Results 71 to 80 of about 76,519 (202)

Chondrocyte-based intraoperative processing strategies for the biological augmentation of a polyurethane meniscus replacement

, 2018
Purpose/aim of study: Menisectomies account for over 1.5 million surgical interventions in Europe annually, and there is a growing interest in regenerative strategies to improve outcomes in meniscal replacement. The overall objective of this study was to
Daniel J. Kelly (402881), Sara Romanazzo (1830007), Srujana Vedicherla (5489414), Conor T. Buckley (530337), Cathal J. Moran (5489417)   +4 more
core   +1 more source

Association of organs-crosstalk with the pathogenesis of osteoarthritis: cartilage as a key player

Frontiers in Endocrinology
Degeneration of articular cartilage is the hallmark pathologic change in osteoarthritis (OA). Cartilage not only serves as a shock-absorbing structure for movement but is also regulated by organs other than bone, while chondrocytes secrete cytokines that
Yingda Qin, Jingkai Di, Zijian Guo, Shuai Chen, Chuan Xiang   +4 more
doaj   +1 more source

The Immunosuppressant FTY720 (Fingolimod) enhances Glycosaminoglycan depletion in articular cartilage

BMC Musculoskeletal Disorders, 2011
Background FTY720 (Fingolimod) is a novel immunosuppressive drug investigated in clinical trials for organ transplantation and multiple sclerosis. It acts as a functional sphingosine-1-phosphate (S1P) receptor antagonist, thereby inhibiting the egress of
Stradner Martin H, Angerer Hannes, Ortner Thomas, Fuerst Florentine C, Setznagl Daniela, Kremser Marie-Luise, Hermann Josef, Graninger Winfried B   +7 more
doaj   +1 more source

Unveiling the potential of MSC extracellular vesicles: MiR-122-5p enhancing chondrocyte regeneration in osteoarthritis via autophagy mechanism

Stem Cell Research & Therapy
Background Osteoarthritis (OA) is one of the most prevalent degenerative joint diseases, while the mechanism by which extracellular vesicles (EVs) promote chondrocyte regeneration remains unclear. The study assessed the effect of hypoxic mesenchymal stem
Haifeng Zhang, Yanmeng Yang, Yingnan Wu, Vinitha Denslin, Yi Wei Justin Koh, Ling Liu, Wenhai Zhuo, Wing Moon Raymond Lam, Yinxian Yu, James Hoi Po Hui, Zheng Yang   +10 more
doaj   +1 more source

The miR‐6779/XIAP axis alleviates IL‐1β‐induced chondrocyte senescence and extracellular matrix loss in osteoarthritis

Animal Models and Experimental Medicine
Background Osteoarthritis (OA) is a long‐term degenerative joint disease worsening over time. Aging and chondrocyte senescence contribute to OA progression. MicroRNAs have been confirmed to regulate different cellular processes.
Zongchao Li, Aonan Dai, Xiaoxiang Fang, Kexing Tang, Kun Chen, Peng Gao, Jingyue Su, Xin Chen, Shengwu Yang, Zhenhan Deng, Liangjun Li   +10 more
doaj   +1 more source

Octacalcium phosphate crystals directly stimulate expression of inducible nitric oxide synthase through p38 and JNK mitogen-activated protein kinases in articular chondrocytes [PDF]

, 2005
Basic calcium phosphate (BCP) crystals, including hydroxyapatite, octacalcium phosphate (OCP) and carbonate-apatite, have been associated with severe osteoarthritis and several degenerative arthropathies.
Uzan, Benjamin, Lioté, Frédéric, Rey, Christian, Ea, Hang-Korng   +3 more
core   +1 more source

The role of DEL1 in chondrocyte expansion and mechanotransduction: an investigative study [PDF]

, 2009
Matrix-induced autologous chondrocyte implantation offers a potential cure for joint disease and is currently challenged by loss of differentiated phenotype upon culture.
Qusous, A.
core   +1 more source

Chondrocyte moves: clever strategies? [PDF]

, 2007
SummaryGoalsTo review the literature on chondrocyte movements and to develop plausible hypothesis for further work.DesignChondrocyte movements are herein defined as translocations of the cell body.
Morales, T.I.
core   +1 more source

Overexpression of miR-532-5p restrains oxidative stress response of chondrocytes in nontraumatic osteonecrosis of the femoral head by inhibiting ABL1

Open Medicine
This study is to probe into the meaning of serum miR-532-5p in nontraumatic osteonecrosis of the femoral head (ONFH), and a molecular mechanism of miR-532-5p in the development of nontraumatic ONFH.
Shang Peng, Liu Ying, Ren Jie, Liu Qingqing, Song Haobo, Jia Junqing, Liu Qiang   +6 more
doaj   +1 more source

Autologous chondrocyte implantation for cartilage repair: current perspectives

, 2015
Johannes Zellner,1 Werner Krutsch,1 Christian G Pfeifer,1 Matthias Koch,1 Michael Nerlich,1 Peter Angele1,2 1Department of Trauma Surgery, University Medical Center Regensburg, Regensburg, Germany; 2Sporthopaedicum, Regensburg, Germany Abstract: Over ...
Koch M, Nerlich M, Zellner J, Pfeifer CG, Krutsch W, Angele P   +5 more
core