Results 1 to 10 of about 18,864 (197)

Methotrexate inhibits BMP4 and abrogates the hypertrophic chondrocyte phenotype of synovial fibroblasts in juvenile idiopathic arthritis

Pediatric Rheumatology Online Journal
Background Juvenile Idiopathic Arthritis (JIA) induces growth disturbances in affected joints. Fibroblast-like synoviocytes (FLS) play a crucial role in JIA pathogenesis.
Megan M. Simonds, Samuel T. Freer, Anne Marie C. Brescia   +2 more
doaj   +1 more source

IHH–GLI-1–HIF-2α signalling influences hypertrophic chondrocytes to exacerbate osteoarthritis progression

Journal of Orthopaedic Translation
Background: Chondrocyte hypertrophy is a potential target for osteoarthritis (OA) treatment, with Indian hedgehog (IHH), glioma-associated oncogene homolog (GLI), and hypoxia-inducible factor-2α (HIF-2α) being closely associated with chondrocyte ...
Chengming Zhang, Ruipeng Zhao, Zhengquan Dong, Yang Liu, Mengrou Liu, Haoqian Li, Yukun Yin, Xianda Che, Gaige Wu, li Guo, Pengcui Li, Xiaochun Wei, Ziquan Yang   +12 more
doaj   +1 more source

miR-892b Inhibits Hypertrophy by Targeting KLF10 in the Chondrogenesis of Mesenchymal Stem Cells

Molecular Therapy: Nucleic Acids, 2019
We investigated the functional role of miR-892b as a novel inhibitor of chondrocyte hypertrophy during TGF-β-mediated chondrogenesis of human mesenchymal stem cells (hMSCs). The expression of miR-892b during TGF-β-mediated chondrogenesis of hMSCs and the
Jong Min Lee, Ji-Yun Ko, Hye Young Kim, Jeong-Won Park, Farshid Guilak, Gun-Il Im   +5 more
doaj   +1 more source

Cell hypertrophy and type X collagen synthesis in cultured articular chondrocytes

Experimental Cell Research, 1991
Articular cartilage is a permanent tissue whose cells do not normally take part in the endochondral ossification process. To determine whether articular chondrocytes possess the potential to express traits associated with this process such as cell hypertrophy and type X collagen, chondrocytes were isolated from adult chicken tibial articular cartilage ...
M, Pacifici, E B, Golden, S L, Adams, I M, Shapiro   +3 more
openaire   +2 more sources

Role of miR-101a in targeting Cox-2 to attenuate chondrocyte hypertrophic differentiation and osteoarthritis progression

Genes and Diseases
MicroRNAs (miRNAs) are small non-coding RNAs that regulate gene expression post-transcriptionally, often playing critical roles in various biological processes.
Rui Mi, Jinnan Chen, Tianxiang Zhu, Huiqin Bian, Rong Wei, Rushuang Deng, Tiaotiao Han, Qian Wang, Yaojuan Lu, Longwei Qiao, Yuting Liang, Qiping Zheng   +11 more
doaj   +1 more source

Stiffened fibre-like microenvironment based on patterned equidistant micropillars directs chondrocyte hypertrophy. [PDF]

Mater Today Bio, 2023
Duan M, Xia S, Liu Y, Pu X, Chen Y, Zhou Y, Huang M, Pi C, Zhang D, Xie J.   +9 more
europepmc   +1 more source

Salmon calcitonin inhibited chondrocyte hypertrophy ex vivo [PDF]

Osteoarthritis and Cartilage, 2012
Chen-An, P., Hansen, N., He, Y., Andreassen, K.W., Henriksen, K., Karsdal, M.A., Bay-Jensen, A.-C.   +6 more
openaire   +1 more source

Chondrocyte Hypertrophy in Osteoarthritis: Mechanistic Studies and Models for the Identification of New Therapeutic Strategies. [PDF]

Cells, 2022
Chawla S, Mainardi A, Majumder N, Dönges L, Kumar B, Occhetta P, Martin I, Egloff C, Ghosh S, Bandyopadhyay A, Barbero A.   +10 more
europepmc   +1 more source

Effects of platelet rich plasma and chondrocyte co-culture on MSC chondrogenesis, hypertrophy and pathological responses [PDF]

, 2017
Regarding the inadequate healing capability of cartilage tissue, cell-based therapy is making the future of cartilage repair and regeneration. Mesenchymal stem cells (MSC) have shown great promise in cartilage regeneration.
Hanaee Ahvaz, Hana, Kabiri, Mahboubeh, Ramezanifard, Rouhallah   +2 more
core  

Inhibition of cyclooxygenase-2 impacts chondrocyte hypertrophy [PDF]

Osteoarthritis and Cartilage, 2012
Caron, M.J., Emans, P.J., Janssen, M.P., Sanen, K., Coolsen, M.M., Voss, L., Surtel, D.A., Cremers, A., Voncken, J.-W., Welting, T.J., van Rhijn, L.W.   +10 more
openaire   +1 more source