Results 31 to 40 of about 97,625 (307)
Antioxidants, 2020 Compromised autophagy and mitochondrial dysfunction downregulate chondrocytic activity, accelerating the development of osteoarthritis (OA). Irisin, a cleaved form of fibronectin type III domain containing 5 (FNDC5), regulates bone turnover and muscle ...
Feng-Sheng Wang +12 more
doaj +1 more source
ADAM15 modulates outside-in signalling in chondrocyte–matrix interactions [PDF]
, 2008 ADAM15 belongs to a family of transmembrane multi-domain proteins implicated in proteolysis, cell–cell and cell–matrix interactions in various disease conditions.
Burkhardt, Harald +2 more
core +1 more source
The emerging chondrocyte channelome [PDF]
Frontiers in Physiology, 2010 Chondrocytes are the resident cells of articular cartilage and are responsible for synthesizing a range of collagenous and non-collagenous extracellular matrix macromolecules. Whilst chondrocytes exist at low densities in the tissue (1-10% of the total tissue volume in mature cartilage) they are extremely active cells and are capable of responding to a
Barrett-Jolley, R +3 more
openaire +5 more sources
The role of changes in extracellular matrix of cartilage in the presence of inflammation on the pathology of osteoarthritis. [PDF]
, 2013 Osteoarthritis (OA) is a degenerative disease that affects various tissues surrounding joints such as articular cartilage, subchondral bone, synovial membrane, and ligaments.
Maldonado, Maricela, Nam, Jin
core +3 more sources
The Elusive Origin of Atherosclerotic Plaque Calcification
Frontiers in Cell and Developmental Biology, 2021 It has been known for decades or even centuries that arteries calcify as they age. Vascular calcification probably affects all adults, since virtually all have atherosclerotic plaques: an accumulation of lipids, inflammatory cells, necrotic debris, and ...
Emmanuelle Canet-Soulas +4 more
doaj +1 more source
Optimization of Sturgeon Cartilage Products and Its Regulation on Human Chondrocyte Inflammation
Shipin gongye ke-ji, 2022 The purpose of this paper was to prepare a sturgeon cartilage product from sturgeon cartilage and explore its effect on inflammation of human chondrocytes.
Hengge LIU +6 more
doaj +1 more source
Growth factors for clinical-scale expansion of human articular chondrocytes : Relevance for automated bioreactor systems [PDF]
, 2007 The expansion of chondrocytes in automated bioreactors for clinical use requires that a relevant number of cells be generated, starting from variable initial seeding densities in one passage and using autologous serum.
Andrea Barbero +12 more
core +1 more source
Immunogenicity of chondrocyte sheets: a review
Frontiers in ImmunologyThe chondrocyte sheet is a sheet-like cell structure obtained by separating in vitro expanded and fused autologous chondrocytes from the bottom of the culture dish by physical means.
Juncen Li +21 more
doaj +1 more source
Frontiers in Pharmacology, 2021 Osteoarthritis (OA) is the most prevalent joint disease worldwide, making it a major cause of pain and disability. Identified as a chronic and progressive disease, effective treatment at the early stages of OA has become critical to its management ...
Chenyang Zhuang +6 more
doaj +1 more source
Post-traumatic osteoarthritis in mice following mechanical injury to the synovial joint [PDF]
, 2017 We investigated the spectrum of lesions characteristic of post-traumatic osteoarthritis (PTOA) across the knee joint in response to mechanical injury.
Chinzei, Nobuaki +7 more
core +3 more sources