Results 51 to 60 of about 118,322 (313)

Single-cell RNA sequencing reveals different chondrocyte states in femoral cartilage between osteoarthritis and healthy individuals

Frontiers in Immunology
BackgroundCartilage injury is the main pathological manifestation of osteoarthritis (OA). Healthy chondrocyte is a prerequisite for cartilage regeneration and repair.
Zewen Sun, Zewen Sun, Mingyue Yan, Mingyue Yan, Junjie Wang, Junjie Wang, Haoyun Zhang, Xiaobin Ji, Yujing Xiao, Tianrui Wang, Tianrui Wang, Tengbo Yu, Tengbo Yu   +12 more
doaj   +1 more source

PKR Promotes Oxidative Stress and Apoptosis of Human Articular Chondrocytes by Causing Mitochondrial Dysfunction through p38 MAPK Activation—PKR Activation Causes Apoptosis in Human Chondrocytes

Antioxidants, 2019
Osteoarthritis (OA) is one of the most common types of arthritis in the elderly people. It has been known that chondrocyte apoptosis occurs in OA cartilage; however, the detailed molecular mechanism remains unclear.
Ching-Hou Ma, Chin-Hsien Wu, I-Ming Jou, Yuan-Kun Tu, Ching-Hsia Hung, Wan-Ching Chou, Yun-Ching Chang, Pei-Ling Hsieh, Kun-Ling Tsai   +8 more
doaj   +1 more source

Glycolytic enzyme PKM2 regulates cell senescence but not inflammation in the process of osteoarthritis

Acta Biochimica et Biophysica Sinica, 2023
Chondrocyte senescence is an important mechanism underlying osteoarthritis in the senile population and is characterized by reduced expressions of the extracellular matrix proteins. The involvement of glycolysis
Liu Bo, Wang Chenzhong, Weng Ziyu, Yang Yi, Zhao Hong, Zhang Yueqi, Fei Qinming, Shi Yi, Zhang Chi   +8 more
doaj   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Experimental Therapeutics for the Treatment of Osteoarthritis

Journal of Experimental Pharmacology, 2021
Gundula Schulze-Tanzil Department of Anatomy and Cell Biology, Paracelsus Medical University, Nuremberg, Bavaria, GermanyCorrespondence: Gundula Schulze-Tanzil Email gundula.schulze@pmu.ac.atAbstract: Osteoarthritis (OA) therapy remains a large challenge
Schulze-Tanzil G
doaj  

Regulation of MMP-3 expression and secretion by the chemokine eotaxin-1 in human chondrocytes

Journal of Biomedical Science, 2011
Background Osteoarthritis (OA) is characterized by the degradation of articular cartilage, marked by the breakdown of matrix proteins. Studies demonstrated the involvement of chemokines in this process, and some may potentially serve as diagnostic ...
Chao Pin-Zhir, Hsieh Ming-Shium, Cheng Chao-Wen, Lin Yung-Feng, Chen Chien-Ho   +4 more
doaj   +1 more source

Lack of Skeletal Effects in Mice with Targeted Disruptionof Prolyl Hydroxylase Domain 1 (Phd1) Gene Expressed in Chondrocytes

Life, 2022
The critical importance of hypoxia-inducible factor (HIF)s in the regulation of endochondral bone formation is now well established. HIF protein levels are closely regulated by the prolyl hydroxylase domain-containing protein (PHD) mediated ubiquitin ...
Weirong Xing, Destiney Larkin, Sheila Pourteymoor, William Tambunan, Gustavo A. Gomez, Elaine K. Liu, Subburaman Mohan   +6 more
doaj   +1 more source

The Role of Chondrocyte Morphology and Volume in Controlling Phenotype—Implications for Osteoarthritis, Cartilage Repair, and Cartilage Engineering

Current Rheumatology Reports, 2019
Purpose of ReviewArticular chondrocytes are exclusively responsible for the turnover of the extracellular matrix (ECM) of hyaline cartilage. However, chondrocytes are phenotypically unstable and, if they de-differentiate into hypertrophic or fibroblastic
A. Hall
semanticscholar   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Ameliorative Effects of Cardamonin on Monosodium Urate-Induced Gouty Arthritis through Inhibiting NLRP3 Inflammasome Mediation

Medicina, 2021
Background and Objectives: Gouty arthritis is an acute inflammatory response caused by the precipitation of monosodium urate (MSU) crystals in joints. The triggering of MSU leads to increased production of inflammatory cytokines, such as interleukin-1β ...
Chih-Chien Wang, Jeng-Wei Lu, Yi-Jen Peng, Chian-Her Lee, Herng-Sheng Lee, You-Hsiang Chu, Chun-Jung Huang, Yi-Jung Ho, Feng-Cheng Liu, Chia-Chun Wu   +9 more
doaj   +1 more source