Results 11 to 20 of about 118,322 (313)

The hypertrophic chondrocyte: To be or not to be.

Histology and histopathology, 2021
Hypertrophic chondrocytes are the master regulators of endochondral ossification; however, their ultimate cell fates cells remain largely elusive due to their transient nature. Historically, hypertrophic chondrocytes have been considered as the terminal state of growth plate chondrocytes, which are destined to meet their inevitable demise at the ...
Hallett, Shawn A., Ono, Wanida, Ono, Noriaki   +2 more
openaire   +2 more sources

Single cell RNA-seq analysis identifies ferroptotic chondrocyte cluster and reveals TRPV1 as an anti-ferroptotic target in osteoarthritis

EBioMedicine, 2022
Summary Background Osteoarthritis (OA) is the most common degenerative joint disease primarily characterized by cartilage destruction. The aim of this study was to investigate the role, molecular characteristics and potential therapeutic target of ...
Z. Lv, Jie Han, Jiawei Li, Hu Guo, Yuxiang Fei, Zi-ying Sun, Jian Dong, Maochun Wang, Chun-mei Fan, Weitong Li, Yanzheng Xie, Weibang Sun, Jiaqi Chen, Yuan Liu, Fufei Chen, Zizheng Liu, Anlong Liu, Rui Wu, Xingquan Xu, Wenjin Yan, Q. Jiang, S. Ikegawa, Xiao Chen, D. Shi   +23 more
semanticscholar   +1 more source

TRPM7 channel inhibition attenuates rheumatoid arthritis articular chondrocyte ferroptosis by suppression of the PKCα-NOX4 axis

Redox Biology, 2022
A role for ferroptosis in articular cartilage destruction associated with rheumatoid arthritis (RA) has not been identified. We previously reported transient receptor potential melastatin 7 (TRPM7) expression was correlated with RA cartilage destruction.
Renpeng Zhou, Yong Chen, Shu-fang Li, Xin Wei, Wei Hu, Su’an Tang, Jie Ding, Wanjin Fu, Hailin Zhang, Fan Chen, Wenjuan Hao, Yi Lin, Rendi Zhu, Ke Wang, Lei Dong, Yingjie Zhao, Xiaowen Feng, Feihu Chen, C. Ding, Wei Hu   +19 more
semanticscholar   +1 more source

Functional Duality of Chondrocyte Hypertrophy and Biomedical Application Trends in Osteoarthritis

Pharmaceutics, 2021
Chondrocyte hypertrophy is one of the key indicators in the progression of osteoarthritis (OA). However, compared with other OA indications, such as cartilage collapse, sclerosis, inflammation, and protease activation, the mechanisms by which chondrocyte
Sunghyun Park, Alvin Bello, Yoshie Arai, Jinsung Ahn, Dohyun Kim, Kyung-Yup Cha, Inho Baek, Hansoo Park, Soo-Hong Lee   +8 more
doaj   +1 more source

SOX9 keeps growth plates and articular cartilage healthy by inhibiting chondrocyte dedifferentiation/osteoblastic redifferentiation

Proceedings of the National Academy of Sciences of the United States of America, 2021
Significance Cartilage is essential in vertebrate development and adulthood. Cartilage growth plates ensure skeletal growth until closing at puberty, and articular cartilage ensures lifelong structural and functional integrity of joints.
A. Haseeb, R. Kc, M. Angelozzi, Charles de Charleroy, D. Rux, R. Tower, L. Yao, Renata Pellegrino da Silva, M. Pacifici, L. Qin, V. Lefebvre   +10 more
semanticscholar   +1 more source

Molecular Mechanisms of Chondrocyte Proliferation and Differentiation

Frontiers in Cell and Developmental Biology, 2021
Cartilage is a kind of connective tissue that buffers pressure and is essential to protect joint movement. It is difficult to self-recover once cartilage is damaged due to the lack of blood vessels, lymph, and nerve tissues. Repair of cartilage injury is
Hui Chen, Xiaofeng Tan, Shiaw-Guang Hu, Renhui Liu, Li-Hong Peng, Yongmin Li, Ping Wu   +6 more
semanticscholar   +1 more source

D‐mannose alleviates osteoarthritis progression by inhibiting chondrocyte ferroptosis in a HIF‐2α‐dependent manner

Cell Proliferation, 2021
Chondrocyte ferroptosis contributes to osteoarthritis (OA) progression, and D‐mannose shows therapeutic value in many inflammatory conditions. Here, we investigated whether D‐mannose interferes in chondrocyte ferroptotic cell death during osteoarthritic ...
X. Zhou, Yingcheng Zheng, Wentian Sun, Zhenzhen Zhang, Jiaqi Liu, Wenke Yang, Wenxiu Yuan, Y. Yi, Jun Wang, Jin Liu   +9 more
semanticscholar   +1 more source

The emerging chondrocyte channelome [PDF]

Frontiers in Physiology, 2010
Chondrocytes are the resident cells of articular cartilage and are responsible for synthesizing a range of collagenous and non-collagenous extracellular matrix macromolecules. Whilst chondrocytes exist at low densities in the tissue (1-10% of the total tissue volume in mature cartilage) they are extremely active cells and are capable of responding to a
Barrett-Jolley, R, Lewis, R, Fallman, R, Mobasheri, A   +3 more
openaire   +5 more sources

Neural cell adhesion molecule regulates chondrocyte hypertrophy in chondrogenic differentiation and experimental osteoarthritis

Stem Cells Translational Medicine, 2020
Chondrocyte hypertrophy‐like change is an important pathological process of osteoarthritis (OA), but the mechanism remains largely unknown. Neural cell adhesion molecule (NCAM) is highly expressed and involved in the chondrocyte differentiation of ...
Bin‐Feng Cheng, Jun‐Jiang Lian, Hai‐Jie Yang, Lei Wang, Hao‐Heng Yu, Jia‐Jia Bi, Yao‐Xin Gao, Su‐Juan Chen, Mian Wang, Zhi‐Wei Feng   +9 more
doaj   +1 more source

Chondrocyte ferroptosis contribute to the progression of osteoarthritis

Journal of Orthopaedic Translation, 2020
Summary Background Osteoarthritis (OA) is a complex process comprised of mechanical load, inflammation, and metabolic factors. It is still unknown that if chondrocytes undergo ferroptosis during OA and if ferroptosis contribute to the progression of OA ...
Xudong Yao, Kai Sun, Shengnan Yu, Jia-hui Luo, Jiachao Guo, Jiamin Lin, Genchun Wang, Zhou Guo, Yaping Ye, Fengjing Guo   +9 more
semanticscholar   +1 more source