Results 61 to 70 of about 76,519 (202)
Rice Science, 2020 The resveratrol-enriched transgenic rice line Iksan526 (IS526), first developed by the Rural Development Administration of Korea using genetic engineering techniques, shows beneficial health effects in mitigating metabolic syndrome and obesity.
Seong-Hui Eo, Song Ja Kim
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Exosomes in the Pathogenesis, Progression, and Treatment of Osteoarthritis
Bioengineering, 2022 Osteoarthritis (OA) is a prevalent and debilitating age-related joint disease characterized by articular cartilage degeneration, synovial membrane inflammation, osteophyte formation, as well as subchondral bone sclerosis.
Yishu Fan, Zhong Li, Yuchen He
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The role of mitochondrial quality control mechanisms in chondrocyte senescence
Experimental GerontologyChondrocytes are the exclusive cellular constituents of articular cartilage, and their functional status governs the health of the cartilage. The primary factor contributing to the deterioration of cartilage structure and function is chondrocyte ...
Tianlei Zhao +3 more
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Antioxidants, 2021 Osteoarthritis (OA) is a chronic degenerative joint disease characterized by the deterioration of articular cartilage. The progression of OA leads to an increase in inflammatory mediators in the joints, thereby promoting the destruction of the cartilage ...
Yi-Jen Peng +9 more
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Autologous Chondrocyte Implantation [PDF]
JBJS Essential Surgical Techniques, 2016 Autologous chondrocyte implantation (ACI) for the treatment of articular cartilage lesions of the knee joint provides successful and durable long-term outcomes.Obtain standing radiographs and magnetic resonance imaging (MRI) scans to identify all associated abnormalities (background factors).Evaluate the knee joint systematically and harvest cartilage ...
Tom, Minas, Takahiro, Ogura, Tim, Bryant
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Bone ResearchChondrocyte senescence is a critical pathological hallmark of osteoarthritis (OA). Aberrant mechanical stress is considered a pivotal determinant in chondrocyte aging; however, the precise underlying mechanism remains elusive.
Xiangyu Zu +8 more
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Chondrocyte De-Differentiation: Biophysical Cues to Nuclear Alterations
Cells, 2022 Autologous chondrocyte implantation (ACI) is a cell therapy to repair cartilage defects. In ACI a biopsy is taken from a non-load bearing area of the knee and expanded in-vitro.
Noor A. Al-Maslamani +6 more
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Latest Advances in Chondrocyte-Based Cartilage Repair
BiomedicinesChondrocyte-based cell therapy has been used for more than 30 years and is still considered to be a promising method of cartilage repair despite some limitations.
Li Yue, Ryan Lim, Brett D. Owens
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Analysis of strain-rate dependent mechanical behavior of single chondrocyte : a finite element study [PDF]
, 2014 Various studies have been conducted to investigate the effects of impact loading on cartilage damage and chondrocyte death. These have shown that the rate and magnitude of the applied strain significantly influence chondrocyte death, and that cell death ...
Nguyen, Trung Dung +3 more
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miR-149-5p mitigates tumor necrosis factor-α-induced chondrocyte apoptosis by inhibiting TRADD
, 2020 Introduction Chondrocyte apoptosis as a prominent characteristic is usually accompanied by cartilage degeneration in osteoarthritis (OA). Herein, we aimed to determine the roles of miR-149-5p in tumor necrosis factor-α (TNF-α)-induced chondrocyte ...
Shi-cheng Xie +4 more
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