Results 21 to 30 of about 18,864 (197)

Histone Deacetylase 4 Controls Chondrocyte Hypertrophy during Skeletogenesis [PDF]

Cell, 2004
Histone deacetylases (HDACs) modulate cell growth and differentiation by governing chromatin structure and repressing the activity of specific transcription factors. We showed previously that HDAC9 acts as a negative regulator of cardiomyocyte hypertrophy and skeletal muscle differentiation.
Vega, Rick B., Matsuda, Koichi, Oh, Junyoung, Barbosa, Ana C., Yang, Xiangli, Meadows, Eric, McAnally, John, Pomajzl, Chris, Shelton, John M., Richardson, James A., Karsenty, Gerard, Olson, Eric N.   +11 more
openaire   +4 more sources

Neural cell adhesion molecule regulates chondrocyte hypertrophy in chondrogenic differentiation and experimental osteoarthritis [PDF]

Stem Cells Translational Medicine, 2020
Chondrocyte hypertrophy‐like change is an important pathological process of osteoarthritis (OA), but the mechanism remains largely unknown. Neural cell adhesion molecule (NCAM) is highly expressed and involved in the chondrocyte differentiation of ...
Bin‐Feng Cheng, Jun‐Jiang Lian, Hai‐Jie Yang, Lei Wang, Hao‐Heng Yu, Jia‐Jia Bi, Yao‐Xin Gao, Su‐Juan Chen, Mian Wang, Zhi‐Wei Feng   +9 more
doaj   +2 more sources

Pterosin B prevents chondrocyte hypertrophy and osteoarthritis in mice by inhibiting Sik3 [PDF]

Nature Communications, 2016
Therapies are needed for the prevention of chondrocyte hypertrophy and thinning of articular cartilage, features of osteoarthritic joint destruction. Here, the authors show that interfering with Sik3 signalling can increase the size of the chondrocyte ...
Yasuhito Yahara, Hiroshi Takemori, Minoru Okada, Azuma Kosai, Akihiro Yamashita, Tomohito Kobayashi, Kaori Fujita, Yumi Itoh, Masahiro Nakamura, Hiroyuki Fuchino, Nobuo Kawahara, Naoshi Fukui, Akira Watanabe, Tomoatsu Kimura, Noriyuki Tsumaki   +14 more
doaj   +2 more sources

The Level of Histone Deacetylase 4 is Associated with Aging Cartilage Degeneration and Chondrocyte Hypertrophy [PDF]

Journal of Inflammation Research, 2022
Zhengquan Dong,1 Zhou Ma,1 Meiju Yang,2 Linlin Cong,2 Ruipeng Zhao,1 Liyun Cheng,3 Jian Sun,1 Yunfei Wang,1 Ruijia Yang,2 Xiaochun Wei,1 Pengcui Li1 1Department of Orthopaedic, Shanxi Key Laboratory of Bone and Soft Tissue Injury Repair, The Second ...
Dong Z, Ma Z, Yang M, Cong L, Zhao R, Cheng L, Sun J, Wang Y, Yang R, Wei X, Li P   +10 more
doaj   +2 more sources

IRE1α regulates the PTHrP-IHH feedback loop to orchestrate chondrocyte hypertrophy and cartilage mineralization [PDF]

Genes and Diseases
Cartilage development is controlled by the highly synergistic proliferation and differentiation of growth plate chondrocytes, in which the Indian hedgehog (IHH) and parathyroid hormone-related protein-parathyroid hormone-1 receptor (PTHrP-PTH1R) feedback
Mengtian Fan, Nana Geng, Xingyue Li, Danyang Yin, Yuyou Yang, Rong Jiang, Cheng Chen, Naibo Feng, Li Liang, Xiaoli Li, Fengtao Luo, Huabing Qi, Qiaoyan Tan, Yangli Xie, Fengjin Guo   +14 more
doaj   +2 more sources

The Incidence and Clinical Relevance of Graft Hypertrophy After Matrix-Based Autologous Chondrocyte Implantation [PDF]

American Journal of Sports Medicine, 2012
Background: Graft hypertrophy is the most common complication of periosteal autologous chondrocyte implantation (p-ACI). Purpose: The aim of this prospective study was to analyze the development, the incidence rate, and the persistence of graft ...
Annie Horng, Eckstein F, Isa Feist-Pagenstert, Matthias F. Pietschmann, Mehmet F. Gülecyüz, Peter E. Müller, Thomas R. Niethammer, Volkmar Jansson   +7 more
core   +3 more sources

Smad4 regulates growth plate matrix production and chondrocyte polarity [PDF]

Biology Open, 2017
Smad4 is an intracellular effector of the TGFβ family that has been implicated in Myhre syndrome, a skeletal dysplasia characterized by short stature, brachydactyly and stiff joints.
Amanda T. Whitaker, Ellora Berthet, Andrea Cantu, Diana J. Laird, Tamara Alliston   +4 more
doaj   +5 more sources

Reactive oxygen species induce chondrocyte hypertrophy in endochondral ossification [PDF]

The Journal of Experimental Medicine, 2007
Chondrocyte hypertrophy during endochondral ossification is a well-controlled process in which proliferating chondrocytes stop proliferating and differentiate into hypertrophic chondrocytes, which then undergo apoptosis. Chondrocyte hypertrophy induces angiogenesis and mineralization.
Morita, Kozo, Miyamoto, Takeshi, Fujita, Nobuyuki, Kubota, Yoshiaki, Ito, Keisuke, Takubo, Keiyo, Miyamoto, Kana, Ninomiya, Ken, Suzuki, Toru, Iwasaki, Ryotaro, Yagi, Mitsuru, Takaishi, Hironari, Toyama, Yoshiaki, Suda, Toshio   +13 more
openaire   +4 more sources

MEF2C Transcription Factor Controls Chondrocyte Hypertrophy and Bone Development [PDF]

Developmental Cell, 2007
Chondrocyte hypertrophy is essential for endochondral bone development. Unexpectedly, we discovered that MEF2C, a transcription factor that regulates muscle and cardiovascular development, controls bone development by activating the gene program for chondrocyte hypertrophy.
Arnold, Michael A., Kim, Yuri, Czubryt, Michael P., Phan, Dillon, McAnally, John, Qi, Xiaoxia, Shelton, John M., Richardson, James A., Bassel-Duby, Rhonda, Olson, Eric N.   +9 more
openaire   +4 more sources

Notch signaling controls chondrocyte hypertrophy via indirect regulation of Sox9 [PDF]

Bone Research, 2015
RBPjk-dependent Notch signaling regulates both the onset of chondrocyte hypertrophy and the progression to terminal chondrocyte maturation during endochondral ossification.
Hilton, Matthew J, Kohn, Anat, Liu, Zhaoyang, Mirando, Anthony J, O\u27Keefe, Regis J, Rutkowski, Timothy P, Zuscik, Michael J   +6 more
core   +7 more sources