The inhibitory effect of salmon calcitonin on tri-iodothyronine induction of early hypertrophy in articular cartilage. [PDF]
PLoS ONE, 2012 Salmon calcitonin has chondroprotective effect both in vitro and in vivo, and is therefore being tested as a candidate drug for cartilage degenerative diseases.
Pingping Chen-An +5 more
doaj +1 more source
Chondrocyte hypertrophy in skeletal development, growth, and disease
Birth Defects Research Part C: Embryo Today: Reviews, 2014 Most of our bones form through the process of endochondral ossification, which is tightly regulated by the activity of the cartilage growth plate. Chondrocyte maturation through the various stages of growth plate physiology ultimately results in hypertrophy.
Sun, Margaret Man Ger, Beier, Frank
openaire +4 more sources
Pharmacological treatments for osteoarthritis: Emerging therapeutic strategies targeting chondrocyte hypertrophy and inflammation [PDF]
, 2022 In this thesis I aimed to identify pharmacological targets for osteoarthritis, targeting chondrocyte hypertrophy and ...
Ferrao Blanco, Mauricio
core +2 more sources
Primary cilia disassembly down regulates mechanosensitive hedgehog signalling: a feedback mechanism controlling ADAMTS-5 expression in chondrocytes [PDF]
, 2014 SummaryObjectiveHedgehog signalling is mediated by the primary cilium and promotes cartilage degeneration in osteoarthritis. Primary cilia are influenced by pathological stimuli and cilia length and prevalence are increased in osteoarthritic cartilage ...
Knight, M.M. +5 more
core +1 more source
Materials Today Bio, 2023 Endochondral ossification (ECO) plays an integral part in bone augmentation, which undergoes sequential processes including mesenchymal stem cells (MSC) condensation, chondrocyte differentiation, chondrocyte hypertrophy, and mineralized bone formation ...
Shuyi Tan +7 more
doaj +1 more source
Matrix Biology Plus, 2021 The RUNX2 transcription factor is a key regulator for the development of cartilage and bone. Global or resting chondrocyte-specific deletion of the Runx2 gene results in failure of chondrocyte hypertrophy, endochondral ossification, and perinatal ...
Harunur Rashid, Haiyan Chen, Amjad Javed
doaj +1 more source
Expression patterns of chondrocyte genes cloned by differential display in tibial dyschondroplasia
, 2000 Tibial dyschondroplasia (TD) appears to involve a failure of the growth plate chondrocytes within growing long bones to differentiate fully to the hypertrophic stage, resulting in a mass of prehypertrophic chondrocytes which form the avascular TD lesion.
Farquharson, C +9 more
core +1 more source
Influence of BMP-2 on chondrocyte hypertrophy.
, 2015 Chondrocyte hypertrophy is expressed as a fold increase relative to chondrocyte hypertrophy without BMP-2.
María José Gómez-Benito (544706) +4 more
core +1 more source
Extracellular Matrix Domain Formation as an Indicator of Chondrocyte Dedifferentiation and Hypertrophy [PDF]
Tissue Engineering Part C: Methods, 2013 Cartilage injury represents one of the most significant clinical conditions. Implantation of expanded autologous chondrocytes from noninjured compartments of the joint is a typical strategy for repairing cartilage. However, two-dimensional culture causes dedifferentiation of chondrocytes, making them functionally inferior for ...
Wu, Ling +10 more
openaire +3 more sources
Recapitulating Endochondral Ossification for Bone Repair: From Development to Engineering Strategy
Advanced Healthcare Materials, EarlyView.This review summarizes the developmental basis of endochondral ossification (ECO) and its applications in bone tissue engineering (BTE). It first outlines the key biological processes and signaling pathways underlying ECO, then discusses biomaterial‐based engineering strategies derived from these principles, and finally highlights future directions for
Yiqi Su +8 more
wiley +1 more source