Results 1 to 10 of about 70,223 (315)
A Preliminary Study of Human Amniotic Membrane as a Potential Chondrocyte Carrier [PDF]
Malaysian Orthopaedic Journal, 2009 PURPOSE: To investigate the feasibility of using processed human amniotic membrane (HAM) to support the attachment and proliferation of chondrocytes in vitro which in turn can be utilised as a cell delivery vehicle in tissue engineering applications.
L Boo +5 more
doaj +2 more sources
Mechanisms of chondrocyte apoptosis
Osteoarthritis and Cartilage, 1999 This study addresses the occurrence and significance of chondrocyte apoptosis in the pathogenesis of cartilage destruction. Chondrocyte apoptosis can be inducedin vitroby nitric oxide donors, but not by pro-inflammatory cytokines, such as IL-1 or TNF.
Lotz, M., Hashimoto, S., Kühn, K.
core +3 more sources
Frontiers in Cell and Developmental Biology, 2022 Background: The nucleus pulposus is a constituent structure of the human intervertebral disc, and its degeneration can cause intervertebral disc degeneration (IDD).
Zhencong Li +11 more
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Bioactive Materials, 2021 Dedifferentiation of chondrocyte greatly restricts its function and application, however, it is poorly understood except a small number of canonical markers.
Yang Ling +6 more
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The hypertrophic chondrocyte: To be or not to be.
Histology and histopathology, 2021 Hypertrophic chondrocytes are the master regulators of endochondral ossification; however, their ultimate cell fates cells remain largely elusive due to their transient nature. Historically, hypertrophic chondrocytes have been considered as the terminal state of growth plate chondrocytes, which are destined to meet their inevitable demise at the ...
Hallett, Shawn A. +2 more
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Functional Duality of Chondrocyte Hypertrophy and Biomedical Application Trends in Osteoarthritis
Pharmaceutics, 2021 Chondrocyte hypertrophy is one of the key indicators in the progression of osteoarthritis (OA). However, compared with other OA indications, such as cartilage collapse, sclerosis, inflammation, and protease activation, the mechanisms by which chondrocyte
Sunghyun Park +8 more
doaj +1 more source
The emerging chondrocyte channelome [PDF]
Frontiers in Physiology, 2010 Chondrocytes are the resident cells of articular cartilage and are responsible for synthesizing a range of collagenous and non-collagenous extracellular matrix macromolecules. Whilst chondrocytes exist at low densities in the tissue (1-10% of the total tissue volume in mature cartilage) they are extremely active cells and are capable of responding to a
Barrett-Jolley, R +3 more
openaire +5 more sources
Stem Cells Translational Medicine, 2020 Chondrocyte hypertrophy‐like change is an important pathological process of osteoarthritis (OA), but the mechanism remains largely unknown. Neural cell adhesion molecule (NCAM) is highly expressed and involved in the chondrocyte differentiation of ...
Bin‐Feng Cheng +9 more
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Physiological Reports, 2020 Prolonging chondrocyte survival is essential to ensure fresh osteochondral (OC) grafts for treatment of articular cartilage lesions. Doxycycline has been shown to enhance cartilage growth, disrupt terminal differentiation of chondrocytes, and inhibit ...
Li Yue +3 more
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Characterisation of Growth Plate Dynamics in Murine Models of Osteoarthritis
Frontiers in Endocrinology, 2021 The purpose of this study was to investigate growth plate dynamics in surgical and loading murine models of osteoarthritis, to understand whether abnormalities in these dynamics are associated with osteoarthritis development. 8-week-old C57BL/6 male mice
Hasmik J. Samvelyan +8 more
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