Results 21 to 30 of about 11,550 (158)
Osteoarthritis as an evolutionary legacy: Biological ageing and chondrocyte hypertrophy. [PDF]
Osteoarthr Cartil OpenOsteoarthritis (OA) is a progressive joint disease habitually linked to ageing, characterized by the gradual breakdown of cartilage leading to pain and reduced mobility. Historically viewed as mainly a "wear and tear" condition, new insights suggest that OA may be part of an evolutionary, age-related biological process rather than mainly driven by ...
van der Kraan PM.
europepmc +5 more sources
In Vitro Study of Licorice on IL-1β-Induced Chondrocytes and In Silico Approach for Osteoarthritis
Pharmaceuticals, 2021 Osteoarthritis (OA) is a common degenerative joint disorder that affects joint function, mobility, and pain. The release of proinflammatory cytokines stimulates matrix metalloproteinases (MMPs) and aggrecanase production which further induces articular ...
Akhtar Ali +12 more
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Mechanics of chondrocyte hypertrophy [PDF]
Biomechanics and Modeling in Mechanobiology, 2011 Chondrocyte hypertrophy is a characteristic of osteoarthritis and dominates bone growth. Intra- and extracellular changes that are known to be induced by metabolically active hypertrophic chondrocytes are known to contribute to hypertrophy. However, it is unknown to which extent these mechanical conditions together can be held responsible for the total
Donkelaar, van, C.C., Wilson, W.
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Regulating the Regulators of Chondrocyte Hypertrophy [PDF]
Journal of Bone and Mineral Research, 1999 THE DEVELOPMENT, growth, and maintenance of a functional skeleton relies on the existence of several different types of chondrocytes with markedly different fates. The articular chondrocytes on the surface of joints are expected to persist throughout life, producing extracellular matrix components which provide a cushion to distribute load on bone at ...
S W, Volk, P S, Leboy
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The Wnt/beta-catenin pathway interacts differentially with PTHrP signaling to control chondrocyte hypertrophy and final maturation. [PDF]
PLoS ONE, 2009 Sequential proliferation, hypertrophy and maturation of chondrocytes are required for proper endochondral bone development and tightly regulated by cell signaling.
Xizhi Guo +3 more
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WISP3 - IGF1 interaction regulates chondrocyte hypertrophy [PDF]
Journal of Cell Science, 2013 WISP3 (Wnt Induced Secreted Protein 3) is a multi-domain protein of mesenchymal origin. Mutations in several domains of WISP3 cause PPRD (Progressive Pseudo Rheumatoid Dysplasia), which is associated with cartilage loss and restricted skeletal development.
Srinivasa Rao, Repudi +2 more
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Thyroxine downregulates Sox9 and promotes chondrocyte hypertrophy [PDF]
Biochemical and Biophysical Research Communications, 2003 Thyroid hormones exert a profound effect on development, growth, and metabolism of skeleton. In the present study, we evaluated the effects of thyroxine (T4) and growth hormone (GH) on the terminal differentiation of rib growth plate chondrocytes in three-dimensional pellet culture.
Yasunori, Okubo, A Hari, Reddi
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Effects of Concanavalin A on Chondrocyte Hypertrophy and Matrix Calcification [PDF]
Journal of Biological Chemistry, 1997 Resting chondrocytes do not usually undergo differentiation to the hypertrophic stage and calcification. However, incubating these cells with concanavalin A resulted in 10-100-fold increases in alkaline phosphatase activity, binding of 1,25(OH)2-vitamin D3, type X collagen synthesis, 45Ca incorporation into insoluble material, and calcium content.
W, Yan +8 more
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Regulation of α5 and αV Integrin Expression by GDF-5 and BMP-7 in Chondrocyte Differentiation and Osteoarthritis. [PDF]
PLoS ONE, 2015 The Integrin β1 family is the major receptors of the Extracellular matrix (ECM), and the synthesis and degradation balance of ECM is seriously disrupted during Osteoarthritis (OA).
David Garciadiego-Cázares +5 more
doaj +1 more source
Arthritis Research & Therapy, 2020 Background Osteoarthritis (OA), the most common joint disorder, is characterized by a progressive degradation of articular cartilage. Increasing evidence suggests that OA is closely associated with cartilage pathologies including chondrocyte hypertrophy ...
Na Liu +11 more
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