Results 51 to 60 of about 97,625 (307)

Role of galectin-3 in bone cell differentiation, bone pathophysiology and vascular osteogenesis [PDF]

, 2017
Galectin-3 is expressed in various tissues, including the bone, where it is considered a marker of chondrogenic and osteogenic cell lineages. Galectin-3 protein was found to be increased in the differentiated chondrocytes of the metaphyseal plate ...
Fantauzzi, Claudia Blasetti, Iacobini, Carla, Menini, Stefano, Pugliese, Giuseppe   +3 more
core   +2 more sources

Associations of Sleep and Shift Work With Osteoarthritis Risk

Arthritis Care &Research, EarlyView.
Objective Daily rhythms may be critical for maintaining homeostasis of joint tissues. We aimed to investigate the relationships among circadian clock disruption, sleep, and osteoarthritis (OA) risk in humans. Methods In the UK Biobank, a prospective 500,000–person cohort, we evaluated associations among sleep duration, sleeplessness/insomnia, and shift
Elizabeth L. Yanik, Abigail Bridgeman, Erik D. Herzog, Vy Pham, Bradley A. Evanoff, Farshid Guilak   +5 more
wiley   +1 more source

Single-cell RNA sequencing reveals different chondrocyte states in femoral cartilage between osteoarthritis and healthy individuals

Frontiers in Immunology
BackgroundCartilage injury is the main pathological manifestation of osteoarthritis (OA). Healthy chondrocyte is a prerequisite for cartilage regeneration and repair.
Zewen Sun, Zewen Sun, Mingyue Yan, Mingyue Yan, Junjie Wang, Junjie Wang, Haoyun Zhang, Xiaobin Ji, Yujing Xiao, Tianrui Wang, Tianrui Wang, Tengbo Yu, Tengbo Yu   +12 more
doaj   +1 more source

PKR Promotes Oxidative Stress and Apoptosis of Human Articular Chondrocytes by Causing Mitochondrial Dysfunction through p38 MAPK Activation—PKR Activation Causes Apoptosis in Human Chondrocytes

Antioxidants, 2019
Osteoarthritis (OA) is one of the most common types of arthritis in the elderly people. It has been known that chondrocyte apoptosis occurs in OA cartilage; however, the detailed molecular mechanism remains unclear.
Ching-Hou Ma, Chin-Hsien Wu, I-Ming Jou, Yuan-Kun Tu, Ching-Hsia Hung, Wan-Ching Chou, Yun-Ching Chang, Pei-Ling Hsieh, Kun-Ling Tsai   +8 more
doaj   +1 more source

Glycolytic enzyme PKM2 regulates cell senescence but not inflammation in the process of osteoarthritis

Acta Biochimica et Biophysica Sinica, 2023
Chondrocyte senescence is an important mechanism underlying osteoarthritis in the senile population and is characterized by reduced expressions of the extracellular matrix proteins. The involvement of glycolysis
Liu Bo, Wang Chenzhong, Weng Ziyu, Yang Yi, Zhao Hong, Zhang Yueqi, Fei Qinming, Shi Yi, Zhang Chi   +8 more
doaj   +1 more source

Superoxide dismutase downregulation in osteoarthritis progression and end-stage disease [PDF]

, 2010
Oxidative stress is proposed as an important factor in osteoarthritis (OA). To investigate the expression of the three superoxide dismutase (SOD) antioxidant enzymes in OA.
Boot-Handford, Raymond P., Clark, Ian M., Davidson, Rose K., Gabrielides, Christos, Kirkwood, Tom B. L., Scott, Jenny L., Swingler, Tracey E., Talyor, Robert W., Wallis, Gillian A., Young, David A.   +9 more
core   +1 more source

3D (Bio) Printing Combined Fiber Fabrication Methods for Tissue Engineering Applications: Possibilities and Limitations

Advanced Functional Materials, EarlyView.
Biofabrication aims at providing innovative technologies and tools for the fabrication of tissue‐like constructs for tissue engineering and regenerative medicine applications. By integrating multiple biofabrication technologies, such as 3D (bio) printing with fiber fabrication methods, it would be more realistic to reconstruct native tissue's ...
Waseem Kitana, Indra Apsite, Leonid Ionov   +2 more
wiley   +1 more source

Experimental Therapeutics for the Treatment of Osteoarthritis

Journal of Experimental Pharmacology, 2021
Gundula Schulze-Tanzil Department of Anatomy and Cell Biology, Paracelsus Medical University, Nuremberg, Bavaria, GermanyCorrespondence: Gundula Schulze-Tanzil Email gundula.schulze@pmu.ac.atAbstract: Osteoarthritis (OA) therapy remains a large challenge
Schulze-Tanzil G
doaj  

Regulation of MMP-3 expression and secretion by the chemokine eotaxin-1 in human chondrocytes

Journal of Biomedical Science, 2011
Background Osteoarthritis (OA) is characterized by the degradation of articular cartilage, marked by the breakdown of matrix proteins. Studies demonstrated the involvement of chemokines in this process, and some may potentially serve as diagnostic ...
Chao Pin-Zhir, Hsieh Ming-Shium, Cheng Chao-Wen, Lin Yung-Feng, Chen Chien-Ho   +4 more
doaj   +1 more source

Lack of Skeletal Effects in Mice with Targeted Disruptionof Prolyl Hydroxylase Domain 1 (Phd1) Gene Expressed in Chondrocytes

Life, 2022
The critical importance of hypoxia-inducible factor (HIF)s in the regulation of endochondral bone formation is now well established. HIF protein levels are closely regulated by the prolyl hydroxylase domain-containing protein (PHD) mediated ubiquitin ...
Weirong Xing, Destiney Larkin, Sheila Pourteymoor, William Tambunan, Gustavo A. Gomez, Elaine K. Liu, Subburaman Mohan   +6 more
doaj   +1 more source