Results 11 to 20 of about 231,673 (393)
Proceedings of the National Academy of Sciences of the United States of America, 2021 Significance Osteoarthritis is a global health problem that affects load-bearing joints, causing loss of mobility and enormous healthcare costs. However, disease-modifying approaches are lacking.
Whasil Lee +9 more
semanticscholar +1 more source
Journal of Cellular and Molecular Medicine, 2021 Temporomandibular joint (TMJ) osteoarthritis is a common chronic degenerative disease of the TMJ. In order to explore its aetiology and pathological mechanism, many animal models and cell models have been constructed to simulate the pathological process ...
Baochao Li +4 more
semanticscholar +1 more source
Cartilage, 2021 Purpose of Review Mitochondria are recognized to be one of the most important organelles in chondrocytes for their role in triphosphate (ATP) generation through aerobic phosphorylation.
Shiyi Kan +4 more
semanticscholar +1 more source
LDHA-mediated ROS generation in chondrocytes is a potential therapeutic target for osteoarthritis
Nature Communications, 2020 The contribution of inflammation to the chronic joint disease osteoarthritis (OA) is unclear, and this lack of clarity is detrimental to efforts to identify therapeutic targets.
Manoj Arra +11 more
semanticscholar +1 more source
Cells, 2021 Articular cartilage is a connective tissue lining the surfaces of synovial joints. When the cartilage severely wears down, it leads to osteoarthritis (OA), a debilitating disease that affects millions of people globally.
A. Sebastian +6 more
semanticscholar +1 more source
Chondrocytes in the resting zone of the growth plate are maintained in a Wnt-inhibitory environment
eLife, 2021 Chondrocytes in the resting zone of the postnatal growth plate are characterized by slow cell cycle progression, and encompass a population of parathyroid hormone-related protein (PTHrP)-expressing skeletal stem cells that contribute to the formation of ...
Shawn A Hallett +10 more
doaj +1 more source
In vitro and in vivo validation of human and goat chondrocyte labeling by green fluorescent protein lentivirus transduction [PDF]
, 2010 We investigated whether human articular chondrocytes can be labeled efficiently and for long-term with a green fluorescent protein (GFP) lentivirus and whether the viral transduction would influence cell proliferation and tissue-forming capacity.
Acharya, Chitrangada +9 more
core +1 more source
Applied Sciences, 2022 The aim of the study was to assess the effects of therapeutic ultrasound (US) on oxidative stress (OS)-induced changes in cultured human chondrocytes (HCH). For this, monolayer HCH were randomized in three groups: a control group (CG), a group exposed to
Rodica Ana Ungur +14 more
doaj +1 more source
Are Chondrocytes Overlying Cam Morphology Suitable for Therapeutic Use?
Orthopaedic Journal of Sports Medicine, 2020 Objectives: Cam-type femoroacetabular impingement (FAI) results in extra bone and cartilage on the anterolateral femoral head-neck junction, causing abnormal contact between the femur and the acetabulum. We investigated whether chondrocytes isolated from
Mitchell Coleman, Robert Westermann MD
doaj +1 more source
Comparison of Apoptosis and Autophagy in Human Chondrocytes Induced by the T-2 and HT-2 Toxins
Toxins, 2019 In this report, we have investigated the apoptosis and autophagy of chondrocytes induced by the T-2 and HT-2 toxins. The viability of chondrocytes was measured by the MTT assay.
Fang-Fang Yu +4 more
doaj +1 more source