Targeting Chondrocyte Hypertrophy as Strategies for the Treatment of Osteoarthritis [PDF]
BioengineeringOsteoarthritis (OA) is a common joint disease characterized by pain and functional impairment, which severely impacts the quality of life of middle-aged and elderly individuals.
Da-Long Dong, Guang-Zhen Jin
exaly +7 more sources
Functional Duality of Chondrocyte Hypertrophy and Biomedical Application Trends in Osteoarthritis [PDF]
Pharmaceutics, 2021 Chondrocyte hypertrophy is one of the key indicators in the progression of osteoarthritis (OA). However, compared with other OA indications, such as cartilage collapse, sclerosis, inflammation, and protease activation, the mechanisms by which chondrocyte
Yoshie Arai, Jinsung Ahn, Hansoo Park
exaly +8 more sources
Suppressing Chondrocyte Hypertrophy to Build Better Cartilage [PDF]
Bioengineering, 2023 Current clinical strategies for restoring cartilage defects do not adequately consider taking the necessary steps to prevent the formation of hypertrophic tissue at injury sites.
Christian Shigley +4 more
doaj +5 more sources
DLX5 promotes Col10a1 expression and chondrocyte hypertrophy and is involved in osteoarthritis progression [PDF]
Genes and Diseases, 2023 Osteoarthritis (OA) has been considered non-reversible as articular cartilage wears down with limited repair capacity. Enhanced chondrocyte hypertrophy and increased type X collagen gene (COL10A1) expression have been associated with OA.
Huiqin Bian, Yaojuan Lu, Longwei Qiao
exaly +5 more sources
The Role of Chondrocyte Hypertrophy and Senescence in Osteoarthritis Initiation and Progression [PDF]
International Journal of Molecular Sciences, 2020 Osteoarthritis (OA) is the most common joint disease that causes pain and disability in the adult population. OA is primarily caused by trauma induced by an external force or by age-related cartilage damage.
Yeri Alice Rim, Yoojun Nam, Ji Hyeon Ju
exaly +6 more sources
The synovial microenvironment suppresses chondrocyte hypertrophy and promotes articular chondrocyte differentiation [PDF]
npj Regenerative Medicine, 2022 During the development of the appendicular skeleton, the cartilaginous templates undergo hypertrophic differentiation and remodels into bone, except for the cartilage most adjacent to joint cavities where hypertrophic differentiation and endochondral ...
Michael Chau +9 more
doaj +4 more sources
The regulatory significance of chondrocyte hypertrophy in maintaining chondrocyte homeostasis, regeneration and repair [PDF]
Future Science OAChondrocyte hypertrophy is a pivotal biological process in skeletal development and disease progression, with its precise regulation being essential for maintaining cartilage homeostasis and promoting tissue repair.
Jingxin Li +8 more
doaj +3 more sources
Mechanical compression induces chondrocyte hypertrophy by regulating Runx2 O-GlcNAcylation during temporomandibular joint condyle degeneration [PDF]
Bone and Joint ResearchAims: Excessive chondrocyte hypertrophy is a common feature in cartilage degeneration which is susceptible to joint overloading, but the relationship between mechanical overloading and chondrocyte hypertrophy still remains elusive.
Yan Xiao +8 more
exaly +4 more sources
IRE1α regulates the PTHrP-IHH feedback loop to orchestrate chondrocyte hypertrophy and cartilage mineralization [PDF]
Genes and DiseasesCartilage development is controlled by the highly synergistic proliferation and differentiation of growth plate chondrocytes, in which the Indian hedgehog (IHH) and parathyroid hormone-related protein-parathyroid hormone-1 receptor (PTHrP-PTH1R) feedback
Mengtian Fan +14 more
doaj +3 more sources
Ubiquitin-specific protease 26 facilitates endochondral ossification by driving chondrocyte hypertrophy and mineralization [PDF]
Bone ResearchChondrocyte hypertrophy and mineralization are essential for endochondral ossification; however, the mechanisms underlying these processes remain incompletely understood.
Changwei Li +8 more
doaj +2 more sources