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Hedgehog Signaling in Endochondral Ossification [PDF]

Journal of Developmental Biology, 2016
Hedgehog (Hh) signaling plays crucial roles in the patterning and morphogenesis of various organs within the bodies of vertebrates and insects. Endochondral ossification is one of the notable developmental events in which Hh signaling acts as a master ...
Shinsuke Ohba
exaly   +6 more sources

The investigation of bone fracture healing under intramembranous and endochondral ossification [PDF]

Bone Reports, 2021
After trauma, fractured bone starts healing directly through bone union or indirectly through callus formation process. Intramembranous and endochondral ossification are two commonly known mechanisms of indirect healing.
Saeed Miramini, Li-Hai Zhang, Smriti Ghimire   +2 more
exaly   +4 more sources

Endochondral ossification of the mouse nasal septum [PDF]

The Anatomical Record Part A: Discoveries in Molecular, Cellular, and Evolutionary Biology, 2006
AbstractEndochondral ossification at the caudal junctions of the cartilaginous nasal septum, in combination with interstitial expansion of the septum, is thought to displace the facial skeleton away from the neurocranium. However, the rate of endochondral ossification has not been measured or related to rates of septal enlargement.
Susan W Herring
exaly   +3 more sources

Regeneration of Humeral Head Using a 3D Bioprinted Anisotropic Scaffold with Dual Modulation of Endochondral Ossification [PDF]

Advanced Science, 2023
Tissue engineering is theoretically thought to be a promising method for the reconstruction of biological joints, and thus, offers a potential treatment alternative for advanced osteoarthritis.
Tao Li, Zhengjiang Ma, Yuxin Zhang, Zezheng Yang, Wentao Li, Dezhi Lu, Yihao Liu, Lei Qiang, Tianchang Wang, Ya Ren, Wenhao Wang, Hongtao He, Xiaojun Zhou, Yuanqing Mao, Junfeng Zhu, Jinwu Wang, Xiaodong Chen, Kerong Dai   +17 more
doaj   +2 more sources

Ubiquitin-specific protease 26 facilitates endochondral ossification by driving chondrocyte hypertrophy and mineralization [PDF]

Bone Research
Chondrocyte hypertrophy and mineralization are essential for endochondral ossification; however, the mechanisms underlying these processes remain incompletely understood.
Changwei Li, Yiming Xu, Li Zhou, Leilei Chang, Zhou Dan, Yunhe Jiang, Chao Wang, Lianfu Deng, Guoqing Tang   +8 more
doaj   +2 more sources

Knockdown of LncRNA H19 inhibits vascularization and endochondral ossification via the MiRNA-21a-5p-Smad7/p-Smad2/3 pathway in fracture repair [PDF]

Scientific Reports
The biological process of fracture repair involves inflammation, vascularization, endochondral ossification, and cartilage production. Long non-coding RNAs (lncRNAs) are essential for the growth and maintenance of the skeleton. In this study, the role of
Qiuyue Sun, Chen Zhang, Bowen Chen, Junyi Liao, Aowen Bao, Chen Zhao, Hong Chen, Dawei He, Wei Huang, Guangming Dai   +9 more
doaj   +2 more sources

Notch1 signaling regulates Sox9 and VEGFA expression and governs BMP2-induced endochondral ossification of mesenchymal stem cells [PDF]

Genes and Diseases
Although bone morphogenetic protein 2 (BMP2) can induce chondrogenic differentiation of mesenchymal stem cells (MSCs), its induction of endochondral ossification limits the application of BMP2-based cartilage regeneration.
Jing Zou, Chengcheng Du, Senrui Liu, Piao Zhao, Shengqiang Gao, Bowen Chen, Xiangdong Wu, Wei Huang, Zhenglin Zhu, Junyi Liao   +9 more
doaj   +2 more sources

SMN deficiency inhibits endochondral ossification via promoting TRAF6-induced ubiquitination degradation of YBX1 in spinal muscular atrophy [PDF]

Bone Research
Survival of motor neuron (SMN) protein encoded by SMN1 gene, is the essential and ubiquitously expressed protein in all tissues. Prior studies demonstrated that SMN deficiency impaired bone development, but the underlying mechanism of abnormal ...
Zijie Zhou, Xinbin Fan, Taiyang Xiang, Yinxuan Suo, Xiaoyan Shi, Yaoyao Li, Yimin Hua, Lei Sheng, Xiaozhong Zhou   +8 more
doaj   +2 more sources

A multi-model approach identifies ALW-II-41-27 as a promising therapy for osteoarthritis-associated inflammation and endochondral ossification [PDF]

Heliyon
Low-grade inflammation and pathological endochondral ossification are key processes underlying the progression of osteoarthritis, the most prevalent joint disease worldwide.
Mauricio N. Ferrao Blanco, Raphaelle Lesage, Nicole Kops, Niamh Fahy, Fjodor T. Bekedam, Athina Chavli, Yvonne M. Bastiaansen-Jenniskens, Liesbet Geris, Mark G. Chambers, Andrew A. Pitsillides, Roberto Narcisi, Gerjo J.V.M. van Osch   +11 more
doaj   +2 more sources

Modeling vascular dynamics at the initial stage of endochondral ossification on a microfluidic chip using a human embryonic-stem-cell-derived organoid [PDF]

Regenerative Therapy
Vascular interactions play a crucial role in embryogenesis, including skeletal development. During endochondral ossification, vascular networks are formed as mesenchymal cells condense and later invade skeletal elements to form the bone marrow.
Abhiraj Kesharwani, Shoichiro Tani, Masaki Nishikawa, Yasuyuki Sakai, Hiroyuki Okada, Shinsuke Ohba, Ung-il Chung, Hironori Hojo   +7 more
doaj   +2 more sources