Results 41 to 50 of about 33,920 (248)

Expression patterns of chondrocyte genes cloned by differential display in tibial dyschondroplasia [PDF]

, 2000
Tibial dyschondroplasia (TD) appears to involve a failure of the growth plate chondrocytes within growing long bones to differentiate fully to the hypertrophic stage, resulting in a mass of prehypertrophic chondrocytes which form the avascular TD lesion.
Farquharson, C, Lester, D, Thorp, B H, Botman, M, Farquharson, C; id_orcid, Thorp, B.H, Jefferies, D, Whitehead, C.C, Houston, B, Whitehead, C C   +9 more
core   +1 more source

Immunological Response against Allogeneic Chondrocytes Transplanted into Joint Surface Defects in Rats

Cell Transplantation, 1997
Rat chondrocytes isolated from the articular–epiphyseal cartilage complex were transplanted into defects prepared in articular cartilage and subchondral bone. Transplants were taken for examination after 3 and 8 wk.
Anna Hyc, Jacek Malejczyk, Anna Osiecka, Stanislaw Moskalewski   +3 more
doaj   +1 more source

Differential cartilaginous tissue formation by human synovial membrane, fat pad, meniscus cells and articular chondrocytes [PDF]

, 2007
Objective: To identify an appropriate cell source for the generation of meniscus substitutes, among those which would be available by arthroscopy of injured knee joints.
A. Marsano, Jakob, M., I. Martin, E. Kon, Tognana, E., Nehrer, S., D.M. Salter, E. Tognana, Marsano, A., Adesida, A., Hardingham, T., Salter, D.M., S.J. Millward-Sadler, Salter, D. M., A. Adesida, S. Nehrer, T. Hardingham, Chiari-Grisar, C., Kon, E., Martin, I., Millward-Sadler, S. J., M. Jakob, C. Chiari-Grisar, Millward-Sadler, S.J.   +23 more
core   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Ozone induces autophagy by activating PPARγ/mTOR in rat chondrocytes treated with IL-1β

Journal of Orthopaedic Surgery and Research, 2022
Background Osteoarthritis (OA) is the main cause of older pain and disability. Intra-articular injections of ozone (O3) commonly have been found to have antioxidative and anti-inflammatory effects to reduce pain and improve function in knee ...
Panpan Sun, Weicheng Xu, Xu Zhao, Cong Zhang, Xiaowen Lin, Moxuan Gong, Zhijian Fu   +6 more
doaj   +1 more source

The chondrocyte primary cilium [PDF]

Osteoarthritis and Cartilage, 2014
The presence and role of primary, or non-motile, cilia on chondrocytes has confused cartilage researchers for decades. Initial explanations attributed a vestigial nature to chondrocyte cilia. Evidence is now emerging that supports the role of the chondrocyte primary cilium as a sensory organelle, in particular, in mechanotransduction and as a ...
Ruhlen, R., Marberry, K.
openaire   +2 more sources

DNA demethylation at specific CpG sites in the IL1B promoter in response to inflammatory cytokines in human articular chondrocytes

, 2009
Objective: to determine whether changes in the DNA methylation status in the promoter region of the gene encoding interleukin-1? (IL-1?) account for expression of IL1B mRNA after long-term treatment of human articular chondrocytes with inflammatory ...
Hashimoto, Ko, Gibson, Marc B., Helmtrud I. Roach, Mary B. Goldring, Richard O. C. Oreffo, Marc B. Gibson, Oreffo, Richard O.C., Roach, Helmstrud I., Goldring, Mary B., Ko Hashimoto   +9 more
core   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Effects of cell phenotype and seeding density on the chondrogenic capacity of human osteoarthritic chondrocytes in type I collagen scaffolds

Journal of Orthopaedic Surgery and Research, 2020
Objective Matrix-associated autologous chondrocyte implantation (MACI) achieves good clinical efficacy in young patients with focal cartilage injury; however, phenotypic de-differentiation of chondrocytes cultured in monolayer and the treatment of older ...
Chenxi Cao, Yujun Zhang, Yanqi Ye, Tiezheng Sun   +3 more
doaj   +1 more source

ATG5 regulates type Ⅱ collagen expression by modulation of autophagy

陆军军医大学学报, 2023
Objective To explore the regulative effect of autophagy-related protein ATG5 on the expression of type Ⅱ collagen in human chondrocytes through affecting autophagy function.
DENG Lin, XIAN Menglin, YANG Yuyou
doaj   +1 more source