Results 51 to 60 of about 70,223 (315)

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

Aging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey, Murilo Ramos Rocha, Cheyenne Palm, Vania Wang, Denys Balandin, Ethan Black, Kevin Y. Zhang, Fan Huang, Daniel J. Zabransky, Yash Chhabra, Mareike Peters, Gabriel Ghiaur, Ashani Weeraratna   +12 more
wiley   +1 more source

Experimental Therapeutics for the Treatment of Osteoarthritis

Journal of Experimental Pharmacology, 2021
Gundula Schulze-Tanzil Department of Anatomy and Cell Biology, Paracelsus Medical University, Nuremberg, Bavaria, GermanyCorrespondence: Gundula Schulze-Tanzil Email gundula.schulze@pmu.ac.atAbstract: Osteoarthritis (OA) therapy remains a large challenge
Schulze-Tanzil G
doaj  

Regulation of MMP-3 expression and secretion by the chemokine eotaxin-1 in human chondrocytes

Journal of Biomedical Science, 2011
Background Osteoarthritis (OA) is characterized by the degradation of articular cartilage, marked by the breakdown of matrix proteins. Studies demonstrated the involvement of chemokines in this process, and some may potentially serve as diagnostic ...
Chao Pin-Zhir, Hsieh Ming-Shium, Cheng Chao-Wen, Lin Yung-Feng, Chen Chien-Ho   +4 more
doaj   +1 more source

Lack of Skeletal Effects in Mice with Targeted Disruptionof Prolyl Hydroxylase Domain 1 (Phd1) Gene Expressed in Chondrocytes

Life, 2022
The critical importance of hypoxia-inducible factor (HIF)s in the regulation of endochondral bone formation is now well established. HIF protein levels are closely regulated by the prolyl hydroxylase domain-containing protein (PHD) mediated ubiquitin ...
Weirong Xing, Destiney Larkin, Sheila Pourteymoor, William Tambunan, Gustavo A. Gomez, Elaine K. Liu, Subburaman Mohan   +6 more
doaj   +1 more source

Associations of Sleep and Shift Work With Osteoarthritis Risk

Arthritis Care &Research, EarlyView.
Objective Daily rhythms may be critical for maintaining homeostasis of joint tissues. We aimed to investigate the relationships among circadian clock disruption, sleep, and osteoarthritis (OA) risk in humans. Methods In the UK Biobank, a prospective 500,000–person cohort, we evaluated associations among sleep duration, sleeplessness/insomnia, and shift
Elizabeth L. Yanik, Abigail Bridgeman, Erik D. Herzog, Vy Pham, Bradley A. Evanoff, Farshid Guilak   +5 more
wiley   +1 more source

Ameliorative Effects of Cardamonin on Monosodium Urate-Induced Gouty Arthritis through Inhibiting NLRP3 Inflammasome Mediation

Medicina, 2021
Background and Objectives: Gouty arthritis is an acute inflammatory response caused by the precipitation of monosodium urate (MSU) crystals in joints. The triggering of MSU leads to increased production of inflammatory cytokines, such as interleukin-1β ...
Chih-Chien Wang, Jeng-Wei Lu, Yi-Jen Peng, Chian-Her Lee, Herng-Sheng Lee, You-Hsiang Chu, Chun-Jung Huang, Yi-Jung Ho, Feng-Cheng Liu, Chia-Chun Wu   +9 more
doaj   +1 more source

The chondrocyte primary cilium [PDF]

Osteoarthritis and Cartilage, 2014
The presence and role of primary, or non-motile, cilia on chondrocytes has confused cartilage researchers for decades. Initial explanations attributed a vestigial nature to chondrocyte cilia. Evidence is now emerging that supports the role of the chondrocyte primary cilium as a sensory organelle, in particular, in mechanotransduction and as a ...
Ruhlen, R., Marberry, K.
openaire   +2 more sources

Packed for Ossification: High‐Density Bioprinting of hPDC Spheroids in HAMA Toward Endochondral Ossification

Advanced Healthcare Materials, EarlyView.
Human periosteum‐derived cell spheroids bioprinted at high density within a hyaluronic acid matrix promote fusion and hypertrophic cartilage formation in vitro. Early encapsulation enhances spheroid interaction and matrix maturation, generating scalable cartilage templates intended for endochondral bone regeneration.
Ane Albillos Sanchez, Maria Paula Marks, Paula Casademunt, Adrián Seijas‐Gamardo, Ioannis Papantoniou, Lorenzo Moroni, Carlos Mota   +6 more
wiley   +1 more source

Isorhamnetin inhibits mechanical stress-induced chondrocyte apoptosis through activation of the ROS/SRC/FOXO1 signaling pathway

Scientific Reports
Intervertebral disc degeneration (IDD), a chronic degenerative disease, is characterized by pain without a satisfactory therapeutic strategy. Excessive mechanical pressure contributes to the pathological development of IDD by inducing chondrocyte ...
Jinliang Lai, Guoqiang Yin, Fanmao Zhu, Jishang Huang, Xinghua Hu, Lei Liao, Rong Wu, Jiayu Tao, Shuyue Wang, Yang Xiao, Yiming Gu, Shan Li, Jie Zhou, Yadong Yang   +13 more
doaj   +1 more source

Direct Perfusion Improves Redifferentiation of Human Chondrocytes in Fibrin Hydrogel with the Deposition of Cartilage Pericellular Matrix

Applied Sciences, 2021
Articular cartilage has limited potential for self-repair, and cell-based strategies combining scaffolds and chondrocytes are currently used to treat cartilage injuries.
Alexandre Dufour, Frédéric Mallein-Gerin, Emeline Perrier-Groult   +2 more
doaj   +1 more source