Results 1 to 10 of about 118,173 (167)

The Role of Chondrocyte Hypertrophy and Senescence in Osteoarthritis Initiation and Progression

International Journal of Molecular Sciences, 2020
Osteoarthritis (OA) is the most common joint disease that causes pain and disability in the adult population. OA is primarily caused by trauma induced by an external force or by age-related cartilage damage.
Yeri Alice Rim, Ji Hyeon Ju, Yoojun Nam
exaly   +2 more sources

Yap1 Regulates Multiple Steps of Chondrocyte Differentiation during Skeletal Development and Bone Repair

Cell Reports, 2016
Hippo signaling controls organ size and tissue regeneration in many organs, but its roles in chondrocyte differentiation and bone repair remain elusive. Here, we demonstrate that Yap1, an effector of Hippo pathway inhibits skeletal development, postnatal
Yujie Deng, Ailing Wu, Pikshan Li, Gang Li, Ling Qin, Hai Song, Kinglun Kingston Mak   +6 more
doaj   +2 more sources

Biomarkers of Chondrocyte Apoptosis and Autophagy in Osteoarthritis

International Journal of Molecular Sciences, 2015
Cell death with morphological and molecular features of apoptosis has been detected in osteoarthritic (OA) cartilage, which suggests a key role for chondrocyte death/survival in the pathogenesis of OA.
Paola Castrogiovanni, Ali Mobasheri, Francesca Maria Trovato   +2 more
exaly   +2 more sources

Single-Cell RNA Sequencing Reveals the Difference in Human Normal and Degenerative Nucleus Pulposus Tissue Profiles and Cellular Interactions

Frontiers in Cell and Developmental Biology, 2022
Background: The nucleus pulposus is a constituent structure of the human intervertebral disc, and its degeneration can cause intervertebral disc degeneration (IDD).
Zhencong Li, Dongping Ye, Libing Dai, Yude Xu, Hao Wu, Wei Luo, Yiming Liu, Xiguan Yao, Peigeng Wang, Haixiong Miao, Jiake Xu, Weiguo Liang   +11 more
doaj   +1 more source

Three-dimensional (3D) hydrogel serves as a platform to identify potential markers of chondrocyte dedifferentiation by combining RNA sequencing

Bioactive Materials, 2021
Dedifferentiation of chondrocyte greatly restricts its function and application, however, it is poorly understood except a small number of canonical markers.
Yang Ling, Weiyuan Zhang, Peiyan Wang, Wanhua Xie, Wei Yang, Dong-An Wang, Changjiang Fan   +6 more
doaj   +1 more source

JNK-JUN-NCOA4 axis contributes to chondrocyte ferroptosis and aggravates osteoarthritis via ferritinophagy.

Free Radical Biology & Medicine, 2023
Interruption of iron homeostasis is correlated with cell ferroptosis and degenerative diseases. Nuclear receptor coactivator 4 (NCOA4)-mediated ferritinophagy has been reported as a vital mechanism to control cellular iron levels, but its impact on ...
Kai Sun, Liangcai Hou, Zhou Guo, Genchun Wang, Jiachao Guo, Jingxuan Xu, Xiong Zhang, Fengjing Guo   +7 more
semanticscholar   +1 more source

Deferoxamine Alleviates Osteoarthritis by Inhibiting Chondrocyte Ferroptosis and Activating the Nrf2 Pathway

Frontiers in Pharmacology, 2022
Objective: Osteoarthritis (OA) is a common disease with a complex pathology including mechanical load, inflammation, and metabolic factors. Chondrocyte ferroptosis contributes to OA progression.
Zhou Guo, Jiamin Lin, Kai Sun, Jiayou Guo, Xudong Yao, Genchun Wang, Liangcai Hou, Jingting Xu, Jiachao Guo, F. Guo   +9 more
semanticscholar   +1 more source

Chondrocyte-specific genomic editing enabled by hybrid exosomes for osteoarthritis treatment

Theranostics, 2022
Rationale: A cell-specific delivery vehicle is required to achieve gene editing of the disease-associated cells, so the hereditable genome editing reactions are confined within these cells without affecting healthy cells.
Yujie Liang, Xiao Xu, Limei Xu, Zoya Iqbal, O. Kan, Huawei Zhang, C. Wen, Lijuan Duan, Jiang Xia   +8 more
semanticscholar   +1 more source

The role of metabolism in chondrocyte dysfunction and the progression of osteoarthritis.

Ageing Research Reviews, 2020
Osteoarthritis (OA) is a degenerative joint disease characterized by low-grade inflammation and high levels of clinical heterogeneity. Aberrant chondrocyte metabolism is a response to changes in the inflammatory microenvironment and may play a key role ...
Linli Zheng, Ziji Zhang, P. Sheng, A. Mobasheri   +3 more
semanticscholar   +1 more source

Sirt6 attenuates chondrocyte senescence and osteoarthritis progression

Nature Communications, 2022
Sirt6 has been implicated as a key regulator in aging-related diseases, including osteoarthritis. However, its functional role and molecular mechanism in chondrocyte senescence and osteoarthritis pathophysiology remain largely undefined.
M. Ji, Hua Jiang, Zhuang Li, Rui Geng, Jun-Zheng Hu, Yu Cheng Lin, Jun Lu   +6 more
semanticscholar   +1 more source