Results 31 to 40 of about 11,550 (158)
Dlx5 Is a cell autonomous regulator of chondrocyte hypertrophy in mice and functionally substitutes for Dlx6 during endochondral ossification. [PDF]
PLoS ONE, 2009 The axial and appendicular skeleton of vertebrates develops by endochondral ossification, in which skeletogenic tissue is initially cartilaginous and the differentiation of chondrocytes via the hypertrophic pathway precedes the differentiation of ...
Hui Zhu, Andrew J Bendall
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Tackling chondrocyte hypertrophy with multifunctional nanoparticles [PDF]
Gene Therapy, 2016 Osteoarthritis (OA) is the most common form of arthritis and leads to irreversible changes in all articular tissues and associated skeletal muscle.1, 2 OA is a collection of different phenotypic sub-types involving different relative contributions of the stressors and pathogenic pathways that trigger and drive, respectively, disease development (Figure
BOTTINI, MASSIMO +3 more
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A critical bioenergetic switch is regulated by IGF2 during murine cartilage development
Communications Biology, 2022 Murine chondrocyte hypertrophy was found to require IGF2-regulated bioenergetic reprogramming, in which glucose utilization shifts from glycolysis to oxidative phosphorylation as chondrocytes mature.
Judith M. Hollander +8 more
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Induction and prevention of chondrocyte hypertrophy in culture. [PDF]
The Journal of cell biology, 1989 Primary chondrocytes from whole chick embryo sterna can be maintained in suspension culture stabilized with agarose for extended periods of time. In the absence of FBS, the cells remain viable only when seeded at high densities. They do not proliferate at a high rate but they deposit extracellular matrix with fibrils resembling those of authentic ...
Bruckner P +6 more
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PTHrP targets HDAC4 and HDAC5 to repress chondrocyte hypertrophy. [PDF]
JCI Insight, 2019 During endochondral bone formation, chondrocyte hypertrophy represents a crucial turning point from chondrocyte differentiation to bone formation. Both parathyroid hormone-related protein (PTHrP) and histone deacetylase 4 (HDAC4) inhibit chondrocyte hypertrophy.
Nishimori S +7 more
europepmc +3 more sources
The inhibitory effect of salmon calcitonin on tri-iodothyronine induction of early hypertrophy in articular cartilage. [PDF]
PLoS ONE, 2012 Salmon calcitonin has chondroprotective effect both in vitro and in vivo, and is therefore being tested as a candidate drug for cartilage degenerative diseases.
Pingping Chen-An +5 more
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Molecular mechanisms of long bone growth and chondrocyte regulation: A narrative review [PDF]
Precision and Future Medicine, 2023 Long bone growth is a fundamental determinant of final height. Growth, metabolism, and differentiation of chondrocytes, which are the key cellular players in this process, are regulated by systemic hormones, local factors, and cellular signaling pathways.
Eungu Kang
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Chondrocyte hypertrophy in skeletal development, growth, and disease
Birth Defects Research Part C: Embryo Today: Reviews, 2014 Most of our bones form through the process of endochondral ossification, which is tightly regulated by the activity of the cartilage growth plate. Chondrocyte maturation through the various stages of growth plate physiology ultimately results in hypertrophy.
Sun, Margaret Man Ger, Beier, Frank
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Matrix Biology Plus, 2021 The RUNX2 transcription factor is a key regulator for the development of cartilage and bone. Global or resting chondrocyte-specific deletion of the Runx2 gene results in failure of chondrocyte hypertrophy, endochondral ossification, and perinatal ...
Harunur Rashid, Haiyan Chen, Amjad Javed
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Materials Today Bio, 2023 Endochondral ossification (ECO) plays an integral part in bone augmentation, which undergoes sequential processes including mesenchymal stem cells (MSC) condensation, chondrocyte differentiation, chondrocyte hypertrophy, and mineralized bone formation ...
Shuyi Tan +7 more
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