Hedgehog Signaling in Endochondral Ossification [PDF]
Journal of Developmental Biology, 2016 Hedgehog (Hh) signaling plays crucial roles in the patterning and morphogenesis of various organs within the bodies of vertebrates and insects. Endochondral ossification is one of the notable developmental events in which Hh signaling acts as a master ...
Shinsuke Ohba, Ohba Shinsuke
exaly +5 more sources
The investigation of bone fracture healing under intramembranous and endochondral ossification
Bone Reports, 2021 After trauma, fractured bone starts healing directly through bone union or indirectly through callus formation process. Intramembranous and endochondral ossification are two commonly known mechanisms of indirect healing.
Smriti Ghimire +2 more
exaly +3 more sources
Regeneration of Humeral Head Using a 3D Bioprinted Anisotropic Scaffold with Dual Modulation of Endochondral Ossification [PDF]
Advanced Science, 2023 Tissue engineering is theoretically thought to be a promising method for the reconstruction of biological joints, and thus, offers a potential treatment alternative for advanced osteoarthritis.
Tao Li +17 more
doaj +2 more sources
Failures of Endochondral Ossification in the Mucopolysaccharidoses. [PDF]
Curr Osteoporos Rep, 2020 The mucopolysaccharidoses (MPS) are a group of inherited lysosomal storage disorders characterized by abnormal accumulation of glycosaminoglycans (GAGs) in cells and tissues. MPS patients frequently exhibit failures of endochondral ossification during postnatal growth leading to skeletal deformity and short stature.
Jiang Z, Byers S, Casal ML, Smith LJ.
europepmc +4 more sources
Endochondral ossification of the mouse nasal septum [PDF]
The Anatomical Record Part A: Discoveries in Molecular, Cellular, and Evolutionary Biology, 2006 AbstractEndochondral ossification at the caudal junctions of the cartilaginous nasal septum, in combination with interstitial expansion of the septum, is thought to displace the facial skeleton away from the neurocranium. However, the rate of endochondral ossification has not been measured or related to rates of septal enlargement.
Susan W Herring
exaly +3 more sources
Zfhx4 regulates endochondral ossification as the transcriptional platform of Osterix in mice [PDF]
Communications Biology, 2021 Nakamura et al. used expression studies to identify an enrichment of Zfhx4 in cartilage and revealed through global gene knock-down that it is required for proper endochondral ossification in mice.
Eriko Nakamura +16 more
doaj +2 more sources
Ubiquitin-specific protease 26 facilitates endochondral ossification by driving chondrocyte hypertrophy and mineralization [PDF]
Bone ResearchChondrocyte hypertrophy and mineralization are essential for endochondral ossification; however, the mechanisms underlying these processes remain incompletely understood.
Changwei Li +8 more
doaj +2 more sources
Advanced Science, 2021 Biomaterials play an important role in treating bone defects by promoting direct osteogenic healing through intramembranous ossification (IO). However, majority of the body's bones form via cartilaginous intermediates by endochondral ossification (EO), a
Zhaogang Yang, Wen Jiang, Yuan Yuan
exaly +2 more sources
Knockdown of LncRNA H19 inhibits vascularization and endochondral ossification via the MiRNA-21a-5p-Smad7/p-Smad2/3 pathway in fracture repair [PDF]
Scientific ReportsThe biological process of fracture repair involves inflammation, vascularization, endochondral ossification, and cartilage production. Long non-coding RNAs (lncRNAs) are essential for the growth and maintenance of the skeleton. In this study, the role of
Qiuyue Sun +9 more
doaj +2 more sources
Notch1 signaling regulates Sox9 and VEGFA expression and governs BMP2-induced endochondral ossification of mesenchymal stem cells [PDF]
Genes and DiseasesAlthough bone morphogenetic protein 2 (BMP2) can induce chondrogenic differentiation of mesenchymal stem cells (MSCs), its induction of endochondral ossification limits the application of BMP2-based cartilage regeneration.
Jing Zou +9 more
doaj +2 more sources