Results 21 to 30 of about 12,394 (186)

Chondrocyte hypertrophy and osteoarthritis: role in initiation and progression of cartilage degeneration?

Osteoarthritis and Cartilage, 2012
Item does not contain fulltextOBJECTIVE: To review the literature on the role and regulation of chondrocyte terminal differentiation (hypertrophy-like changes) in osteoarthritis (OA) and to integrate this in a conceptual model of primary OA development ...
P M Van Der Kraan, W B Van Den Berg
exaly   +2 more sources

Pterosin B prevents chondrocyte hypertrophy and osteoarthritis in mice by inhibiting Sik3 [PDF]

Nature Communications, 2016
Therapies are needed for the prevention of chondrocyte hypertrophy and thinning of articular cartilage, features of osteoarthritic joint destruction. Here, the authors show that interfering with Sik3 signalling can increase the size of the chondrocyte ...
Yasuhito Yahara, Hiroshi Takemori, Minoru Okada, Azuma Kosai, Akihiro Yamashita, Tomohito Kobayashi, Kaori Fujita, Yumi Itoh, Masahiro Nakamura, Hiroyuki Fuchino, Nobuo Kawahara, Naoshi Fukui, Akira Watanabe, Tomoatsu Kimura, Noriyuki Tsumaki   +14 more
doaj   +2 more sources

Neuronal guidance factor Sema3A inhibits neurite ingrowth and prevents chondrocyte hypertrophy in the degeneration of knee cartilage in mice, monkeys and humans [PDF]

Bone Research
Osteoarthritis (OA) is a degenerative joint disease accompanied with the loss of cartilage and consequent nociceptive symptoms. Normal articular cartilage maintains at aneural state.
Shishu Huang, Dashuang Gao, Zhenxia Li, Hongchen He, Xi Yu, Xuanhe You, Diwei Wu, Ze Du, Jiancheng Zeng, Xiaojun Shi, Qinshen Hu, Yong Nie, Zhong Zhang, Zeyu Luo, Duan Wang, Zhihe Zhao, Lingli Li, Guanglin Wang, Liping Wang, Zongke Zhou, Di Chen, Fan Yang   +21 more
doaj   +2 more sources

M2 macrophage-derived exosomal miR-26b-5p regulates macrophage polarization and chondrocyte hypertrophy by targeting TLR3 and COL10A1 to alleviate osteoarthritis [PDF]

Journal of Nanobiotechnology
Osteoarthritis (OA) is one of the most prevalent chronic musculoskeletal diseases among the elderly population. In this study, macrophage-derived exosomes were isolated and identified.
Yufan Qian, Genglei Chu, Lei Zhang, Zhikai Wu, Qiuyuan Wang, Jiong Jiong Guo, Feng Zhou   +6 more
doaj   +2 more sources

Identification of TGFβ-related genes regulated in murine osteoarthritis and chondrocyte hypertrophy by comparison of multiple microarray datasets [PDF]

Bone, 2018
Objective: Osteoarthritis (OA) is a joint disease characterized by progressive degeneration of articular cartilage. Some features of OA, including chondrocyte hypertrophy and focal calcification of articular cartilage, resemble the endochondral ...
Laurie M G De Kroon, Bent Brachvogel, Roberto Narcisi   +2 more
exaly   +4 more sources

Activation of Indian hedgehog promotes chondrocyte hypertrophy and upregulation of MMP-13 in human osteoarthritic cartilage

Osteoarthritis and Cartilage, 2012
SummaryObjectiveThe objectives of this study were to (1) determine the correlation between osteoarthritis (OA) and Indian hedgehog (Ihh) expression, and (2) establish the effects of Ihh on expression of markers of chondrocyte hypertrophy and matrix ...
Braden C Fleming, Richard M Terek, Ming Pei   +2 more
exaly   +2 more sources

Expression of RMRP RNA is regulated in chondrocyte hypertrophy and determines chondrogenic differentiation [PDF]

Scientific Reports, 2017
Mutations in the RMRP-gene, encoding the lncRNA component of the RNase MRP complex, are the origin of cartilage-hair hypoplasia. Cartilage-hair hypoplasia is associated with severe dwarfism caused by impaired skeletal development.
Mandy M. F. Steinbusch, Marjolein M. J. Caron, Don A. M. Surtel, Franziska Friedrich, Ekkehart Lausch, Ger J. M. Pruijn, Wouter Verhesen, Blanche L. M. Schroen, Lodewijk W. van Rhijn, Bernhard Zabel, Tim J. M. Welting   +10 more
doaj   +2 more sources

A Qualitative Model of the Differentiation Network in Chondrocyte Maturation: A Holistic View of Chondrocyte Hypertrophy. [PDF]

PLOS ONE, 2016
peer reviewedDifferentiation of chondrocytes towards hypertrophy is a natural process whose control is essential in endochondral bone formation. It is additionally thought to play a role in several pathophysiological processes, with osteoarthritis being ...
Johanna Bolander (3140484), Leijten, Jeroen, Bolander, Johanna, Leijten, Jeroen; id_orcid, Luyten, Frank P., Jeroen Leijten, Johan Kerkhofs (167468), Frank P. Luyten (143446), Liesbet Geris (127738), Luyten, Frank, Post, Janine N., Post, Janine N.; id_orcid, Janine N. Post (123413), Liesbet Geris, Jeroen Leijten (2835695), Johan Kerkhofs, Kerkhofs, Johan, Janine N Post, Frank P Luyten, Geris, Liesbet, Johanna Bolander   +20 more
core   +5 more sources

Transglutaminase 2 is a marker of chondrocyte hypertrophy and osteoarthritis severity in the Hartley guinea pig model of knee OA

Osteoarthritis and Cartilage, 2009
SummaryObjectiveThe transglutaminase (TG) isoenzyme TG2, which catalyzes protein cross-linking via transamidation, influences healing phenotype in multiple forms of tissue injury.
J L Huebner, V B Kraus, Robert A Terkeltaub   +2 more
exaly   +2 more sources

MMP-13 is induced during chondrocyte hypertrophy

Journal of Cellular Biochemistry, 2000
During development, mRNA for matrix metalloproteinase-13 (MMP-13) is found associated with cartilage undergoing hypertrophy, suggesting that this collagenase plays a role in cell enlargement and/or cartilage calcification.
Nooreyazdan, M., Leboy, Phoebe S., Pacifici, Maurizio, D\u27Angelo, Marina, Yan, Z., Billings, Paul C., Sarment, D. S.   +6 more
core   +3 more sources