Patient-oriented and performance-based outcomes after knee autologous chondrocyte implantation: a timeline for the first year of recovery [PDF]
, 2014 It is well established that autologous chondrocyte implantation (ACI) can require extended recovery postoperatively; however, little information exists to provide clinicians and patients with a timeline for anticipated function during the first year ...
English, R. A. +4 more
core +1 more source
Chondrocytes in the resting zone of the growth plate are maintained in a Wnt-inhibitory environment
eLife, 2021 Chondrocytes in the resting zone of the postnatal growth plate are characterized by slow cell cycle progression, and encompass a population of parathyroid hormone-related protein (PTHrP)-expressing skeletal stem cells that contribute to the formation of ...
Shawn A Hallett +10 more
doaj +1 more source
Distinct metabolic programs induced by TGF-β1 and BMP2 in human articular chondrocytes with osteoarthritis [PDF]
, 2018 Objectives: Cellular energy metabolism is important for the function of all tissues, including cartilage. Recent studies indicate that superficial and deep subpopulations of articular chondrocytes (ACs) have distinct metabolic profiles.
O\u27Keefe, Regis J +3 more
core +3 more sources
Global Gene Expression Analysis Identifies Age-Related Differences in Knee Joint Transcriptome during the Development of Post-Traumatic Osteoarthritis in Mice. [PDF]
, 2020 Aging and injury are two major risk factors for osteoarthritis (OA). Yet, very little is known about how aging and injury interact and contribute to OA pathogenesis.
Christiansen, Blaine A +7 more
core +2 more sources
Effect of age and cytoskeletal elements on the indentation-dependent mechanical properties of chondrocytes. [PDF]
, 2013 Articular cartilage chondrocytes are responsible for the synthesis, maintenance, and turnover of the extracellular matrix, metabolic processes that contribute to the mechanical properties of these cells.
Blanchette, Craig +5 more
core +2 more sources
Development of Anti-OSCAR Antibodies for the Treatment of Osteoarthritis
Biomedicines, 2023 Osteoarthritis (OA) is the most common joint disease that causes local inflammation and pain, significantly reducing the quality of life and normal social activities of patients.
Gyeong Min Kim +8 more
doaj +1 more source
The scinderin gene (SCIN) is the direct target of miR3085-3p in chondrocytes [PDF]
Archives of Biological Sciences, 2020 MiR-3085-3p was shown to play a crucial role in cartilage biology, with potential impacts in osteoarthritis (OA). Insight into this miRNA function could be of practical importance for future miRNA-based therapy, however, little is known regarding the ...
Le Linh T.T. +2 more
doaj +1 more source
Ochronotic Chondropathy: A Case Report
Biomedicines, 2023 Endogenous ochronosis, also known as alkaptonuria, is a rare disease known for its bluish-black discoloration of the skin, sclerae, and pinnae, as well as urine that turns black upon standing.
Jake Littman +4 more
doaj +1 more source
Use of autologous adipose-derived mesenchymal stem cells for creation of laryngeal cartilage [PDF]
, 2017 OBJECTIVES/HYPOTHESIS: Adipose-derived mesenchymal stem cells (ASCs) are an exciting potential cell source for tissue engineering because cells can be derived from the simple excision of autologous fat.
Brookes, Sarah +6 more
core +1 more source
Artificial Cells, Nanomedicine, and Biotechnology, 2019 The medical community has expressed significant interest in the treatment of cartilage defect. Successful repair of articular cartilage defects remains a challenge in clinics. Due to the huge advantages of 3D micro/nanomaterials, 3D artificial micro/nano
Shuai Wu +8 more
doaj +1 more source