Tackling chondrocyte hypertrophy with multifunctional nanoparticles [PDF]
Gene Therapy, 2016 Osteoarthritis (OA) is the most common form of arthritis and leads to irreversible changes in all articular tissues and associated skeletal muscle.1, 2 OA is a collection of different phenotypic sub-types involving different relative contributions of the stressors and pathogenic pathways that trigger and drive, respectively, disease development (Figure
BOTTINI, MASSIMO +3 more
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Biomechanical signals and the C-type natriuretic peptide counteract catabolic activities induced by IL-1? in chondrocyte/agarose constructs [PDF]
, 2011 Introduction: The present study examined the effect of C-type natriuretic peptide (CNP) on the anabolic and catabolic activities in chondrocyte/agarose constructs subjected to dynamic compression.
Achan, P. +19 more
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PTHrP targets HDAC4 and HDAC5 to repress chondrocyte hypertrophy. [PDF]
JCI Insight, 2019 During endochondral bone formation, chondrocyte hypertrophy represents a crucial turning point from chondrocyte differentiation to bone formation. Both parathyroid hormone-related protein (PTHrP) and histone deacetylase 4 (HDAC4) inhibit chondrocyte hypertrophy.
Nishimori S +7 more
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The inhibitory effect of salmon calcitonin on tri-iodothyronine induction of early hypertrophy in articular cartilage. [PDF]
PLoS ONE, 2012 Salmon calcitonin has chondroprotective effect both in vitro and in vivo, and is therefore being tested as a candidate drug for cartilage degenerative diseases.
Pingping Chen-An +5 more
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Molecular mechanisms of long bone growth and chondrocyte regulation: A narrative review [PDF]
Precision and Future Medicine, 2023 Long bone growth is a fundamental determinant of final height. Growth, metabolism, and differentiation of chondrocytes, which are the key cellular players in this process, are regulated by systemic hormones, local factors, and cellular signaling pathways.
Eungu Kang
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Primary cilia disassembly down regulates mechanosensitive hedgehog signalling: a feedback mechanism controlling ADAMTS-5 expression in chondrocytes [PDF]
, 2014 SummaryObjectiveHedgehog signalling is mediated by the primary cilium and promotes cartilage degeneration in osteoarthritis. Primary cilia are influenced by pathological stimuli and cilia length and prevalence are increased in osteoarthritic cartilage ...
Knight, M.M. +5 more
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Matrix Biology Plus, 2021 The RUNX2 transcription factor is a key regulator for the development of cartilage and bone. Global or resting chondrocyte-specific deletion of the Runx2 gene results in failure of chondrocyte hypertrophy, endochondral ossification, and perinatal ...
Harunur Rashid, Haiyan Chen, Amjad Javed
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Materials Today Bio, 2023 Endochondral ossification (ECO) plays an integral part in bone augmentation, which undergoes sequential processes including mesenchymal stem cells (MSC) condensation, chondrocyte differentiation, chondrocyte hypertrophy, and mineralized bone formation ...
Shuyi Tan +7 more
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Influence of BMP-2 on chondrocyte hypertrophy.
, 2015 Chondrocyte hypertrophy is expressed as a fold increase relative to chondrocyte hypertrophy without BMP-2.
María José Gómez-Benito (544706) +4 more
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Extracellular Matrix Domain Formation as an Indicator of Chondrocyte Dedifferentiation and Hypertrophy [PDF]
Tissue Engineering Part C: Methods, 2013 Cartilage injury represents one of the most significant clinical conditions. Implantation of expanded autologous chondrocytes from noninjured compartments of the joint is a typical strategy for repairing cartilage. However, two-dimensional culture causes dedifferentiation of chondrocytes, making them functionally inferior for ...
Wu, Ling +10 more
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