Results 31 to 40 of about 118,322 (313)
Artificial Cells, Nanomedicine, and Biotechnology, 2019 The medical community has expressed significant interest in the treatment of cartilage defect. Successful repair of articular cartilage defects remains a challenge in clinics. Due to the huge advantages of 3D micro/nanomaterials, 3D artificial micro/nano
Shuai Wu +8 more
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Biomedicines, 2023 In osteoarthritis (OA), the articular cartilage covering the articular surface of the bone wears out, exposing the subchondral bone, and the synovial membrane surrounding the joint becomes inflamed, causing pain and deformity.
Hun Hwan Kim +11 more
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Metaplasia of Chondrocytes into Osteoblasts
Folia Biologica, 2006 Hypertrophic chondrocytes, commonly considered as terminal cells responsible for apoptotic elimination in endochondral osteogenesis, have the potential to switch their metabolic role and enter osteoblastic differentiation, based on histochemical, immunohistochemical, biochemical and cytological analysis.
Krzysztof H, Włodarski +2 more
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Autoimmunity, 2021 Long non-coding RNAs (lncRNAs) play a part in a wide variety of diseases, including osteoarthritis (OA). This study was designed to investigate the biological role of lncRNA LINC00265 in OA and its underlying mechanisms.
Hanlin Zou, Chunde Lu, Jianjun Qiu
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CircSCAPER contributes to IL-1β-induced osteoarthritis in vitro via miR-140-3p/EZH2 axis
Bone & Joint Research, 2022 Aims Circular RNA (circRNA) S-phase cyclin A-associated protein in the endoplasmic reticulum (ER) (circSCAPER, ID: hsa_circ_0104595) has been found to be highly expressed in osteoarthritis (OA) patients and has been associated with the severity of OA ...
Zhaxi Luobu +5 more
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Antioxidants, 2020 Compromised autophagy and mitochondrial dysfunction downregulate chondrocytic activity, accelerating the development of osteoarthritis (OA). Irisin, a cleaved form of fibronectin type III domain containing 5 (FNDC5), regulates bone turnover and muscle ...
Feng-Sheng Wang +12 more
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The Elusive Origin of Atherosclerotic Plaque Calcification
Frontiers in Cell and Developmental Biology, 2021 It has been known for decades or even centuries that arteries calcify as they age. Vascular calcification probably affects all adults, since virtually all have atherosclerotic plaques: an accumulation of lipids, inflammatory cells, necrotic debris, and ...
Emmanuelle Canet-Soulas +4 more
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Glutamine Metabolism Controls Chondrocyte Identity and Function.
Developmental Cell, 2020 Correct functioning of chondrocytes is crucial for long bone growth and fracture repair. These cells are highly anabolic but survive and function in an avascular environment, implying specific metabolic requirements that are, however, poorly ...
Steve Stegen +8 more
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Optimization of Sturgeon Cartilage Products and Its Regulation on Human Chondrocyte Inflammation
Shipin gongye ke-ji, 2022 The purpose of this paper was to prepare a sturgeon cartilage product from sturgeon cartilage and explore its effect on inflammation of human chondrocytes.
Hengge LIU +6 more
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Nav1.7 as a chondrocyte regulator and therapeutic target for osteoarthritis
NatureOsteoarthritis (OA) is the most common joint disease. Currently there are no effective methods that simultaneously prevent joint degeneration and reduce pain1.
W. Fu +26 more
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