Results 71 to 80 of about 70,223 (315)

ON THE SITE OF SULFATION IN THE CHONDROCYTE [PDF]

The Journal of Cell Biology, 1964
As observed autoradiographically in the cartilage of embryonic rats, radiosulfate is bound and concentrated only in vesicles of the juxtanuclear Golgi apparatus of secreting chondrocytes within 3 minutes of its presentation. From this area, vacuoles migrate peripherally and lodge in the subcortex; their sulfated contents are thence discharged via ...
G C, GODMAN, N, LANE
openaire   +2 more sources

Tracking Spatiotemporal Extracellular Matrix Evolution and Tissue Fusion in 3D Microtissues via Click Chemistry‐Based Metabolic Labelling

Advanced Healthcare Materials, EarlyView.
Metabolic labeling of nascent proteins in 3D microtissue spheroids provides a powerful analytical approach for large‐scale tissue engineering. Incorporation of non‐canonical amino acids with fluorescent tagging enables spatiotemporal investigation of extracellular matrix deposition and its evolution during multicellular tissue development and fusion ...
Theresa Koenig, F. Max Yavitt, Laura Veenendaal, Tim B. F. Woodfield   +3 more
wiley   +1 more source

Targeting Chondrocyte Hypertrophy as Strategies for the Treatment of Osteoarthritis

Bioengineering
Osteoarthritis (OA) is a common joint disease characterized by pain and functional impairment, which severely impacts the quality of life of middle-aged and elderly individuals.
Da-Long Dong, Guang-Zhen Jin
doaj   +1 more source

Chondrocyte De-Differentiation: Biophysical Cues to Nuclear Alterations

Cells, 2022
Autologous chondrocyte implantation (ACI) is a cell therapy to repair cartilage defects. In ACI a biopsy is taken from a non-load bearing area of the knee and expanded in-vitro.
Noor A. Al-Maslamani, Rachel Oldershaw, Simon Tew, Jude Curran, Pieter D’Hooghe, Kazuhiro Yamamoto, Henning F. Horn   +6 more
doaj   +1 more source

Gene Delivery to Chondrocytes

, 2023
AbstractDelivering genes to chondrocytes offers new possibilities both clinically, for treating conditions that affect cartilage, and in the laboratory, for studying the biology of chondrocytes. Advances in gene therapy have created a number of different viral and non-viral vectors for this purpose.
Christopher V, Nagelli, Christopher H, Evans, Rodolfo E, De la Vega   +2 more
openaire   +2 more sources

Standardized Effect Measures Informing Next‐Generation Strategies for Mechanical Stimulation in Cartilage Tissue Engineering

Advanced Healthcare Materials, EarlyView.
This systematic review quantitatively compares conventional mechanical stimulation strategies in cartilage tissue engineering across 85 heterogeneous in vitro studies. Applying standardized effect measures, meta‐analysis reveals that combined compression and shear loading optimally promotes cartilage matrix development.
Jiaqi K. Shen, Tony B. Huang, Catherine E. Davey, Elias Salzer, Gerjo J. V. M. Van Osch, Sandra J. Shefelbine, Marcus G. Pandy, Kathryn S. Stok   +7 more
wiley   +1 more source

SPI1 activates mitochondrial unfolded response signaling to inhibit chondrocyte senescence and relieves osteoarthritis

Bone Research
Chondrocyte senescence is a critical pathological hallmark of osteoarthritis (OA). Aberrant mechanical stress is considered a pivotal determinant in chondrocyte aging; however, the precise underlying mechanism remains elusive.
Xiangyu Zu, Shenghong Chen, Zhengyuan Li, Lin Hao, Wenhan Fu, Hui Zhang, Zongsheng Yin, Yin Wang, Jun Wang   +8 more
doaj   +1 more source

Influence of Mechanical Unloading on Articular Chondrocyte Dedifferentiation [PDF]

, 2018
Due to the limited self-repair capacity of articular cartilage, the surgical restoration of defective cartilage remains a major clinical challenge. The cell-based approach, which is known as autologous chondrocyte transplantation (ACT), has limited ...
Egli, Marcel, Martina Caliò, Fabienne Wyss, Marcel Egli, Gantenbein, Benjamin, Giger-Lange, Christina, Simon Wuest, Tanner, Samuel, Fabian Ille, Ille, Fabian, Wüest, Simon, Timon Wernas, Wernas, Timon, Benjamin Gantenbein, Caliò, Martina, Simon L. Wuest, Christina Giger-Lange, Wyss, Fabienne, Samuel Tanner   +18 more
core   +1 more source

Mechanics of chondrocyte hypertrophy [PDF]

Biomechanics and Modeling in Mechanobiology, 2011
Chondrocyte hypertrophy is a characteristic of osteoarthritis and dominates bone growth. Intra- and extracellular changes that are known to be induced by metabolically active hypertrophic chondrocytes are known to contribute to hypertrophy. However, it is unknown to which extent these mechanical conditions together can be held responsible for the total
Donkelaar, van, C.C., Wilson, W.
openaire   +3 more sources

Microgel‐Based 3D Bioprinting: A Convergent Strategy Integrating Material Design, Jamming Dynamics, and Biological Function

Advanced Healthcare Materials, EarlyView.
Microgel‐based 3D printed constructs represent a compelling and versatile innovation for engineering architecturally complex, dynamically remodelable, and biocompatible structures with high structural fidelity and bioactivity. By integrating material design, biofabrication, and biological function, these systems enable the development of adaptive ...
Elena Ghighină, Andreea Ioana Dinu, Jana Ghițman   +2 more
wiley   +1 more source