Results 11 to 20 of about 70,223 (315)

The Incidence and Clinical Relevance of Graft Hypertrophy After Matrix-Based Autologous Chondrocyte Implantation [PDF]

, 2011
Background: Graft hypertrophy is the most common complication of periosteal autologous chondrocyte implantation (p-ACI). Purpose: The aim of this prospective study was to analyze the development, the incidence rate, and the persistence of graft ...
Matthias F. Pietschmann, Isa Feist-Pagenstert, Peter E. Müller, Volkmar Jansson, Horng, Annie, Müller, Peter E., Thomas R. Niethammer, Feist-Pagenstert, Isa, Jansson, Volkmar, Mehmet F. Gülecyüz, Pietschmann, Matthias F., Niethammer, Thomas R., Gülecyüz, Mehmet F., Annie Horng   +13 more
core   +1 more source

Depletion of chondrocyte primary cilia reduces the compressive modulus of articular cartilage [PDF]

, 2014
Primary cilia are slender, microtubule based structures found in the majority of cell types with one cilium per cell. In articular cartilage, primary cilia are required for chondrocyte mechanotransduction and the development of healthy tissue.
Ramaswamy, G, Ramaswamy, Girish, Irianto, J, Serra, Rosa, Knight, MM, Knight, Martin M., Serra, R, Irianto, Jerome   +7 more
core   +1 more source

Chondrocytes in the resting zone of the growth plate are maintained in a Wnt-inhibitory environment

eLife, 2021
Chondrocytes in the resting zone of the postnatal growth plate are characterized by slow cell cycle progression, and encompass a population of parathyroid hormone-related protein (PTHrP)-expressing skeletal stem cells that contribute to the formation of ...
Shawn A Hallett, Yuki Matsushita, Wanida Ono, Naoko Sakagami, Koji Mizuhashi, Nicha Tokavanich, Mizuki Nagata, Annabelle Zhou, Takao Hirai, Henry M Kronenberg, Noriaki Ono   +10 more
doaj   +1 more source

Biomechanical signals and the C-type natriuretic peptide counteract catabolic activities induced by IL-1? in chondrocyte/agarose constructs [PDF]

, 2011
Introduction: The present study examined the effect of C-type natriuretic peptide (CNP) on the anabolic and catabolic activities in chondrocyte/agarose constructs subjected to dynamic compression.
Achan, P., Chowdhury, T.T., Salter, Donald M, Ramachandran, Manoj, Salter, DM, Chowdhury, TT, Ramachandran, M., Ramachandran, M, Dan L Bader, Achan, Prim, Salter, D.M., Tina T Chowdhury, Bader, Dan L, Bader, DL, Prim Achan, Donald M Salter, Chowdhury, Tina T, Bader, Dan L., Manoj Ramachandran, Achan, P   +19 more
core   +1 more source

Development of Anti-OSCAR Antibodies for the Treatment of Osteoarthritis

Biomedicines, 2023
Osteoarthritis (OA) is the most common joint disease that causes local inflammation and pain, significantly reducing the quality of life and normal social activities of patients.
Gyeong Min Kim, Doo Ri Park, Thi Thu Ha Nguyen, Jiseon Kim, Jihee Kim, Myung-Ho Sohn, Won-Kyu Lee, Soo Young Lee, Hyunbo Shim   +8 more
doaj   +1 more source

The scinderin gene (SCIN) is the direct target of miR3085-3p in chondrocytes [PDF]

Archives of Biological Sciences, 2020
MiR-3085-3p was shown to play a crucial role in cartilage biology, with potential impacts in osteoarthritis (OA). Insight into this miRNA function could be of practical importance for future miRNA-based therapy, however, little is known regarding the ...
Le Linh T.T., Ho Phuong T.B., Clark Ian M.   +2 more
doaj   +1 more source

Ochronotic Chondropathy: A Case Report

Biomedicines, 2023
Endogenous ochronosis, also known as alkaptonuria, is a rare disease known for its bluish-black discoloration of the skin, sclerae, and pinnae, as well as urine that turns black upon standing.
Jake Littman, John Pietro, Jon Olansen, Chanika Phornphutkul, Roy K. Aaron   +4 more
doaj   +1 more source

Clinical and cost-effectiveness of autologous chondrocyte implantation for cartilage defects in knee joints : systematic review and economic evaluation [PDF]

, 2005
Objective: To support a review of the guidance issued by the National Institute for Health and Clinical Excellence (NICE) in December 2000 by examining the current clinical and cost-effectiveness evidence on autologous cartilage transplantation ...
C Clar, P Jobanputra, N Waugh, Lamb, J. (John D.), Clar, C., Bain, L. (Lynda), Jobanputra, Paresh, L Bain, McIntyre, Linda, J Lamb, Cummins, E. (Ewen), E Cummins, L McIntyre, Waugh, Norman, Thomas, Sian, S Thomas   +15 more
core   +1 more source

Increase in NO causes osteoarthritis and chondrocyte apoptosis and chondrocyte ERK plays a protective role in the process

, 2021
BACKGROUND: Nitric oxide (NO) and reactive oxygen species (ROS) play an important role in the pathology of human osteoarthritis (OA). Ankylosing spondylitis (AS) and atypical OA have similar clinical manifestations and often require differential ...
Chen, Qun, Kao, Xibin, Chen, Chen, Gao, Yan, Dong, Zhaoheng, Chen, Jinghong   +5 more
core   +1 more source

Allogenic chondrocyte/osteoblast-loaded β-tricalcium phosphate bioceramic scaffolds for articular cartilage defect treatment

Artificial Cells, Nanomedicine, and Biotechnology, 2019
The medical community has expressed significant interest in the treatment of cartilage defect. Successful repair of articular cartilage defects remains a challenge in clinics. Due to the huge advantages of 3D micro/nanomaterials, 3D artificial micro/nano
Shuai Wu, Zhiguo Kai, Dong Wang, Lina Tao, Peng Zhang, Dawei Wang, Dongxing Liu, Shui Sun, Jian Zhong   +8 more
doaj   +1 more source