   +2 more sources

Osteoarthritis-Induced Metabolic Alterations of Human Hip Chondrocytes

Biomedicines, 2022
Osteoarthritis (OA) alters chondrocyte metabolism and mitochondrial biology. We explored whether OA and non-OA chondrocytes show persistent differences in metabolism and mitochondrial function and different responsiveness to cytokines and cAMP modulators.
Annett Eitner, Simon Sparing, Felix C. Kohler, Sylvia Müller, Gunther O. Hofmann, Thomas Kamradt, Hans-Georg Schaible, Matthias Aurich   +7 more
doaj   +1 more source

Combination of chondrocytes and chondrons improves extracellular matrix production to promote the repairs of defective knee cartilage in rabbits

Journal of Orthopaedic Translation, 2021
Background: Chondrons are composed of chondrocytes and the surrounding pericellular matrix (PCM) and function to enhance chondrocyte-mediated cartilage tissue engineering.
Wangping Duan, Yu Zhao, Xiaochun Ren, Ruipeng Zhao, Qi Li, Zhenwei Sun, Wenjie Song, Yanfei Yang, Pengcui Li, Xiaochun Wei   +9 more
doaj   +1 more source

miR-107 affects cartilage matrix degradation in the pathogenesis of knee osteoarthritis by regulating caspase-1

Journal of Orthopaedic Surgery and Research, 2021
Background Knee osteoarthritis (KOA) seriously affects the quality of life of KOA patients. This study aimed to investigate whether miR-107 could regulate KOA through pyroptosis to affect collagen protein secreted by chondrocytes through IL-1β.
Jiatian Qian, Peiliang Fu, Shiao Li, Xiang Li, Yancheng Chen, Zhenen Lin   +5 more
doaj   +1 more source

Effect of growth hormone releasing hormone on chondrocytes of osteoarthritis [PDF]

The Korean Journal of Internal Medicine, 2022
Background/Aims To evaluate the effect and possible mechanism of growth hormone releasing hormone (GHRH) on chondrocytes of osteoarthritis (OA). Methods Articular chondrocytes were cultured and the expression of GHRH receptor in chondrocytes was detected.
Zhuoran LI, Yao LI
doaj   +1 more source

Effect of age and cytoskeletal elements on the indentation-dependent mechanical properties of chondrocytes. [PDF]

, 2013
Articular cartilage chondrocytes are responsible for the synthesis, maintenance, and turnover of the extracellular matrix, metabolic processes that contribute to the mechanical properties of these cells.
Blanchette, Craig, Chahine, Nadeen O, Haudenschild, Dominik, Loots, Gabriela G, Lu, Jeffrey, Thomas, Cynthia B   +5 more
core   +7 more sources

Dysregulation of Cells Cycle and Apoptosis in Human Induced Pluripotent Stem Cells Chondrocytes Through p53 Pathway by HT-2 Toxin: An in vitro Study

Frontiers in Genetics, 2021
Kashin–Beck disease (KBD) mainly damages growth plate of adolescents and is susceptible to both gene and gene–environmental risk factors. HT-2 toxin, which is a primary metabolite of T-2 toxin, was regarded as one of the environmental risk factors of KBD.
Yanan Zhang, Yanan Zhang, Huan Liu, Huan Liu, Xialu Lin, Xialu Lin, Feng’e Zhang, Feng’e Zhang, Peilin Meng, Peilin Meng, Sijia Tan, Sijia Tan, Mikko J. Lammi, Mikko J. Lammi, Xiong Guo, Xiong Guo   +15 more
doaj   +1 more source

Flightless I is a catabolic factor of chondrocytes that promotes hypertrophy and cartilage degeneration in osteoarthritis

iScience, 2021
Summary: Synovial macrophages that are activated by cartilage fragments initiate synovitis, a condition that promotes hypertrophic changes in chondrocytes leading to cartilage degeneration in OA.
Taku Ebata, Mohamad Alaa Terkawi, Masanari Hamasaki, Gen Matsumae, Tomohiro Onodera, Mahmoud Khamis Aly, Shunichi Yokota, Hend Alhasan, Tomohiro Shimizu, Daisuke Takahashi, Kentaro Homan, Ken Kadoya, Norimasa Iwasaki   +12 more
doaj   +1 more source