A controlled release bupivacaine-alginate construct: Effect on chondrocyte hypertrophy conversion [PDF]
Osteoarthritis and Cartilage Open, 2020 Objective: Osteoarthritis is a degenerative disease of the joint, affecting over 30 million people in the US1. A key characteristic of OA is chondrocyte hypertrophy, characterized by chondrocyte changes to a more rounded and osteoblastic phenotype ...
Mollie S. Davis +8 more
doaj +2 more sources
M2 macrophage-derived exosomal miR-26b-5p regulates macrophage polarization and chondrocyte hypertrophy by targeting TLR3 and COL10A1 to alleviate osteoarthritis [PDF]
Journal of NanobiotechnologyOsteoarthritis (OA) is one of the most prevalent chronic musculoskeletal diseases among the elderly population. In this study, macrophage-derived exosomes were isolated and identified.
Yufan Qian +6 more
doaj +2 more sources
Neuronal guidance factor Sema3A inhibits neurite ingrowth and prevents chondrocyte hypertrophy in the degeneration of knee cartilage in mice, monkeys and humans [PDF]
Bone ResearchOsteoarthritis (OA) is a degenerative joint disease accompanied with the loss of cartilage and consequent nociceptive symptoms. Normal articular cartilage maintains at aneural state.
Shishu Huang +21 more
doaj +2 more sources
The vacuolar H+ ATPase V0 subunit d2 is associated with chondrocyte hypertrophy and supports chondrocyte differentiation [PDF]
Bone Reports, 2017 Chondrocyte hypertrophy makes important contributions to bone development and growth. We have investigated a number of novel cartilage genes identified in a recent transcriptomic study to determine whether they are differentially expressed between ...
Babatunde A. Ayodele +3 more
doaj +4 more sources
PTHrP targets HDAC4 and HDAC5 to repress chondrocyte hypertrophy. [PDF]
JCI Insight, 2019 During endochondral bone formation, chondrocyte hypertrophy represents a crucial turning point from chondrocyte differentiation to bone formation. Both parathyroid hormone-related protein (PTHrP) and histone deacetylase 4 (HDAC4) inhibit chondrocyte hypertrophy. Using multiple mouse genetics models, we demonstrate in vivo that HDAC4 is required for the
Nishimori S +7 more
europepmc +3 more sources
Chondrocyte hypertrophy in skeletal development, growth, and disease
Birth Defects Research Part C: Embryo Today: Reviews, 2014 Most of our bones form through the process of endochondral ossification, which is tightly regulated by the activity of the cartilage growth plate. Chondrocyte maturation through the various stages of growth plate physiology ultimately results in hypertrophy.
Sun, Margaret Man Ger, Beier, Frank
openaire +6 more sources
Lipid phosphatase SHIP-1 regulates chondrocyte hypertrophy and skeletal development. [PDF]
J Cell Physiol, 2020 AbstractSH2‐containing inositol‐5′‐phosphatase‐1 (SHIP‐1) controls the phosphatidylinositol‐3′‐kinase (PI3K) initiated signaling pathway by limiting cell membrane recruitment and activation of Akt. Despite the fact that many of the growth factors important to cartilage development and functions are able to activate the PI3K signal transduction pathway,
So EY +9 more
europepmc +3 more sources
Indian hedgehog signals independently of PTHrP to promote chondrocyte hypertrophy [PDF]
Development, 2008 Chondrocyte hypertrophy is an essential process required for endochondral bone formation. Proper regulation of chondrocyte hypertrophy is also required in postnatal cartilage homeostasis. Indian hedgehog (Ihh) and PTHrP signaling play crucial roles in regulating the onset of chondrocyte hypertrophy by forming a negative feedback loop, in which Ihh ...
Kinglun Kingston, Mak +4 more
openaire +4 more sources
The Role of Chondrocyte Hypertrophy and Senescence in Osteoarthritis Initiation and Progression. [PDF]
Int J Mol Sci, 2020 Rim YA, Nam Y, Ju JH.
europepmc +2 more sources
In Vitro Study of Licorice on IL-1β-Induced Chondrocytes and In Silico Approach for Osteoarthritis
Pharmaceuticals, 2021 Osteoarthritis (OA) is a common degenerative joint disorder that affects joint function, mobility, and pain. The release of proinflammatory cytokines stimulates matrix metalloproteinases (MMPs) and aggrecanase production which further induces articular ...
Akhtar Ali +12 more
doaj +1 more source