Results 1 to 10 of about 76,519 (202)
Frontiers in Cell and Developmental Biology, 2022 Background: The nucleus pulposus is a constituent structure of the human intervertebral disc, and its degeneration can cause intervertebral disc degeneration (IDD).
Zhencong Li +11 more
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Bioactive Materials, 2021 Dedifferentiation of chondrocyte greatly restricts its function and application, however, it is poorly understood except a small number of canonical markers.
Yang Ling +6 more
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Functional Duality of Chondrocyte Hypertrophy and Biomedical Application Trends in Osteoarthritis
Pharmaceutics, 2021 Chondrocyte hypertrophy is one of the key indicators in the progression of osteoarthritis (OA). However, compared with other OA indications, such as cartilage collapse, sclerosis, inflammation, and protease activation, the mechanisms by which chondrocyte
Sunghyun Park +8 more
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Stem Cells Translational Medicine, 2020 Chondrocyte hypertrophy‐like change is an important pathological process of osteoarthritis (OA), but the mechanism remains largely unknown. Neural cell adhesion molecule (NCAM) is highly expressed and involved in the chondrocyte differentiation of ...
Bin‐Feng Cheng +9 more
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Physiological Reports, 2020 Prolonging chondrocyte survival is essential to ensure fresh osteochondral (OC) grafts for treatment of articular cartilage lesions. Doxycycline has been shown to enhance cartilage growth, disrupt terminal differentiation of chondrocytes, and inhibit ...
Li Yue +3 more
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Characterisation of Growth Plate Dynamics in Murine Models of Osteoarthritis
Frontiers in Endocrinology, 2021 The purpose of this study was to investigate growth plate dynamics in surgical and loading murine models of osteoarthritis, to understand whether abnormalities in these dynamics are associated with osteoarthritis development. 8-week-old C57BL/6 male mice
Hasmik J. Samvelyan +8 more
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Chondrocytes in the resting zone of the growth plate are maintained in a Wnt-inhibitory environment
eLife, 2021 Chondrocytes in the resting zone of the postnatal growth plate are characterized by slow cell cycle progression, and encompass a population of parathyroid hormone-related protein (PTHrP)-expressing skeletal stem cells that contribute to the formation of ...
Shawn A Hallett +10 more
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Development of Anti-OSCAR Antibodies for the Treatment of Osteoarthritis
Biomedicines, 2023 Osteoarthritis (OA) is the most common joint disease that causes local inflammation and pain, significantly reducing the quality of life and normal social activities of patients.
Gyeong Min Kim +8 more
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The scinderin gene (SCIN) is the direct target of miR3085-3p in chondrocytes [PDF]
Archives of Biological Sciences, 2020 MiR-3085-3p was shown to play a crucial role in cartilage biology, with potential impacts in osteoarthritis (OA). Insight into this miRNA function could be of practical importance for future miRNA-based therapy, however, little is known regarding the ...
Le Linh T.T. +2 more
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Ochronotic Chondropathy: A Case Report
Biomedicines, 2023 Endogenous ochronosis, also known as alkaptonuria, is a rare disease known for its bluish-black discoloration of the skin, sclerae, and pinnae, as well as urine that turns black upon standing.
Jake Littman +4 more
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