Results 11 to 20 of about 101,193 (316)

The hypertrophic chondrocyte: To be or not to be.

Histology and histopathology, 2021
Hypertrophic chondrocytes are the master regulators of endochondral ossification; however, their ultimate cell fates cells remain largely elusive due to their transient nature. Historically, hypertrophic chondrocytes have been considered as the terminal state of growth plate chondrocytes, which are destined to meet their inevitable demise at the ...
Hallett, Shawn A., Ono, Wanida, Ono, Noriaki   +2 more
openaire   +2 more sources

The emerging chondrocyte channelome [PDF]

Frontiers in Physiology, 2010
Chondrocytes are the resident cells of articular cartilage and are responsible for synthesizing a range of collagenous and non-collagenous extracellular matrix macromolecules. Whilst chondrocytes exist at low densities in the tissue (1-10% of the total tissue volume in mature cartilage) they are extremely active cells and are capable of responding to a
Barrett-Jolley, R, Lewis, R, Fallman, R, Mobasheri, A   +3 more
openaire   +5 more sources

Are ankle chondrocytes from damaged fragments a suitable cell source for cartilage repair? [PDF]

, 2010
To characterize the post-expansion cartilage-forming capacity of chondrocytes harvested from detached fragments of osteochondral lesions (OCLs) of ankle joints (Damaged Ankle Cartilage Fragments, DACF), with normal ankle cartilage (NAC) as ...
Miot, S, Bonacina, E, Martin, I, Jakob, M, Valderrabano, V., Barbero, A, Bonacina, E., Jakob, M., Wolf, F, Valderrabano, V, Wirz, D., Barbero, A., Dickinson, S., Miot, S., Wolf, F., Martin, I., Candrian, C., Dickinson, SC, Candrian, C, Wirz, D   +19 more
core   +1 more source

Intra-individual comparison of human ankle and knee chondrocytes in vitro: relevance for talar cartilage repair [PDF]

, 2009
OBJECTIVE: As compared to knee chondrocytes (KC), talar chondrocytes (TC) have superior synthetic activity and increased resistance to catabolic stimuli. We investigated whether these properties are maintained after TC are isolated and expanded in vitro.
Bonacina, E, Martin, I, Jakob, M, Frueh, J. A., Barbero, A, Bonacina, E., Jakob, M., Heberer, M, Frueh, JA, Frueh, J.A., Wirz, D., Vonwil, D., Barbero, A., Dickinson, S., Martin, I., Candrian, C., Heberer, M., Vonwil, D, Dickinson, SC, Candrian, C, Wirz, D   +20 more
core   +1 more source

Comparison of Apoptosis and Autophagy in Human Chondrocytes Induced by the T-2 and HT-2 Toxins

Toxins, 2019
In this report, we have investigated the apoptosis and autophagy of chondrocytes induced by the T-2 and HT-2 toxins. The viability of chondrocytes was measured by the MTT assay.
Fang-Fang Yu, Xia-Lu Lin, Xi Wang, Zhi-Guang Ping, Xiong Guo   +4 more
doaj   +1 more source

Mitochondrial transfer from bone-marrow-derived mesenchymal stromal cells to chondrocytes protects against cartilage degenerative mitochondrial dysfunction in rats chondrocytes

Chinese Medical Journal, 2021
. Background. Previous studies have reported that mitochondrial dysfunction participates in the pathological process of osteoarthritis (OA). However, studies that improve mitochondrial function are rare in OA. Mitochondrial transfer from mesenchymal stem
Rui Wang, Talatibaike Maimaitijuma, Yuan-Yuan Ma, Yang Jiao, Yong-Ping Cao, Qiang Shi   +5 more
doaj   +1 more source

SPRY4 acts as an indicator of osteoarthritis severity and regulates chondrocyte hypertrophy and ECM protease expression

npj Regenerative Medicine, 2021
Osteoarthritis (OA) causes serious changes in the metabolic and signaling pathways of chondrocytes, including the mitogen-activated protein kinase (MAPK) pathway.
Sunghyun Park, Yoshie Arai, Alvin Bello, Hansoo Park, Dohyun Kim, Kyung-Soon Park, Soo-Hong Lee   +6 more
doaj   +1 more source

The potential of pulsed low intensity ultrasound to stimulate chondrocytes matrix synthesis in agarose and monolayer cultures [PDF]

, 2010
Pulsed low intensity ultrasound (PLIUS) has been used successfully for bone fracture repair and has therefore been suggested for cartilage regeneration.
Grainger, James, Grainger, J, Vaughan, NM, James Grainger, Bader, DL, Martin M. Knight, Dan L. Bader, Vaughan, Natalie M., Bader, Dan L., Knight, Martin M., Knight, MM, Natalie M. Vaughan   +11 more
core   +1 more source

Growth factors for clinical-scale expansion of human articular chondrocytes : Relevance for automated bioreactor systems [PDF]

, 2007
The expansion of chondrocytes in automated bioreactors for clinical use requires that a relevant number of cells be generated, starting from variable initial seeding densities in one passage and using autologous serum.
Candrian, Christian, Hagg, Rupert, Heberer, Michael, Martin, Ivan, Tommasini, Roberto, Barbero, Andrea, Francioli, Silvia-Elena, Sie, Christina-Priska   +7 more
core   +1 more source

Fibroblast Growth Factor 18 Increases the Trophic Effects of Bone Marrow Mesenchymal Stem Cells on Chondrocytes Isolated from Late Stage Osteoarthritic Patients

Stem Cells International, 2014
Coculture of mesenchymal stem cells with chondrocytes increases production of cartilaginous matrix. Chondrocytes isolated from late stage osteoarthritic patients usually lost their phenotype of producing cartilaginous matrix.
Zhenyu Zhang, Yan Wang, Mingchao Li, Jiaping Li, Jian Wu   +4 more
doaj   +1 more source