Results 21 to 30 of about 109,571 (195)

IRE1α regulates the PTHrP-IHH feedback loop to orchestrate chondrocyte hypertrophy and cartilage mineralization [PDF]

Genes and Diseases
Cartilage development is controlled by the highly synergistic proliferation and differentiation of growth plate chondrocytes, in which the Indian hedgehog (IHH) and parathyroid hormone-related protein-parathyroid hormone-1 receptor (PTHrP-PTH1R) feedback
Mengtian Fan, Nana Geng, Xingyue Li, Danyang Yin, Yuyou Yang, Rong Jiang, Cheng Chen, Naibo Feng, Li Liang, Xiaoli Li, Fengtao Luo, Huabing Qi, Qiaoyan Tan, Yangli Xie, Fengjin Guo   +14 more
doaj   +3 more sources

The vacuolar H+ ATPase V0 subunit d2 is associated with chondrocyte hypertrophy and supports chondrocyte differentiation [PDF]

Bone Reports, 2017
Chondrocyte hypertrophy makes important contributions to bone development and growth. We have investigated a number of novel cartilage genes identified in a recent transcriptomic study to determine whether they are differentially expressed between ...
Babatunde A. Ayodele, Michiko Mirams, Charles N. Pagel, Eleanor J. Mackie   +3 more
doaj   +6 more sources

Mechanics of chondrocyte hypertrophy [PDF]

Biomechanics and Modeling in Mechanobiology, 2011
Chondrocyte hypertrophy is a characteristic of osteoarthritis and dominates bone growth. Intra- and extracellular changes that are known to be induced by metabolically active hypertrophic chondrocytes are known to contribute to hypertrophy. However, it is unknown to which extent these mechanical conditions together can be held responsible for the total
Donkelaar, van, C.C., Wilson, W.
openaire   +5 more sources

Ubiquitin-specific protease 26 facilitates endochondral ossification by driving chondrocyte hypertrophy and mineralization [PDF]

Bone Research
Chondrocyte hypertrophy and mineralization are essential for endochondral ossification; however, the mechanisms underlying these processes remain incompletely understood.
Changwei Li, Yiming Xu, Li Zhou, Leilei Chang, Zhou Dan, Yunhe Jiang, Chao Wang, Lianfu Deng, Guoqing Tang   +8 more
doaj   +2 more sources

The Wnt/beta-catenin pathway interacts differentially with PTHrP signaling to control chondrocyte hypertrophy and final maturation. [PDF]

PLoS ONE, 2009
Sequential proliferation, hypertrophy and maturation of chondrocytes are required for proper endochondral bone development and tightly regulated by cell signaling.
Xizhi Guo, Kinglun Kingston Mak, Makoto M Taketo, Yingzi Yang   +3 more
doaj   +2 more sources

SPRY4 acts as an indicator of osteoarthritis severity and regulates chondrocyte hypertrophy and ECM protease expression [PDF]

npj Regenerative Medicine, 2021
Osteoarthritis (OA) causes serious changes in the metabolic and signaling pathways of chondrocytes, including the mitogen-activated protein kinase (MAPK) pathway.
Sunghyun Park, Yoshie Arai, Alvin Bello, Hansoo Park, Dohyun Kim, Kyung-Soon Park, Soo-Hong Lee   +6 more
doaj   +2 more sources

Mechanical compression induces chondrocyte hypertrophy by regulating Runx2 O-GlcNAcylation during temporomandibular joint condyle degeneration [PDF]

Bone & Joint Research
Aims: Excessive chondrocyte hypertrophy is a common feature in cartilage degeneration which is susceptible to joint overloading, but the relationship between mechanical overloading and chondrocyte hypertrophy still remains elusive.
Yan Xiao, Zhang Yue, He Zijing, Zheng Yao, Mao Sui, Zeng Xuemin, Zhang Qiang, Yuan Xiao, Ren Dapeng   +8 more
doaj   +2 more sources

The Level of Histone Deacetylase 4 is Associated with Aging Cartilage Degeneration and Chondrocyte Hypertrophy [PDF]

Journal of Inflammation Research, 2022
Zhengquan Dong,1 Zhou Ma,1 Meiju Yang,2 Linlin Cong,2 Ruipeng Zhao,1 Liyun Cheng,3 Jian Sun,1 Yunfei Wang,1 Ruijia Yang,2 Xiaochun Wei,1 Pengcui Li1 1Department of Orthopaedic, Shanxi Key Laboratory of Bone and Soft Tissue Injury Repair, The Second ...
Dong Z, Ma Z, Yang M, Cong L, Zhao R, Cheng L, Sun J, Wang Y, Yang R, Wei X, Li P   +10 more
doaj   +2 more sources

M2 macrophage-derived exosomal miR-26b-5p regulates macrophage polarization and chondrocyte hypertrophy by targeting TLR3 and COL10A1 to alleviate osteoarthritis [PDF]

Journal of Nanobiotechnology
Osteoarthritis (OA) is one of the most prevalent chronic musculoskeletal diseases among the elderly population. In this study, macrophage-derived exosomes were isolated and identified.
Yufan Qian, Genglei Chu, Lei Zhang, Zhikai Wu, Qiuyuan Wang, Jiong Jiong Guo, Feng Zhou   +6 more
doaj   +2 more sources

Neuronal guidance factor Sema3A inhibits neurite ingrowth and prevents chondrocyte hypertrophy in the degeneration of knee cartilage in mice, monkeys and humans [PDF]

Bone Research
Osteoarthritis (OA) is a degenerative joint disease accompanied with the loss of cartilage and consequent nociceptive symptoms. Normal articular cartilage maintains at aneural state.
Shishu Huang, Dashuang Gao, Zhenxia Li, Hongchen He, Xi Yu, Xuanhe You, Diwei Wu, Ze Du, Jiancheng Zeng, Xiaojun Shi, Qinshen Hu, Yong Nie, Zhong Zhang, Zeyu Luo, Duan Wang, Zhihe Zhao, Lingli Li, Guanglin Wang, Liping Wang, Zongke Zhou, Di Chen, Fan Yang   +21 more
doaj   +2 more sources