Results 31 to 40 of about 109,571 (195)

MEF2C Transcription Factor Controls Chondrocyte Hypertrophy and Bone Development [PDF]

Developmental Cell, 2007
Chondrocyte hypertrophy is essential for endochondral bone development. Unexpectedly, we discovered that MEF2C, a transcription factor that regulates muscle and cardiovascular development, controls bone development by activating the gene program for chondrocyte hypertrophy.
Arnold, Michael A., Kim, Yuri, Czubryt, Michael P., Phan, Dillon, McAnally, John, Qi, Xiaoxia, Shelton, John M., Richardson, James A., Bassel-Duby, Rhonda, Olson, Eric N.   +9 more
openaire   +4 more sources

MMP-13 is induced during chondrocyte hypertrophy

Journal of Cellular Biochemistry, 2000
During development, mRNA for matrix metalloproteinase-13 (MMP-13) is found associated with cartilage undergoing hypertrophy, suggesting that this collagenase plays a role in cell enlargement and/or cartilage calcification. Using chondrocytes from prehypertrophic cartilage of chick embryo sternae, we have examined the relationship between MMP-13 ...
D'Angelo, Marina, Yan, Z., Nooreyazdan, M., Pacifici, Maurizio, Sarment, D. S., Billings, Paul C., Leboy, Phoebe S.   +6 more
core   +4 more sources

Pharmacological treatments for osteoarthritis: Emerging therapeutic strategies targeting chondrocyte hypertrophy and inflammation [PDF]

, 2022
In this thesis I aimed to identify pharmacological targets for osteoarthritis, targeting chondrocyte hypertrophy and ...
Ferrao Blanco, Mauricio
core   +12 more sources

The role of histone deacetylase 4 during chondrocyte hypertrophy and endochondral bone development [PDF]

Bone and Joint Research, 2020
Xiaochun Wei, Lei Wei
exaly   +2 more sources

In Vitro Study of Licorice on IL-1β-Induced Chondrocytes and In Silico Approach for Osteoarthritis

Pharmaceuticals, 2021
Osteoarthritis (OA) is a common degenerative joint disorder that affects joint function, mobility, and pain. The release of proinflammatory cytokines stimulates matrix metalloproteinases (MMPs) and aggrecanase production which further induces articular ...
Akhtar Ali, YoungJoon Park, Jeonghoon Lee, Hyo-Jin An, Jong-Sik Jin, Jong-Hyun Lee, Jaeki Chang, Dong-Keun Kim, Bonhyuk Goo, Yeon Cheol Park, Kang-Hyun Leem, Shin Seong, Wonnam Kim   +12 more
doaj   +1 more source

Regulating the Regulators of Chondrocyte Hypertrophy [PDF]

Journal of Bone and Mineral Research, 1999
THE DEVELOPMENT, growth, and maintenance of a functional skeleton relies on the existence of several different types of chondrocytes with markedly different fates. The articular chondrocytes on the surface of joints are expected to persist throughout life, producing extracellular matrix components which provide a cushion to distribute load on bone at ...
S W, Volk, P S, Leboy
openaire   +2 more sources

Osteoarthritis as an evolutionary legacy: Biological ageing and chondrocyte hypertrophy. [PDF]

Osteoarthr Cartil Open
Osteoarthritis (OA) is a progressive joint disease habitually linked to ageing, characterized by the gradual breakdown of cartilage leading to pain and reduced mobility. Historically viewed as mainly a "wear and tear" condition, new insights suggest that OA may be part of an evolutionary, age-related biological process rather than mainly driven by ...
van der Kraan PM.
europepmc   +5 more sources

WISP3 - IGF1 interaction regulates chondrocyte hypertrophy [PDF]

Journal of Cell Science, 2013
WISP3 (Wnt Induced Secreted Protein 3) is a multi-domain protein of mesenchymal origin. Mutations in several domains of WISP3 cause PPRD (Progressive Pseudo Rheumatoid Dysplasia), which is associated with cartilage loss and restricted skeletal development.
Srinivasa Rao, Repudi, Milan, Patra, Malini, Sen   +2 more
openaire   +2 more sources

Effects of Concanavalin A on Chondrocyte Hypertrophy and Matrix Calcification [PDF]

Journal of Biological Chemistry, 1997
Resting chondrocytes do not usually undergo differentiation to the hypertrophic stage and calcification. However, incubating these cells with concanavalin A resulted in 10-100-fold increases in alkaline phosphatase activity, binding of 1,25(OH)2-vitamin D3, type X collagen synthesis, 45Ca incorporation into insoluble material, and calcium content.
W, Yan, H, Pan, H, Ishida, K, Nakashima, F, Suzuki, M, Nishimura, A, Jikko, R, Oda, Y, Kato   +8 more
openaire   +2 more sources

Thyroxine downregulates Sox9 and promotes chondrocyte hypertrophy [PDF]

Biochemical and Biophysical Research Communications, 2003
Thyroid hormones exert a profound effect on development, growth, and metabolism of skeleton. In the present study, we evaluated the effects of thyroxine (T4) and growth hormone (GH) on the terminal differentiation of rib growth plate chondrocytes in three-dimensional pellet culture.
Yasunori, Okubo, A Hari, Reddi
openaire   +2 more sources